4 results match your criteria: "Boston University Chobian & Avedisian School of Medicine[Affiliation]"
Statistical Methods to Examine Racial and Ethnic Disparities in the Surgical Literature: A Review and Recommendations for Improvement.
Ann Surg
December 2024
Stanford-Surgery Policy Improvement Research and Education Center (S-SPIRE), Department of Surgery, Stanford University School of Medicine, Palo Alto, CA.
Article Synopsis
- - The study investigates how well statistical methods are used in research examining racial and ethnic disparities in surgical care from 2021 to 2022, focusing on if they adequately adjust for variables that could influence outcomes.
- - Out of 224 papers reviewed, a significant portion (63.2% of single-institution and 60.8% of multisite studies) adjusted for social determinants of health, though only a small fraction considered the clustering of patients within hospitals or the effects of different providers.
- - The findings indicate that many studies fail to meet essential statistical criteria, suggesting that improving publication guidelines could enhance the accuracy of these studies' estimates of disparities in surgical access and outcomes.
Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma.
APL Bioeng
June 2024
Department of Pharmacology, Physiology & Biophysics, Boston University Chobian & Avedisian School of Medicine, Boston, Massachusetts 02118, USA.
Previous lung-on-chip devices have facilitated significant advances in our understanding of lung biology and pathology. Here, we describe a novel lung-on-a-chip model in which human induced pluripotent stem cell-derived alveolar epithelial type II cells (iAT2s) form polarized duct-like lumens alongside engineered perfused vessels lined with human umbilical vein endothelium, all within a 3D, physiologically relevant microenvironment. Using this model, we investigated the morphologic and signaling consequences of the KRAS mutation, a commonly identified oncogene in human lung adenocarcinoma (LUAD).
View Article and Find Full Text PDFRacial and Ethnic and Rural Variations in Access to Primary Care for Veterans Following the MISSION Act.
JAMA Health Forum
June 2024
VA Boston Healthcare System, Center for Healthcare Organization, Implementation and Research, Boston, Massachusetts.
Importance: The 2018 Veterans Affairs Maintaining Internal Systems and Strengthening Integrated Outside Networks (VA MISSION) Act was implemented to increase timely access to care by expanding veterans' opportunities to receive Veterans Affairs (VA)-purchased care in the community (community care [CC]). Because health equity is a major VA priority, it is important to know whether Black and Hispanic veterans compared with White veterans experienced equitable access to primary care within the VA MISSION Act.
Objective: To examine whether utilization of and wait times for primary care differed between Black and Hispanic veterans compared with White veterans in rural and urban areas after the implementation of the VA MISSION Act.
Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group.
Pulm Circ
October 2023
Division of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah USA.
Article Synopsis
- The manuscript focuses on real-world evidence (RWE) in pulmonary hypertension (PH), involving experts from the Pulmonary Vascular Research Institute.
- The goal is to enhance the research community's understanding of RWE to advance clinical research and improve patient care for those with PH.
- The text reviews sources of real-world data (RWD), highlights challenges and opportunities in using RWD for PH research, and identifies necessary resources to generate impactful RWE for the global PH community.