5,888 results match your criteria: "Bowen Disease"

Photodynamic therapy in dermatology: established and new indications.

J Dtsch Dermatol Ges

December 2024

Center for Dermatology, Allergology and Dermatosurgery, Helios University Hospital Wuppertal, University of Witten/Herdecke, Wuppertal, Germany.

Photodynamic therapy (PDT) is internationally established as an approved treatment option for in situ forms of keratinocytic skin cancer (actinic keratoses, Bowen's disease, basal cell carcinoma). For these indications, there are standardized treatment protocols using narrow-spectrum light sources or (artificial) daylight, the use of which is associated with successful healing, a low rate of lesion recurrence, and a very good cosmetic result. Daylight PDT is superior to conventional PDT in terms of significantly less pain and associated higher patient acceptance.

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Clinicopathologic Features of Eyelid Sebaceous Gland Carcinoma Requiring Immunohistochemical Diagnosis.

Ocul Oncol Pathol

September 2024

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

Article Synopsis
  • The study evaluated eyelid sebaceous gland carcinoma (SGC) by analyzing 27 patients diagnosed at Toyama University Hospital from 2016 to 2022, emphasizing the importance of immunohistochemistry for accurate diagnosis.!
  • Five patients misdiagnosed initially with other cancers (including squamous cell carcinoma) were correctly identified as having SGC through additional immunostaining for adipophilin and androgen receptor.!
  • The research highlights that SGC may be misdiagnosed as other malignancies, and that immunostaining is essential for a definitive diagnosis, particularly in cases of less differentiated cancers like SCC.!
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Article Synopsis
  • Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular issues, and the ETHOS trial showed that triple therapy with budesonide/glycopyrrolate/formoterol fumarate (BGF) lowered the rates of exacerbations and all-cause mortality compared to dual therapies.
  • The study aimed to evaluate the effects of BGF on cardiovascular events and the time to first severe exacerbation, finding that BGF 320 significantly reduced the occurrence of major adverse cardiac events and other serious cardiopulmonary issues when compared to dual therapy with glycopyrrolate/formoterol fumarate (GFF).
  • Overall, BGF demonstrated a notable benefit in reducing
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Hepatitis Delta Virus Surveillance Practice among Clinicians in Nigeria: A Cross-Sectional Survey.

Niger J Clin Pract

August 2024

Enlightenment Initiative on Viral Hepatitis, Ede, Osun State, Nigeria.

Background: The near total absence of routine Hepatitis Delta Virus (HDV) screening in many countries in sub-Saharan Africa is a major challenge to understanding the burden of HDV in the region.

Aim: To evaluate Hepatitis Delta Virus screening practices and associated factors among clinicians in Nigeria.

Methods: A cross-sectional study was conducted in June-July 2022, in which a self-administered questionnaire that inquired about HDV awareness, screening practices, and treatment options was shared electronically with consenting clinicians practicing in Nigeria.

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Background: Skin concerns are frequent among urban-living Aboriginal children, yet specialist dermatology consultations are limited with studies highlighting the need for improved cultural security. Through newly established paediatric dermatology clinics at two urban Aboriginal Community Controlled Health Organisations (ACCHOs), we aimed to describe clinic and patient data, including disease frequencies and associations, to inform dermatology service provision and advocacy.

Methods: A prospective cohort study of Aboriginal children and young people (CYP, 0-18 years) attending Aboriginal Health Practitioner (AHP) co-ordinated paediatric dermatology clinics at two urban ACCHOs.

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Article Synopsis
  • - Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, with early recognition being crucial as delayed diagnosis can lead to more aggressive forms and surgical complications.
  • - Bowen's disease (BD) is an early stage of cSCC that shows specific skin features, but histopathology is essential for accurate diagnosis and treatment planning.
  • - Diagnosing precancerous conditions like vulvar and penile intraepithelial neoplasia (VIN and PeIN) can be complex, often requiring multiple biopsies and utilizing techniques like immunostaining and HPV testing to guide treatment options.
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  • - The study analyzed trends and racial disparities in hospitalizations for diverticular disease (DD) from 2017 to 2020, using data from over 1.2 million hospitalizations to assess outcomes like mortality and resource use by race and ethnicity.
  • - Findings revealed that White patients accounted for 75.3% of DD hospitalizations, were generally younger, and that overall hospitalizations increased until 2020, when a significant decrease of 11.8% occurred.
  • - Notably, mortality rates and in-hospital complications varied by race, with significant differences in outcomes observed, highlighting ongoing disparities in healthcare for different ethnic groups.
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Arsenical keratosis in China: A case report and review of the literature.

Skin Res Technol

September 2024

Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China.

Article Synopsis
  • Arsenical keratosis is a skin condition linked to long-term arsenic exposure, primarily through non-compliant use of arsenic in traditional Chinese medicine for psoriasis treatment.
  • A review of 64 studies over 32 years revealed that 92.21% of arsenic cases were iatrogenic, with most patients displaying hyperkeratotic lesions and more than half developing skin tumors.
  • Treatment outcomes were generally positive, with a significant improvement in skin lesions for patients treated with Acitretin Capsules, although one patient succumbed to metastatic squamous cell carcinoma.
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Feral swine are invasive in the United States and a reservoir for infectious diseases. The increase in feral swine population and the geographic range are a concern for the spread of zoonotic diseases to humans and livestock. Feral swine could contribute to the spread of the causative agent of human Q fever.

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Age and Menopausal Status in Idiopathic Subglottic Stenosis.

Laryngoscope

January 2025

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.

Objective: To evaluate the impact of age on disease recurrence in idiopathic subglottic stenosis (iSGS) patients.

Methods: This was a retrospective chart review of iSGS patients treated with laser wedge excision. Patients did not have prior surgery.

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Background: Cutaneous squamous cell carcinoma in situ (Bowen's disease) is a precancerous condition confined to the epidermis of the skin. Despite the critical need for effective interventions to halt its progression, there remains a notable shortage of comprehensive data comparing the efficacy of various therapeutic approaches.

Objectives: This systematic review and meta-analysis endeavour to compare the different efficacies of interventions by investigating and synthesizing data from numerous trials.

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Methotrexate and Rituximab Use in Highly Recurrent Idiopathic Subglottic Stenosis.

Laryngoscope

January 2025

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.

Objective: To evaluate the impact of methotrexate and rituximab therapy on highly recurrent idiopathic subglottic stenosis (iSGS) patients with a negative antineutrophil cytoplasmic antibody titer cANCA(-).

Methods: This was a retrospective cohort study of highly recurrent iSGS patients who recurred within 1 year or less and were treated with methotrexate (MTX), and rituximab (RTX), or a combination of both at different time points (MTX/RTX). Average surgical durations before and after drug treatment were summarized, and the differences were calculated.

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The rapid spread of coronavirus disease 2019 (COVID-19) worldwide prompted global fear and panic among all populations. The Fear of COVID-19 Scale was developed to assess the degree of fear. This review summarizes and synthesizes the revised cross-cultural validation studies of the Revised Fear of COVID-19 Scale to explore the properties of the scale and fear characteristics among different populations.

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Background: Research suggests a bidirectional relationship between food insecurity and stress, but few studies have examined associations of food insecurity with stress and other indicators of cardiometabolic health, including depression, diet quality, and body weight, among lower-income women in the U.S.

Methods: This cross-sectional study analyzed data from lower-income women caregivers living in North Carolina (n = 100): 42% Black/African American, 25% Hispanic/Latina, and 33% White women.

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Article Synopsis
  • - Chronic wasting disease (CWD) is a fatal disease affecting deer caused by prions, which can be transmitted through various means like feces, urine, and the environment, complicating management efforts.
  • - There's a lack of easy non-invasive tests to detect CWD in live animals, but recent research focuses on using dogs to identify the smell of CWD-infected animals through their feces.
  • - Successful training of dogs to discern the odors of infected versus non-infected deer offers a promising non-invasive method for monitoring CWD in both wild and farmed cervid populations.
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Background: Japanese guidelines recommend triple inhaled corticosteroid (ICS)/long-acting muscarinic antagonist (LAMA)/long-acting β-agonist (LABA) therapy in patients with chronic obstructive pulmonary disease (COPD) and no concurrent asthma diagnosis who experience frequent exacerbations and have blood eosinophil (EOS) count ≥ 300 cells/mm, and in patients with COPD and asthma with continuing/worsening symptoms despite receiving dual ICS/LABA therapy. These post-hoc analyses of the KRONOS study in patients with COPD and without an asthma diagnosis, examine the effects of fixed-dose triple therapy with budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) versus dual therapies on lung function and exacerbations based on blood EOS count - focusing on blood EOS count 100 to < 300 cells/mm - as a function of exacerbation history and COPD severity.

Methods: In KRONOS, patients were randomized to receive treatments that included BGF 320/14.

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Article Synopsis
  • The dermoscopy of squamous cell carcinoma (SCC) helps differentiate between types based on keratin, vascular, and pigment features.
  • Non-pigmented actinic keratoses have a "strawberry pattern," while pigmented actinic keratosis shows similarities to lentigo maligna but can be distinguished by specific signs like pigmented scales and erythema.
  • Dermoscopy is crucial for early detection of invasive SCC, with its presentation varying by tumor differentiation—keratin features in well-differentiated tumors and atypical vascular patterns in poorly differentiated ones.
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Prenatal molecular diagnosis of pyruvate dehydrogenase complex deficiency enables rapid initiation of ketogenic diet.

Am J Med Genet A

December 2024

Department of Neurology, Child Neurology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Article Synopsis
  • Pyruvate dehydrogenase complex deficiency (PDCD) is a mitochondrial disorder that affects how the body processes carbohydrates and can lead to increased lactic acid and issues with the nervous system.
  • Early treatment with a ketogenic diet may help improve both metabolic and neurological outcomes for those affected.
  • This case study demonstrates the value of prenatal ultrasounds to identify brain abnormalities, leading to a molecular diagnosis of PDCD and successful early intervention with a ketogenic diet and other treatments, resulting in positive developmental progress.
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The Utility of the Koala Scat: A Scoping Review.

Biology (Basel)

July 2024

Saunders Havill Group, Bowen Hills 4006, Australia.

The use of samples or scats to provide important ecological, genetic, disease and physiology details on free-range populations is gaining popularity as an alternative non-invasive methodology. Koala populations in SE Queensland and NSW have recently been listed as endangered and continue to face anthropomorphic and stochastic environmental impacts that could potentially lead to their extinction. This scoping review examines the current and potential utility of the koala scat to contribute data relevant to the assessment of koala conservation status and decision making.

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Left ventricular strain-volume loops in bicuspid aortic valve disease: new insights in cardiomechanics.

Eur Heart J Imaging Methods Pract

April 2024

Department of Cardiology, Erasmus MC, Cardiovascular Institute, Thorax Center, Rotterdam, The Netherlands.

Aims: By combining temporal changes in left ventricular (LV) global longitudinal strain (GLS) with LV volume, LV strain-volume loops can assess cardiac function across the cardiac cycle. This study compared LV strain-volume loops between bicuspid aortic valve (BAV) patients and controls, and investigated the loop's prognostic value for clinical events.

Methods And Results: From a prospective cohort of congenital heart disease patients, BAV patients were selected and compared with healthy volunteers, who were matched for age and sex at group level.

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Article Synopsis
  • - The study investigates how advanced transthoracic echocardiography (TTE) measures of right ventricular (RV) function correlate with cardiovascular magnetic resonance (CMR) findings in adults with congenital heart disease (ACHD).
  • - It includes 100 stable ACHD patients and highlights that while advanced echocardiographic techniques provide useful data, only about half of the participants had measurable RV parameters, with conventional TTE metrics showing poor correlation with CMR results.
  • - The results reveal that advanced RV indices correlate moderately with CMR-derived RV ejection fraction (CMR-RVEF), but there are significant differences in values obtained from CMR compared to TTE, indicating the need for careful interpretation when using these methods in
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