1 results match your criteria: "Boul. de L'Université Chicoutimi Québec Canada G7H 2B1 andre.pichette@uqac.ca.[Affiliation]"
Synthesis, cytotoxicity and anti-inflammatory activity of rhamnose-containing ursolic and betulinic acid saponins.
RSC Adv
December 2019
Centre de Recherche sur La Boréalie (CREB), Chaire de Recherche sur Les Agents Anticancéreux D'origine Naturelle, Laboratoire LASEVE, Département des Sciences Fondamentales, Université du Québec à Chicoutimi 555, Boul. de L'Université Chicoutimi Québec Canada G7H 2B1
Betulinic acid and ursolic acid are ubiquitous, naturally-occurring triterpenoids exhibiting various pharmacological activities including cytotoxic and anti-inflammatory activities. However, these triterpenoids display unfavorable pharmacokinetic properties as well as low aqueous solubility. It has been shown that the presence of α-l-rhamnose moieties positively modulates the anticancer activity of secondary metabolites.
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