2 results match your criteria: "Boston University and NHLBI's Framingham Study Framingham MA.[Affiliation]"
Background Systolic blood pressure increases with age after midlife, particularly in women, and contributes to development of wide pulse pressure hypertension in middle-aged and older adults. Relative contributions of aortic stiffness and premature wave reflection to increases in pulse pressure remain controversial. Methods and Results We evaluated visit-specific values and change in key correlates of pulse pressure, aortic characteristic impedance, forward and backward wave amplitude, and global reflection coefficient, at 3 sequential examinations of the Framingham Generation 3 (N=4082), Omni-2 (N=410), and New Offspring Spouse (N=103) cohorts (53% women).
View Article and Find Full Text PDFWindkessel Measures Derived From Pressure Waveforms Only: The Framingham Heart Study.
J Am Heart Assoc
July 2019
1 Cardiovascular Engineering, Inc. Norwood MA.
Article Synopsis
- Background Waveform parameters from Windkessel models may help assess cardiovascular disease risk, as shown in a study using data from the Framingham Heart Study with 2,539 participants.
- The analysis linked the nonlinear model-derived systolic time constant (τ) and reservoir pressure amplitude to cardiovascular events, indicating their potential use in risk stratification.
- However, linear model parameters did not show significant associations with cardiovascular events, highlighting the need for further validation of these findings.