The Global Temperament Project: Parent-reported temperament in infants, toddlers, and children from 59 nations.

Data from 83,423 parent reports of temperament (surgency, negative affectivity, and regulatory capacity) in infants, toddlers, and children from 341 samples gathered in 59 countries were used to investigate the relations among culture, gender, and temperament. Between-nation differences in temperament were larger than those obtained in similar studies of adult personality, and most pronounced for negative affectivity. Nation-level patterns of negative affectivity were consistent across infancy, toddlerhood, and childhood, and patterns of regulatory capacity were consistent between infancy and toddlerhood.

glycan biosynthesis modulates host immune cell recognition and response.

Introduction: The pathogenic bacterium has evolved glycan-mediated mechanisms to evade host immune defenses. This study tests the hypothesis that genetic disruption of glycan biosynthesis alters immune recognition and response by human gastric epithelial cells and monocyte-derived dendritic cells.

Methods: To test this hypothesis, human cell lines were challenged with wildtype alongside an array of glycosylation mutants.

Lake water chemistry and local adaptation shape NaCl toxicity in .

The increasing application of road deicing agents (e.g., NaCl) has caused widespread salinization of freshwater environments.

A short executive functioning questionnaire in the context of early childhood screening: psychometric properties.

Early childhood executive functioning (EF) predicts later adjustment and academic achievement. However, measuring EF consistently and efficiently across settings in early childhood can be challenging. Most researchers use task-based measures of EF, but these methods present practical challenges that impede implementation in some settings.

Blocking endogenous retinoic acid degradation induces oral tooth formation in zebrafish.

According to Dollo's Law of irreversibility in evolution, a lost structure is usually considered to be unable to reappear in evolution due to the accumulation over time of mutations in the genes required for its formation. Cypriniform fish are a classic model of evolutionary loss because, while they form fully operational teeth in the ventral posterior pharynx, unlike other teleosts, they do not possess oral teeth. Paleontological data show that Cypriniforms, a clade of teleost fish that includes the zebrafish, lost their oral teeth 50 to 100 Mya.

Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype.

Rationale: Arginine vasopressin (AVP) has dose- and sex-specific effects on social behavior, and variation in social responses is related to variation in the V1a receptor gene in animals. Whether such complexity also characterizes AVP effects on anxiety in humans, or whether V1a genotype is related to anxiety and/or AVP's ability to affect it, remains to be determined.

Objective: To test if AVP has dose-dependent effects on anxiety in men and/or women and if a particular allele within the RS3 promoter region of the V1a receptor gene is associated with anxiety and/or AVP effects on anxiety.

Early life adversity drives sex-dependent changes in 5-mC DNA methylation of parvalbumin cells in the prefrontal cortex in rats.

Early life adversity (ELA) can result in increased risk for developing affective disorders, such as anxiety or depression, later in life, with women showing increased risk. Interactions between an individual's genes and their environment play key roles in producing, as well as mitigating, later life neuropathology. Our current understanding of the underlying epigenomic drivers of ELA associated anxiety and depression are limited, and this stems in part from the complexity of underlying biochemical processes associated with how early experiences shapes later life behavior.

Genome-wide association with footrot in hair and wool sheep.

Ovine footrot is an infectious disease with important contributions from and . Footrot is characterized by separation of the hoof from underlying tissue, and this causes severe lameness that negatively impacts animal wellbeing, growth, and profitability. Large economic losses result from lost production as well as treatment costs, and improved genetic tools to address footrot are a valuable long-term goal.

Drug Repositioning of Metformin Encapsulated in PLGA Combined with Photothermal Therapy Ameliorates Rheumatoid Arthritis.

Purpose: Rheumatoid arthritis (RA) is a highly prevalent form of autoimmune disease that affects nearly 1% of the global population by causing severe cartilage damage and inflammation. Despite its prevalence, previous efforts to prevent the perpetuation of RA have been hampered by therapeutics' cytotoxicity and poor delivery to target cells. The present study exploited drug repositioning and nanotechnology to convert metformin, a widely used antidiabetic agent, into an anti-rheumatoid arthritis drug by designing poly(lactic-co-glycolic acid) (PLGA)-based spheres.

forager: a Python package and web interface for modeling mental search.

Analyzing data from the verbal fluency task (e.g., "name all the animals you can in a minute") is of interest to both memory researchers and clinicians due to its broader implications for memory search and retrieval.

Bradysia (Sciara) coprophila larvae up-regulate DNA repair pathways and down-regulate developmental regulators in response to ionizing radiation.

The level of resistance to radiation and the developmental and molecular responses can vary between species, and even between developmental stages of one species. For flies (order: Diptera), prior studies concluded that the fungus gnat Bradysia (Sciara) coprophila (sub-order: Nematocera) is more resistant to irradiation-induced mutations that cause visible phenotypes than the fruit fly Drosophila melanogaster (sub-order: Brachycera). Therefore, we characterized the effects of and level of resistance to ionizing radiation on B.

Effect of cyano-addition on the photoacidity switch in 5-cyano-8-amino-2-naphthol.

Cyano- or CN-additions are often utilized in the design of photoacids to enhance and/or enable excited state proton transfer (ESPT) from the protic site to aqueous and nonaqueous solvents. In diprotic photoacid 8-amino-2-naphthol (8N2OH), the protonation state of the amino group (NH/NH) acts as an on-off switch for ESPT at the OH site in water. This study investigated whether the addition of CN in 5-cyano-8-amino-2-naphthol (5CN8) could override this switch and promote new ESPT pathways.

Post-Acute Sequelae of COVID-19 (PASC) in Pediatrics: Factors That Impact Symptom Severity and Referral to Treatment.

The post-acute sequelae of COVID-19 (PASC) is a complex condition. While there are emerging studies on its effects in adults, there is scarce research regarding the long-term effects of COVID-19 infection among youth. Several researchers have likened long-haul COVID-19 to chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and postural orthostatic tachycardia syndrome (POTS).

Inter-colony variation in predation, mercury burden and adult survival in a declining seabird.

Migratory species with disjunct and localized breeding distributions, including many colonial marine birds, pose challenges for management and conservation as their dynamics are shaped by both broad oceanographic changes and specific factors affecting individual breeding colonies. We compare six colonies of the declining Leach's storm-petrel, Hydrobates leucorhous, across their core range in Atlantic Canada using standard capture-mark-recapture methods to estimate annual survival of individually marked populations of breeding adults. Over the period analysed (5-20 years per colony; 2003-2022), mean annual survival varied among colonies (0.

Critical Phenomena in the Collapse of Gravitational Waves.

Fine-tuning generic but smooth spherically symmetric initial data for general relativity to the threshold of dynamical black hole formation creates arbitrarily large curvatures, mediated by a universal self-similar solution that acts as an intermediate attractor. For vacuum gravitational waves, however, these critical phenomena have been elusive. We present, for the first time, excellent agreement among three independent numerical simulations of this collapse.

Transvection between nonallelic genomic positions in Drosophila.

In Drosophila, pairing of maternal and paternal homologous chromosomes can permit trans-interactions between enhancers on one homolog and promoters on another, an example of transvection. Although trans-interactions have been observed at many loci in the Drosophila genome and in other organisms, the parameters that govern enhancer action in trans remain poorly understood. Using a transgenic reporter system, we asked whether enhancers and promoters at nonallelic, but nearby, genomic positions can communication in trans.

Golgi ELMO1 binds QUA1, QUA2, GAUT9, and ELMO4 and is required for pectin accumulation in Arabidopsis.

Pectin and its modification influence the plasticity and strength of the plant cell wall controlling cell adhesion, size, shape, and pathogen resistance. The Golgi membrane anchored QUA1, QUA2, and GAUT9 Golgi enzymes synthesize and esterify pectin, which is then secreted and selectively de-esterified to potentiate structure influencing crosslinks in the cell wall. Mutations in members of the family of non-enzymatic ELMO Golgi membrane proteins lead to a reduction of pectin levels, cell adhesion, and hypocotyl tensile strength.

Diversity of neuropeptidergic modulation in decapod crustacean cardiac and feeding systems.

All nervous systems are multiply modulated by polypeptides. However, a bulk of transmitter and modulation research has historically focused on small molecule transmitters released at synaptic sites. The stomatogastric nervous system (controls digestive movements of the foregut) and cardiac nervous system of decapod crustaceans have long been used to understand the processes that underlie neuromodulation.

Natural climate solutions provide robust carbon mitigation capacity under future climate change scenarios.

Natural climate solutions (NCS) are recognized as an important tool for governments to reduce greenhouse gas emissions and remove atmospheric carbon dioxide. Using California as a globally relevant reference, we evaluate the magnitude of biological climate mitigation potential from NCS starting in 2020 under four climate change scenarios. By mid-century NCS implementation leads to a large increase in net carbon stored, flipping the state from a net source to a net sink in two scenarios.

The role of theta and gamma oscillations in item memory, source memory, and memory confidence.

Theta and gamma oscillations have been linked to episodic memory processes in various studies. Both oscillations seem to be vital for processes guided by the medial temporal lobe, such as the retrieval of information from memory. While theta oscillations increase with successful memory, it is unclear what the unique contribution of theta is to various subcomponents of memory.

RAI-measured frailty predicts non-home discharge following metastatic brain tumor resection: national inpatient sample analysis of 20,185 patients.

Purpose: Preoperative risk stratification for patients undergoing metastatic brain tumor resection (MBTR) is based on established tumor-, patient-, and disease-specific risk factors for outcome prognostication. Frailty, or decreased baseline physiologic reserve, is a demonstrated independent risk factor for adverse outcomes following MBTR. The present study sought to assess the impact of frailty, measured by the Risk Analysis Index (RAI), on MBTR outcomes.

Playback of rat 22-kHz ultrasonic vocalizations as a translational assay of negative affective states: An analysis of evoked behavior and brain activity.

The subjective nature of human emotions makes them uniquely challenging to investigate in preclinical models. While behavioral assays in rodents aim to evaluate affect (i.e.

Poor Generalization by Current Deep Learning Models for Predicting Binding Affinities of Kinase Inhibitors.

The extreme surge of interest over the past decade surrounding the use of neural networks has inspired many groups to deploy them for predicting binding affinities of drug-like molecules to their receptors. A model that can accurately make such predictions has the potential to screen large chemical libraries and help streamline the drug discovery process. However, despite reports of models that accurately predict quantitative inhibition using protein kinase sequences and inhibitors' SMILES strings, it is still unclear whether these models can generalize to previously unseen data.