315 results match your criteria: "Botanical Dermatology"
Effect of Small-Molecule Natural Compounds on Pathologic Mast Cell/Basophil Activation in Allergic Diseases.
Cells
December 2024
Division of R&D, General Nutraceutical Technology LLC, Elmsford, NY 10523, USA.
Pathologic mast cells and basophils, key effector cells in allergic reactions, play pivotal roles in initiating and perpetuating IgE-mediated allergic responses. Conventional therapies for allergies have limitations, prompting exploration into alternative approaches such as small-molecule natural compounds derived from botanical sources. This review synthesizes the existing literature on the effects of these compounds on pathologic mast cells and basophils, highlighting their potential in allergy management, and utilizes the PubMed database for literature acquisition, employing keyword-based searches to identify relevant peer-reviewed sources.
View Article and Find Full Text PDFFrom Plant to Patient: A Historical Perspective and Review of Selected Medicinal Plants in Dermatology.
JID Innov
January 2025
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA.
Skin conditions are a common health concern faced by patients of all ages. For thousands of years, plants have been used to treat various skin conditions, including acne, vitiligo, and psoriasis, to name a few. Today, with increasing patient preference for natural therapies, modern medicine is now more than ever incorporating age-old knowledge of herbal remedies useful in treating skin conditions into modern-day treatments.
View Article and Find Full Text PDFA review of the efficacy of complementary and alternative Medicines in managing Pruritus.
Arch Dermatol Res
December 2024
School of Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.
Background: Pruritus significantly impacts quality of life, leading to increased interest in complementary and alternative medicines (CAMs) as potential treatments. This review explores the efficacy of various CAMs for pruritus.
Methods: A comprehensive review was conducted on the effectiveness of several CAMs for pruritus.
Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology.
J Clin Microbiol
December 2024
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Article Synopsis
Eudermic Properties and Chemical-Physical Characterization of Honeys of Different Botanical Origin.
Nutrients
October 2024
Department of Physics, Earth and Environmental Sciences, University of Siena, 53100 Siena, Italy.
Honey is a natural product that, thanks to its composition, particularly the high sugar content, is highly appreciated as an energy nourishment. In addition to sugars, it contains many other substances (carbohydrates, free amino acids, enzymatic proteins, organic acids, polyphenols) from which the therapeutic properties of honey arise: hydrating and osmotic activity, antimicrobial action, and antioxidant and anti-inflammatory power. The present work aims to deepen our knowledge/understanding of the activity of skin protection exerted by honey, as a synergic result of its multiple therapeutic effects.
View Article and Find Full Text PDFPotential for Allergic Contact Dermatitis in Popular Depilatory Wax Hair Removal Practices and Ingredients.
Dermatitis
November 2024
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- - Allergic contact dermatitis (ACD) can result from allergens found in personal care and cosmetic products, particularly in depilatory waxing items used at salons and available online.
- - The study analyzed ingredients from salon products and top online wax products, identifying common allergens like vitamin E, colophony, and botanicals, which were present at varying rates among the products examined.
- - Recognizing these allergens is important for ensuring safety during hair removal procedures, as they may cause reactions, even if they don’t frequently result in ACD.
Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts.
Biomolecules
October 2024
Epigenetics of Aging, Department of Dermatology and Allergy, TUM School of Medicine, Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich (TUM), 85748 Garching, Germany.
The human skin, the body's largest organ, undergoes continuous renewal but is significantly impacted by aging, which impairs its function and leads to visible changes. This study aimed to identify botanical compounds that mimic the anti-aging effects of baricitinib, a known JAK1/2 inhibitor. Through in silico screening of a botanical compound library, 14 potential candidates were identified, and 7 were further analyzed for their effects on cellular aging.
View Article and Find Full Text PDFTreatment-refractory granulomatous reaction to microneedling with transepidermal drug delivery of vitamin C, niacinamide, and botanical extracts.
Int J Dermatol
October 2024
Meridian Dermatology, Meridian, Idaho, USA.
An Oral Botanical Supplement Improves Small Intestinal Bacterial Overgrowth (SIBO) and Facial Redness: Results of an Open-Label Clinical Study.
Nutrients
September 2024
Integrative Skin Science and Research, Sacramento, CA 95815, USA.
Article Synopsis
- - The study investigates the effects of an herbal treatment on gut microbiome, facial redness, and intestinal permeability in adults diagnosed with small intestinal bacterial overgrowth (SIBO) confirmed by a lactulose breath test.
- - Participants underwent a 10-week regimen of a Biocidin liquid tincture and GI Detox+, with additional treatment via Olivirex if they showed no improvement, monitored through breath tests and other analyses.
- - Results indicated that the herbal regimen was particularly effective for certain types of SIBO, with 42.8% of participants showing improvement in hydrogen-dominant cases and significant increases in beneficial bacteria over the treatment period.
Plants and their uses in dermatological recipes of the Receptarium of Burkhard III von Hallwyl from 16th century Switzerland - Data mining a historical text and preliminary in vitro screening.
J Ethnopharmacol
December 2024
ZHAW Zurich University of Applied Sciences, School of Life Sciences and Facility Management, Institute of Chemistry and Biotechnology, Natural Product Chemistry and Phytopharmacy Group, Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland; Pro Thesauro Sanitatis (PTS), c/o Thomas Frei, Kappelen 20, 5706, Boniswil, Switzerland. Electronic address:
Article Synopsis
- Historical texts on materia medica are valuable for ethnopharmacological insights, but converting this information into usable data sets is challenging.
- The study aims to catalog pharmacobotanical information from Burkhard von Hallwyl's Receptarium to identify plants for further pharmacological research.
- A relational database was created to analyze dermatological recipes, and candidate plants were screened in vitro for their effects on inflammatory skin disorders using extracts from plants collected in Switzerland.
Unlocking the psycho-social-dermal axis: A double blinded randomized placebo controlled study unveiling the influence of a novel topical formulation on skin quality, attractiveness, quality of life, and sexual satisfaction.
J Cosmet Dermatol
September 2024
Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, University of Illinois at Chicago, Chicago, Illinois, USA.
Article Synopsis
- Improved skin appearance can boost self-esteem and positively influence social interactions, making effective skincare products valuable for both skin health and psychological well-being.
- A study involving 40 women showed that using a new skincare product containing proteins, lipids, and botanicals for 4-8 weeks significantly improved skin quality and self-confidence.
- Participants using the product reported feeling younger, more attractive, and more satisfied in their romantic relationships compared to those using a placebo.
Botanical extract combined with minoxidil improve hidrotic ectodermal dysplasia caused by p.G11R mutations: a case report.
J Dermatolog Treat
December 2024
Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Article Synopsis
- * The boy received a combination treatment of botanical extracts and Minoxidil, leading to significant hair growth after one and a half months.
- * This case suggests that botanical extracts may be a viable option for treating hair loss in children, offering insights for future research on similar treatments for congenital alopecia.
Rosin: A comprehensive review on traditional uses, phytochemistry, and pharmacology.
Fitoterapia
September 2024
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Article Synopsis
- Rosin, derived from conifer trees, has a rich history in traditional medicine for treating various ailments like wounds and burns across cultures, including ancient Egypt and China.
- A review of rosin explores its traditional uses, chemical makeup, and potential health benefits, noting that over 90% of its compounds are rosin acids, with around 50 different compounds identified.
- Despite promising pharmacological activities such as antimicrobial and anti-inflammatory effects, the review stresses the need for more research to validate these findings and understand the mechanisms behind rosin's therapeutic properties.
Management of androgenic alopecia: a systematic review of the literature.
J Cosmet Laser Ther
August 2024
Department of Dermatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
We aimed to determine the efficacy of the various available oral, topical, and procedural treatment options for hair loss in individuals with androgenic alopecia. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic review of the National Library of Medicine was performed. Overall, 141 unique studies met our inclusion criteria.
View Article and Find Full Text PDFBotanical Briefs: Fig Phytophotodermatitis (Ficus carica).
Cutis
April 2024
Drs. Barker and Elston are from the Medical University of South Carolina, Charleston. Dr. Barker is from the Department of Internal Medicine, and Dr. Elston is from the Department of Dermatology and Dermatologic Surgery. Dr. McGovern is from Fort Wayne Dermatology Consultants, Indiana.
Article Synopsis
- Patients with a linear, red blistering rash may suffer from a painful sunburn effect that worsens over time.
- In warmer climates, exposure to fig trees (Ficus carica) can lead to this skin reaction.
- Dermatologists need to identify fig phytophotodermatitis as a potential cause and provide appropriate treatment while helping patients understand the relationship between their symptoms and the fig tree.
Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells.
Antioxidants (Basel)
April 2024
Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Article Synopsis
- Cannabis and its major cannabinoid, cannabidiol (CBD), show potential anticancer effects against skin tumors, particularly melanoma.
- In experiments, CBD exhibited significant cytotoxicity, with IC values of 28.6 and 51.6 μM against murine (B16F10) and human (A375) melanoma cells, respectively.
- Synthetic CBD derivatives with bipiperidinyl groups demonstrated even greater cytotoxicity, suggesting that these compounds could be effective in treating melanoma by inducing apoptosis in cancer cells.
Botanical Briefs: Contact Dermatitis Induced by Western Poison Ivy (Toxicodendron rydbergii).
Cutis
January 2024
Shawn Afvari is from New York Medical College School of Medicine, Valhalla. Dr. Elston is from the Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston. Dr. McGovern is from Fort Wayne Dermatology Consultants, Indiana.
Article Synopsis
- "Leaves of three, leave it be" is a warning against poison ivy, which can cause skin rashes due to its harmful sap.
- Toxicodendron contact dermatitis (TCD) affects around half a million people in the US each year, creating a significant health care challenge.
- The article covers how to identify poison ivy, its symptoms, and treatment options after exposure.
Botanical Briefs: Neem Oil (Azadirachta indica).
Cutis
January 2024
Nina Patel is from the Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois. Drs. Knabel and Speiser and from the Loyola University Medical Center, Maywood. Dr. Knabel is from the Division of Dermatology, and Dr. Speiser is from the Department of Pathology.
Article Synopsis
- Neem (Azadirachta indica) is recognized for its various applications as a natural remedy, especially in disease management.
- The text reviews neem's pharmacological, biological, and medicinal properties.
- A rare case is discussed where a 77-year-old man developed a hypopigmented rash after using neem oil for 6 months to treat arthritis and lower back pain.
Rosemary extract and rosmarinic acid accelerate elastic fiber formation by increasing the expression of elastic fiber components in dermal fibroblasts.
J Dermatol
June 2024
Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Article Synopsis
- Ultraviolet (UV) radiation contributes to skin aging by breaking down collagen and elastic fibers, leading to loss of skin elasticity.
- Microfibril-associated protein 4 (MFAP-4) is crucial for forming elastic fibers and is reduced in photoaged skin, but increasing its levels can help protect against UV damage.
- Rosemary extract, particularly its component rosmarinic acid, enhances MFAP-4 expression and promotes the formation of elastic fibers, suggesting it could help prevent or improve skin aging effects from UV exposure.
Reply to Kidd et al., "Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion".
J Clin Microbiol
April 2024
International Society for Human and Animal Mycology (ISHAM), Working Group Nomenclature, 's-Hertogenbosch, the Netherlands.
Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019-2022 prospective study with cluster and network analysis.
J Eur Acad Dermatol Venereol
February 2024
Department of Dermatology, Hospital del Mar Research Institute, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Article Synopsis
- A multicentric study in Spain analyzed data from 10,176 patients over four years to explore polysensitization (PS), finding that 8.3% of participants were polysensitized.
- Factors associated with PS included older age, atopic dermatitis, and exposure at specific body locations, with significant differences in allergen relevance compared to those with fewer sensitivities.
- The research revealed distinct allergen clusters among polysensitized patients, suggesting that cross-reactivity and sensitization may contribute to these patterns.
Research advances of polyphenols in inflammatory diseases.
Front Immunol
February 2024
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- Chinese prickly ash is a spice and traditional medicine known for treating inflammation and has a long history of use.
- The review explores its botanical classification, traditional uses, and emphasizes the anti-inflammatory properties of its polyphenolic components, which show therapeutic promise in preclinical studies.
- Despite the potential benefits for various inflammatory diseases, more research is needed to understand how these compounds work and to create safe treatments.
Mānuka oil based ECMT-154 versus vehicle control for the topical treatment of eczema: study protocol for a randomised controlled trial in community pharmacies in Aotearoa New Zealand.
BMC Complement Med Ther
January 2024
Medical Research Institute of New Zealand, Wellington, Aotearoa, New Zealand.
Article Synopsis
- Eczema is a common skin condition typically treated with emollients and topical corticosteroids, but there is a growing interest in botanical therapies despite limited clinical evidence.
- A randomized controlled trial (RCT) is being conducted to test the safety and effectiveness of a mānuka oil-based emollient cream (2% ECMT-154) for moderate to severe eczema, involving 118 participants in New Zealand who will apply the cream for six weeks.
- The study's results will evaluate symptom improvement and treatment acceptability, with findings shared through publications and presentations if the therapy proves effective.
Effectiveness and tolerance of multicorrective topical treatment for infraorbital dark circles and puffiness.
J Cosmet Dermatol
February 2024
Revision Skincare®, Irving, Texas, USA.
Article Synopsis
- The treatment of dark circles and under-eye puffiness is complex and there's a need for better skincare solutions that are effective for diverse patients.
- A study tested a new eye cream, MTEC, which includes ingredients like vitamin C, peptides, and caffeine, to see if it could improve these issues by targeting skin health and pigmentation.
- Results showed that the MTEC significantly improved the appearance of dark circles and puffiness among various participants, making it a promising treatment option.
Botanical Briefs: Australian Stinging Tree (Dendrocnide moroides).
Cutis
November 2023
Dr. DeVore is from the Medical University of South Carolina, Charleston. Dr. McGovern is from Fort Wayne Dermatology Consultants, Indiana. The authors report no conflict of interest.
Article Synopsis
- Dendrocnide moroides, commonly called gympie-gympie, is a highly dangerous stinging plant that can cause severe pain and even death in rare cases.
- The plant features heart-shaped, serrated dark green leaves covered in fine hair and produces reddish to dark purple fruit on long stems.
- Symptoms from contact include intense pain and swelling that may last from one hour to several months, with hair removal wax strips recommended for first aid treatment.