342 results match your criteria: "Bowenoid Papulosis"
Article Synopsis
- The article presents a clinical case of a young patient with HPV-associated penile intraepithelial neoplasia (PIN), specifically the erythematous form of bowenoid papulosis.
- It highlights the issues of delayed diagnosis due to improper diagnostic approaches and a lack of awareness among doctors about cancer-related diseases.
- The piece emphasizes the significance of early detection in preventing progression to more severe conditions like squamous cell penile carcinoma, detailing the different subtypes of PIN and their varying risks of leading to cancer.
The combination of holmium laser and ALA-PDT for Bowenoid Papulosis with diffuse large B-cell lymphoma.
Photodiagnosis Photodyn Ther
February 2024
Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China. Electronic address:
Article Synopsis
- Bowenoid Papulosis (BP) is a pre-cancerous condition that affects the anogenital area and can become serious if combined with immunosuppression, leading to potential complications like squamous cell carcinoma.
- A complex case involving BP, Bowen's disease, and Diffuse Large B-Cell Lymphoma was treated successfully using a combination of holmium laser therapy and 5-Aminolevulinic Acid Photodynamic Therapy (ALA-PDT).
- After treatment, the lesion completely disappeared and there was no recurrence of the affected area for five years.
Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen's disease: a retrospective study.
Front Med (Lausanne)
November 2023
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Article Synopsis
- Bowen's disease (BD) is a precancerous skin condition that often gets misdiagnosed due to similarity with other skin diseases, with a study showing a diagnosis accuracy of just 54%.
- A retrospective study of 50 patients revealed that the average onset age was 55.1 for males and 58.2 for females, with the disease duration averaging 25.3 months for males and 33.9 months for females, but there were no significant differences based on gender.
- The study also found that 66% of BD patients had other health conditions, with skin diseases being the most common comorbidity, while the majority of cases showed signs of squamous-cell hyperplasia and other atypical cellular characteristics
Dermoscopy of condyloma lata: An observational controlled study.
Australas J Dermatol
November 2023
Private practice, Vicenza, Trento, Italy.
Transcriptional analysis reveals distinct gene expression profiles of three bowenoid papulosis patients.
Exp Dermatol
September 2023
Department of Dermatology and Venereology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China.
Article Synopsis
- - Bowenoid papulosis (BP) is a mild but potentially cancerous condition related to HPV, with recent studies highlighting its significance, though how it develops is still unclear.
- - In our research with three HPV-positive BP patients, skin biopsies showed common histological changes like dyskeratosis and atypical keratinocytes, alongside RNA sequencing identifying 486 genes that were differently expressed compared to controls.
- - Our findings suggest that pathways involved in inflammation, metabolism, and cell proliferation are crucial in BP, potentially offering new targets for treatment through the inhibition of these signaling pathways.
Correlations between Histopathological and Confocal Reflectance Microscopy Aspects in a Patient with Bowenoid Papulosis.
Diagnostics (Basel)
April 2023
Department of Dermatology and Allergology, Elias University Emergency Hospital, 011461 Bucharest, Romania.
Article Synopsis
- - Bowenoid papulosis is a skin condition linked to HPV infections, which can potentially develop into squamous cell carcinoma, making its diagnosis and treatment important.
- - A 34-year-old non-smoker presented with asymptomatic, pigmented lesions on the penis, leading to a diagnosis confirmed by reflectance confocal microscopy and histopathological exam.
- - Treatment involved Imiquimod and Isoprinosine, resulting in positive progress after 6 weeks, showcasing reflectance confocal microscopy as an effective, non-invasive way to diagnose and monitor treatment response.
Uncommon Location of Bowenoid Papulosis.
Indian J Dermatol
January 2022
Unit of Dermatology, Hospital de Barbastro, Barbastro, Huesca, Spain E-mail:
Clinical features of bowenoid papulosis of prepuce associated with diabetes mellitus.
Photodiagnosis Photodyn Ther
June 2023
Department of Dermatology, Huadong Hospital, Fudan University, Shanghai, China. Electronic address:
Article Synopsis
- Hailey-Hailey disease can appear in the anal area, which is not common for this condition.
- It typically shows up as lichenoid lesions, often accompanied by crusty erosions around the anus.
- It's important to differentiate it from similar conditions like condylomata acuminata, extramammary Paget disease, and bowenoid papulosis.
A Clinico-Demographic Profile and Sexual Behaviour Pattern in Attendees of Designated STI/RTI Clinic Having Sexually Transmitted Infections with Special Reference to HIV Seropositivity.
Indian J Dermatol
January 2022
Department of Dermatology, Bankura Sammilani Medical College (BSMCH), Gobindanagar, Bankura, West Bengal, India.
Article Synopsis
- The study investigates the prevalence of sexually transmitted infections (STIs) among patients at a designated STI/RTI clinic and examines the relationship between sexual behavior, demographic factors, and HIV status.
- Findings revealed that common STIs included herpes genitalis (42.86%) and condyloma acuminata (26.37%), while a significant portion of participants reported inconsistent condom use (only 16.4% used them correctly).
- The research highlights diverse sexual orientations among participants, with heterosexuals making up the majority (64.83%), and indicates a concerning rate of reactive HIV tests (8.8% RPR and 12.1% ICTC reactive).
Vulvar Verruciform Xanthoma: A Comprehensive Literature Review.
Clin Cosmet Investig Dermatol
August 2022
First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, People's Republic of China.
Article Synopsis
- Verruciform xanthoma (VX) is a rare, non-cancerous skin growth that appears as a warty-looking lesion, most commonly found on the vulva, especially the labia minora and clitoris.* -
- The lesions can be mistakenly diagnosed as other skin issues like warts or cancers, and factors like chronic inflammation, trauma, and scratching may contribute to their development.* -
- Treatment typically involves surgically removing the lesions for complete resolution.*
A Rare Presentation of Extragenital Bowenoid Papulosis.
Cureus
May 2022
Dermatology, Mayo Clinic, Rochester, USA.
Article Synopsis
- * Diagnosis involves clinical examination and skin biopsy, and HPV can be identified using chromogen in situ hybridization.
- * A unique case is presented where an immunocompromised patient had bowenoid papulosis with plaque lesions on the face, confirmed to be associated with high-risk HPV types.
Effectiveness of photodynamic therapy with 5-aminolevulinic acid for Bowenoid papulosis: A retrospective study with long-term follow-up.
Photodiagnosis Photodyn Ther
September 2022
Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:
Article Synopsis
- Bowenoid papulosis (BP) is a rare skin disease linked to HPV types 16 and 18, primarily targeting sexually active young individuals and has the potential to progress to cancer.
- A study evaluated the effectiveness of photodynamic therapy using 5-aminolevulinic acid (ALA-PDT) against traditional treatments, focusing on lesion clearance and recurrence rates.
- Results indicated that ALA-PDT outperformed conventional methods in clearing lesions, reducing recurrence rates, and achieving higher patient satisfaction.
Human papillomavirus genotype distribution of genital keratotic lesions.
Australas J Dermatol
August 2022
Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
Article Synopsis
- The study investigates three types of genital keratotic lesions: bowenoid papulosis (BP), which is linked to high-risk HPV; condyloma acuminatum (CA), associated with low-risk HPV; and genital seborrheic keratosis (GSK), a benign tumor without a clear HPV connection.
- Findings show that both BP and GSK are related to high-risk HPV, while CA is tied to low-risk HPV, suggesting that GSK may be a distinct tumor rather than just an aging form of CA.
- The presence of high-risk HPV in GSK raises concerns for physicians, emphasizing the need for more proactive treatment and ongoing monitoring of these patients.
Condylomata acuminata, Bowenoid papulosis, and squamous cell carcinoma, all positive for human papillomavirus type 16/18 DNA, coexisting in the genital area: a case report.
Acta Dermatovenerol Alp Pannonica Adriat
September 2021
Department of Dermatology, School of Medicine, University of Patras, Patras, Greece.
Article Synopsis
- A case is presented involving a male patient with multiple genital issues, including condylomata acuminata, Bowenoid papulosis, and squamous cell carcinoma.
- All these conditions are linked to HPV types 16 and 18, which are known to increase the risk of penile cancer.
- The report aims to highlight the importance of early diagnosis and treatment for these conditions among healthcare providers.
Secondary Localized Cutaneous Amyloidosis is not Rare in Bowen's Disease and Bowenoid Papulosis.
Turk Patoloji Derg
March 2022
Department of Dermatology &Venereology, Istanbul University, Istanbul Faculty of Medicine, ISTANBUL, TURKEY.
Article Synopsis
- Secondary localized cutaneous amyloidosis is a skin condition found in various skin diseases, including benign and malignant types, but it's not clinically significant.
- A study analyzed cases of Bowen's disease and Bowenoid papulosis from 2006 to 2017 and found that 5.8% of Bowen's cases and 16.7% of Bowenoid papulosis cases exhibited this amyloidosis.
- The research highlights a notable link between these skin conditions and amyloidosis, particularly for Bowenoid papulosis, suggesting that treatments causing cell death may play a role in its development.
Dermoscopic findings of genital keratotic lesions: Bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum.
Photodiagnosis Photodyn Ther
December 2021
Department of Dermatology, Kosin University College of Medicine, Busan, South Korea. Electronic address:
Article Synopsis
- Dermatologists face challenges in diagnosing keratotic or warty lesions in the genital area due to overlapping features of conditions like bowenoid papulosis, seborrheic keratosis, and condyloma acuminatum.
- The study compared dermoscopic features of these lesions, finding that bowenoid papulosis showed predominant glomerular vessels and mucosal pigmentation, while seborrheic keratosis was less vascular and had a cerebriform appearance.
- Condyloma acuminatum was identified by its finger-like shape and highly vascular features, with distinct findings that can aid in non-invasive differentiation of these lesions.
Two Cases of Multiple Epidermolytic Acanthomas Mimicking Verruca Vulgaris.
Ann Dermatol
December 2020
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Article Synopsis
- - Epidermolytic acanthoma (EA) is a rare, benign tumor that typically appears as a small, solitary skin papule, but can also occur in multiple forms, often in the genital area.
- - Case reports highlight two male patients with multiple skin-colored papules around the genital area that resembled other conditions, leading to potential misdiagnosis.
- - Skin biopsies of both patients confirmed the presence of EA, characterized by specific microscopic features, and both tested negative for human papillomavirus, emphasizing the need for proper diagnosis of similar skin lesions.
A case of perianal bowenoid papulosis: dermoscopic features and a review of previous cases.
Acta Dermatovenerol Alp Pannonica Adriat
March 2021
Department of Dermatology and Venereology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Article Synopsis
- Bowenoid papulosis is a rare precancerous skin condition linked to oncogenic types of human papillomavirus (HPV) and typically affects young, sexually active individuals.
- The condition shares similar microscopic characteristics with Bowen's disease, complicating diagnosis.
- The case report emphasizes the importance of dermoscopy in diagnosing bowenoid papulosis and seeks to enhance its application in clinical settings, despite the lack of established diagnostic criteria for this condition.
Genital premalignant and malignant diseases: a retrospective study of male genital skin biopsies.
Int J Dermatol
June 2021
Mater Misericordiae Hospital, Brisbane, Queensland, Australia.
Article Synopsis
- Genital skin malignancies are rare but can lead to serious health issues, emphasizing the need for better clinician knowledge to prevent delays in diagnosis and treatment.
- A study analyzed 1525 male genital skin biopsies from 2017-2018, revealing that 5% were premalignant or malignant, with the most common types being penile intraepithelial neoplasia and invasive squamous cell carcinoma.
- Understanding the prevalence and types of these conditions can improve education and research, ultimately aiding in earlier detection and intervention.
The prevalence of human leucocyte antigen and human papillomavirus DNA in penile intraepithelial neoplasia in England 2011-2012.
Int J STD AIDS
April 2021
Dermatology Department, University College Hospital, Chelsea and Westminster Hospital, London, UK.
Article Synopsis
- The study investigates the role of HPV infection and human leukocyte antigen (HLA) polymorphisms in the development of penile intraepithelial neoplasia (PeIN).
- Out of 72 cases analyzed, HPV DNA was found in 90.2% of PeIN samples, with HPV16 being the most common type, indicating a strong association between HPV and PeIN.
- Specific HLA genotypes, such as HLA-C*15 increasing risk and HLA-DQA1*01 offering protection, suggest that immune genetics may also contribute to PeIN's development.
[Update on precursors of vulvar carcinoma].
Gynecol Obstet Fertil Senol
June 2021
Institut Curie Saint-Cloud, 35, rue Dailly, 92210 Saint-Cloud, France; Université de Versailles-Saint-Quentin-en-Yvelines, UFR sciences de la santé, Versailles, France. Electronic address:
Article Synopsis
- * Histopathological techniques struggle to differentiate between these lesions, but P16 and P53 immunostaining can help identify HPV infection and classify dVIN types, although P53 has limited effectiveness in detecting dVIN.
- * First-line treatments focus on medical management, with topical corticosteroids for dVIN and imiquimod for HSIL; HPV vaccination and early
Dihydroartemisinin administration improves the effectiveness of 5-aminolevulinic acid-mediated photodynamic therapy for the treatment of high-risk human papillomavirus infection.
Photodiagnosis Photodyn Ther
March 2021
Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou 510091, China.
Article Synopsis
- High-risk human papillomavirus (HR-HPV) infection is linked to serious diseases like cervical cancer, and this study investigates the combined use of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) with dihydroartemisinin (DHA) to treat these infections.
- * The research used the HeLa cervical cancer cell line to analyze the effects of ALA-PDT and DHA on cell behavior, including viability, proliferation, and apoptosis, while examining specific protein pathways involved.
- * Findings indicate that DHA enhances ALA-PDT's effectiveness by inhibiting the NF-κB-HIF-1α-VEGF pathway and activating a protective pathway, suggesting that combining these treatments could