1,043 results match your criteria: "Bourguiba University Hospital[Affiliation]"

Outcomes of peripartum cardiomyopathy in North Africa: insights from a single-center observational study in Tunisia.

BMC Pregnancy Childbirth

November 2024

Department of Gynecology and Obstetrics, Faculty of Medicine, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.

Article Synopsis
  • - Peripartum cardiomyopathy (PPCM) is a rare and serious heart condition often occurring during or after pregnancy; this study assessed its outcomes in North Africa over a 12-year period from 2010 to 2022.
  • - Out of 27 PPCM patients studied, most presented symptoms like severe dyspnea and had a low average heart function measurement (LVEF of 30%); complications included pulmonary edema (85%) and the need for ECMO support in two patients.
  • - The follow-up revealed that 67% of patients showed recovery in heart function, but the overall mortality rate was 15%, with significant mortality associated with factors like past pregnancies and poor prenatal care.
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Pseudoglandular hyperplasia of the conjunctiva: A rare entity.

J Fr Ophtalmol

January 2025

Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia. Electronic address:

Objective: Pseudoglandular hyperplasia of the conjunctiva (PHC) is a rare benign epithelial pseudotumor. We report herein a new case of this rare entity, review its histopathological features and discuss its differential diagnoses.

Methods: The morphologic findings of PHC of the right eye occurring in a 65-year-old man are reported with a review of the related literature.

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Introduction: Ensuring optimal blood transfusion practices relies on a robust expertise base that is indispensable across various professional fields. Recognizing this imperative, the current study aims to assess the knowledge levels of healthcare personnel and enhance transfusion quality through targeted continuing training initiatives.

Methods: The preliminary survey was based on an anonymous questionnaire and we used correct response rate (CRR) as the main parameter evaluating the baseline level of knowledge.

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Unlabelled: The prevalence of infections caused by extended-spectrum beta-lactamase (ESBL)-producing (ESBL-EC) and carbapenemase-producing (CP-EC) is increasing worldwide. We investigated the epidemiology of ESBL-EC and CP-EC causing hospital-acquired (HA) infections in a large teaching hospital in Tunisia over the last two decades and compared it with a collection of 107 community-acquired (CA) ESBL-EC isolates. Between 2001 and 2019, the incidence of HA ESBL-EC increased significantly from 0.

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Background: Visceral Leishmaniasis (VL) is the most severe and fatal disease if left untreated. In people living with HIV/AIDS (PLHA), VL is considered an emerging opportunistic infection. The aim of this manuscript was to report a first case in Tunisia of a concomitant presentation of visceral and oral leishmaniasis in a patient LHA.

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[Not Available].

Tunis Med

October 2024

Ophthalmology Department, Fattouma Bourguiba University Hospital, Monastir. Faculty of Medicine of Monastir, University of Monastir, Tunisia.

Article Synopsis
  • The study aimed to analyze microvascular changes around the optic nerve in patients with optic neuropathies using optical coherence tomography angiography (OCTA).
  • During the research, 63 eyes from patients with various optic neuropathy causes were compared to 36 healthy eyes, revealing more vascular changes in acute non-arteritic ischemic optic neuropathy than in optic neuritis.
  • Results indicated that a lower peripapillary vascular density (PVD) was linked to optic atrophy and hypertension, with some correlations between visual acuity and PVD, highlighting significant changes in microvasculature related to the condition and systemic health factors.
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Introduction: Cleft lip and palate (CLP) is the most common congenital malformation of the head and neck. Children with CLP often exhibit dental anomalies.

Aim: To evaluate the dental age (DA) of unilateral CLP in Tunisian children.

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Benefits of self-paced concurrent training on lung function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis.

Neurodegener Dis Manag

October 2024

Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisia.

Studying the effects of self-paced concurrent high-intensity interval training and resistance training (HIIT-RT) on respiratory function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis (PwMS). Twenty-three PwMS were randomized into a 12-week training group (three times per week) (TG, n = 11) or a control group (CG, n = 12). Lung function (spirometry), aerobic capacity (graded cardiopulmonary-exercise-testing) and perceived fatigue (Fatigue Severity Scale (FSS)) were evaluated pre- and post-intervention.

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Article Synopsis
  • Intracranial infections after neurosurgery can lead to serious health risks, including high rates of illness and death.
  • The article describes a unique case of an infection caused by a rare gram-negative bacteria in a healthy adult using external ventricular drains.
  • It discusses the treatment approach, which included a 21-day intravenous antibiotic regimen with meropenem and vancomycin, highlighting the difficulties in managing such rare complications.
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Triple-negative breast cancer (TNBC) is known to have the worst outcome compared to the other forms of breast cancer. Moreover, molecular markers identified basal-like breast cancer (BLBC) phenotypes to be also related to a worse prognosis. In this study, we evaluated by immunohistochemistry (IHC) the prognostic significance of combining Cytokeratin-19 (CK19), E-cadherin, and Ki-67 tissue expression in triple-negative breast cancer (TNBC) cases presenting a basal-like (BLBC) or a non-basal-like (n-BLBC) phenotype to improve the selection and the monitoring of BC patients with a more aggressive outcome.

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Objective: To examine outcomes and associated risk factors for children who undergo surgery for lung hydatidosis (LH).

Study Design: Through a retrospective and analytical-aim-study, over a period of 35 years in 2 surgical departments, we reported all operative cases for LH in children, regardless of cyst number, location, and aspect. Univariate and multivariable analyses were used to assess variables potentially predictive of postoperative morbidity.

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Article Synopsis
  • Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder that causes extremely high LDL cholesterol levels, leading to heart disease at an early age; lomitapide is a medication designed to lower these cholesterol levels in affected adults and is being tested for safety and efficacy in children.
  • The APH-19 study involved 43 pediatric patients aged 5-17 years on existing cholesterol treatments; they received varying doses of lomitapide over a 24-week period to measure its effect on LDL cholesterol levels and other lipid parameters.
  • Results indicated a significant decrease in LDL cholesterol by 53.5% after 24 weeks of treatment, suggesting lomitapide may be effective for managing cholesterol
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Differential diagnoses and therapeutic features of giant cell tumor of the bone in an elderly patient: A case report.

Int J Surg Case Rep

November 2024

Trauma and orthopedics Department, Faculty of Medicine, Fattouma Bourguiba University Hospital, University of Monastir - 1, 1st of June Street, Monastir 5000, Tunisia.

Article Synopsis
  • Giant cell tumors of the bone typically affect young adults, but this case highlights diagnosis and treatment considerations for older patients.
  • A 73-year-old man with GCT in his knee had successful treatment via extensive curettage and bone grafting, leading to good long-term outcomes.
  • In older patients, differential diagnosis with other conditions is crucial, and while joint-replacing surgeries are common, joint-preserving options can also be effective if osteoarthritis is not present.
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Eight weeks of oral iron supplementation improves postural control in young women with iron deficiency anemia.

Eur J Clin Nutr

October 2024

Research Laboratory Education, Motricité, Sport et Santé, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, 3000, Sfax, Tunisia.

Objective: This study aimed to explore the effect of 8-week oral supplementation on postural control in young women with iron deficiency anemia (IDA).

Methods: This study involved 15 women with IDA who received 160 mg of elemental iron daily in the form of dried ferrous sulfate capsules (80 mg twice daily) taken in two divided doses for 8 weeks. The mean velocity of oscillations of the center of pressure (CoPv) was recorded to evaluate postural control pre- and post-supplementation.

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Cardiovascular clinical trials continue to under-represent children, older adults, females and people from ethnic minority groups relative to population disease distribution. Here we describe strategies to foster trial representativeness, with proposed actions at the levels of trial funding, design, conduct and dissemination. In particular, trial representativeness may be increased through broad recruitment strategies and site selection criteria that reflect the diversity of patients in the catchment area, as well as limiting unjustified exclusion criteria and using pragmatic designs that minimize research burden on patients (including embedded and decentralized trials).

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Article Synopsis
  • * A 60-year-old man with relevant medical conditions presented with severe abdominal pain and vomiting, eventually diagnosed with pancreatitis associated with a hydatid cyst after imaging and lab tests.
  • * The patient underwent surgery for the cyst, which was confirmed through histopathology, and post-operative recovery was successful, with a follow-up treatment of antibiotics recommended for prevention.
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The gut-eye axis: the retinal/ocular degenerative diseases and the emergent therapeutic strategies.

Front Cell Neurosci

September 2024

Genomics of Signalopathies at the Service of Precision Medicine LR23ES07 FMS, University of Sfax, Sfax, Tunisia.

Article Synopsis
  • - The gut microbiota significantly impacts human health, particularly through the gut-brain axis, and has been linked to various eye disorders, including age-related macular degeneration.
  • - Recent research has introduced the concept of the gut-retina axis, highlighting how disruptions in gut microbiota could lead to retinal damage and other ocular issues.
  • - This review explores the mechanisms behind the gut-eye axis and suggests possible therapeutic interventions for eye diseases, emphasizing the need for further research in this area.
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Myocardial Ischemia after Severe Scorpion Envenomation: A Narrative Review.

Am J Trop Med Hyg

December 2024

Department of Intensive Care, Habib Bourguiba University Hospital, Sfax University, Sfax, Tunisia.

Article Synopsis
  • Severe scorpion envenomation can lead to temporary myocardial ischemia, which is rarely reported but supported by various studies, including electrocardiograms and echocardiography.
  • This myocardial hypoperfusion may arise from catecholamine storms causing microvascular constriction and other neurohormonal interactions that contribute to cardiac fiber damage.
  • Management includes providing oxygen and ventilator support, and while dobutamine can aid cardiac function, antiplatelet therapy is not recommended.
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Article Synopsis
  • The study investigated the characteristics of central nervous system rickettsial infections in patients hospitalized with rickettsiosis over 25 years in Tunisia.
  • Out of 440 patients, 47 had neurological symptoms, showing that skin rashes and eschars were less common in these cases, along with a higher rate of complications and mortality.
  • The findings suggest that typical symptoms and lab results were less pronounced in central nervous system cases, indicating a more severe prognosis.
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Purpose: Social media (SM) has become a common activity for today's young people. It is sometimes overused and potentially results in SM addiction. This study aims to assess SM addiction and its associated factors in medical students and to examine its relationship with dimensions of personality global self-esteem, and social self-esteem.

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Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
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Oropharyngeal Lipoma: A Rare Case of Dysphagia.

Ear Nose Throat J

September 2024

ENT Department and Research Laboratory LR23ES01, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.

Lipomas are benign and slow-growing neoplasms that typically develop in the subcutaneous tissue. They rarely occur in the upper aerodigestive tract. Oropharyngeal lipomas are rare.

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Multi-modality imaging to assess rheumatic mitral stenosis severity.

Int J Cardiovasc Imaging

November 2024

Cardiology A Department, Research Laboratory LR12 SP 16 Fattouma Bourguiba University Hospital, University of Monastir, Rue du 1er juin 1955, Monastir, 5000, Tunisia.

Multi-modality imaging is the recommended approach to assess the severity of valvular heart diseases. Rheumatic mitral stenosis (MS), however, has yet to benefit from this approach. The aim of this study is to assess the added value of cardiac MRI (CMR) and computed tomography (CT) calcium score in assessing severity of MS when compared to 3D echocardiography.

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Parathyroid Carcinomas: A Series of 6 Cases and Literature Review.

Ear Nose Throat J

September 2024

ENT Department and Research Laboratory LR23ES01, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.

Parathyroid carcinoma (PC) is a rare endocrine malignancy. We report 6 cases of PCs operated on in our department, during a period of 12 years (2010-2021). All of our patients presented severe hyperparathyroidism, high calcium levels, and very elevated parathormone (PTH) rates.

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