Discovery of a new inhibitor for YTH domain-containing mA RNA readers.

-methyladenosine (mA) is an abundant modification in mammalian mRNAs and plays important regulatory roles in gene expression, primarily mediated through specific recognition by "reader" proteins. YTH family proteins are one major family of known mA readers, which specifically recognize mA-modified transcripts the YTH domains. Despite the significant relevance of YTH-mA recognition in biology and diseases, few small molecule inhibitors are available for specifically perturbing this interaction.

Pregnancy-specific dietary guidelines for Americans are not met: Findings from a pilot study.

Objective: To assess maternal dietary intake during pregnancy and adherence to the 2020-2025 pregnancy-specific Dietary Guidelines for Americans (DGA).

Methods: This was a retrospective observational study. The study population consisted of women who gave birth to term infants (>37 weeks of gestation).

The role of ion solvation in lithium mediated nitrogen reduction.

Since its verification in 2019, there have been numerous high-profile papers reporting improved efficiency of lithium-mediated electrochemical nitrogen reduction to make ammonia. However, the literature lacks any coherent investigation systematically linking bulk electrolyte properties to electrochemical performance and Solid Electrolyte Interphase (SEI) properties. In this study, we discover that the salt concentration has a remarkable effect on electrolyte stability: at concentrations of 0.

Correction: The role of ion solvation in lithium mediated nitrogen reduction.

[This corrects the article DOI: 10.1039/D2TA07686A.].

Heparan sulfate glycomimetics iterative assembly of "clickable" disaccharides.

Heparan sulfate (HS) glycosaminoglycans are widely expressed on the mammalian cell surfaces and extracellular matrices and play important roles in a variety of cell functions. Studies on the structure-activity relationships of HS have long been hampered by the challenges in obtaining chemically defined HS structures with unique sulfation patterns. Here, we report a new approach to HS glycomimetics based on iterative assembly of clickable disaccharide building blocks that mimic the disaccharide repeating units of native HS.

A outer-sphere oxidative addition: the reaction mechanism in Pd/Senphos-catalyzed carboboration of 1,3-enynes.

We report a combined experimental and computational study of Pd/Senphos-catalyzed carboboration of 1,3-enynes utilizing DFT calculations, P NMR study, kinetic study, Hammett analysis and Arrhenius/Eyring analysis. Our mechanistic study provides evidence against the conventional inner-sphere β-migratory insertion mechanism. Instead, a outer-sphere oxidative addition mechanism featuring a Pd-π-allyl intermediate followed by coordination-assisted rearrangements is consistent with all the experimental observations.

A peptide-crosslinking approach identifies HSPA8 and PFKL as selective interactors of an actin-derived peptide containing reduced and oxidized methionine.

The oxidation of methionine to methionine sulfoxide occurs under conditions of cellular oxidative stress, and modulates the function of a diverse array of proteins. Enzymatic systems that install and reverse the methionine sulfoxide modifications have been characterized, however, little is known about potential readers of this oxidative modification. Here, we apply a peptide-crosslinking approach to identify proteins that are able to differentially interact with reduced and oxidized methionine-containing peptides.

N-Terminal cysteine mediated backbone-side chain cyclization for chemically enhanced phage display.

Phage display, an ingenious invention for evaluating peptide libraries, has been limited to natural peptides that are ribosomally assembled with proteinogenic amino acids. Recently, there has been growing interest in chemically modifying phage libraries to create nonnatural cyclic and multicyclic peptides, which are appealing for use as inhibitors of protein-protein interactions. While earlier reports largely focused on side-chain side-chain cyclization, we report herein a novel strategy for creating backbone-side chain cyclized peptide libraries on phage.

A comparison of hydrogen release kinetics from 5- and 6-membered 1,2-BN-cycloalkanes.

The reaction order and Arrhenius activation parameters for spontaneous hydrogen release from cyclic amine boranes, , BN-cycloalkanes, were determined for 1,2-BN-cyclohexane (1) and 3-methyl-1,2-BN-cyclopentane (2) in tetraglyme. Computational analysis identified a mechanism involving catalytic substrate activation by a ring-opened form of 1 or 2 as being consistent with experimental observations.

Identifying cysteine residues susceptible to oxidation by photoactivatable atomic oxygen precursors using a proteome-wide analysis.

The reactivity profile of atomic oxygen [O(P)] in the condensed phase has shown a preference for the thiol group of cysteines. In this work, water-soluble O(P)-precursors were synthesized by adding aromatic burdens and water-soluble sulphonic acid groups to the core structure of dibenzothiophene--oxide (DBTO) to study O(P) reactivity in cell lysates and live cells. The photodeoxygenation of these compounds was investigated using common intermediates, which revealed that an increase in aromatic burdens to the DBTO core structure decreases the total oxidation yield due to competitive photodeoxygenation mechanisms.

"The greedy I that gives"-The paradox of egocentrism and altruism: Terror management and system justification perspectives on the interrelationship between mortality salience and charitable donations amid the COVID-19 pandemic.

Why do people give and help others in face of their own mortality salience? The existential struggle with the awareness of death impacts the gamut of human cognition, emotion, and behavior. This multi-method research (∑ = 1,219) explains the psychosocial impact of COVID-19-related mortality salience on altruism. Drawing from terror management theory, two studies tested death-thought accessibility, mortality salience, and anxiety buffer hypotheses.

Wavy graphene sheets from electrochemical sewing of corannulene.

The presence of non-hexagonal rings in the honeycomb carbon arrangement of graphene produces rippled graphene layers with valuable chemical and physical properties. In principle, a bottom-up approach to introducing distortion from planarity of a graphene sheet can be achieved by careful insertion of curved polyaromatic hydrocarbons during the growth of the lattice. Corannulene, the archetype of such non-planar polyaromatic hydrocarbons, can act as an ideal wrinkling motif in 2D carbon nanostructures.

Leveraging genomics to understand threats to migratory birds.

Understanding how risk factors affect populations across their annual cycle is a major challenge for conserving migratory birds. For example, disease outbreaks may happen on the breeding grounds, the wintering grounds, or during migration and are expected to accelerate under climate change. The ability to identify the geographic origins of impacted individuals, especially outside of breeding areas, might make it possible to predict demographic trends and inform conservation decision-making.

Promoting Ge Alloying Reaction via Heterostructure Engineering for High Efficient and Ultra-Stable Sodium-Ion Storage.

Germanium (Ge)-based materials have been considered as potential anode materials for sodium-ion batteries owing to their high theoretical specific capacity. However, the poor conductivity and Na diffusivity of Ge-based materials result in retardant ion/electron transportation and insufficient sodium storage efficiency, leading to sluggish reaction kinetics. To intrinsically maximize the sodium storage capability of Ge, the nitrogen doped carbon-coated CuGe/Ge heterostructure material (CuGe/Ge@N-C) is developed for enhanced sodium storage.

A Spatially Variable Time Series of Sea Level Change Due to Artificial Water Impoundment.

The artificial impoundment of water behind dams causes global mean sea level (GMSL) to fall as reservoirs fill but also generates a local rise in sea level due to the increased mass in the reservoir and the crustal deformation this mass induces. To estimate spatiotemporal fluctuations in sea level due to water impoundment, we use a historical data set that includes 6,329 reservoirs completed between 1900 and 2011, as well as projections of 3,565 reservoirs that are expected to be completed by 2040. The GMSL change associated with the historical data (-0.

Modified Nanopillar Arrays for Highly Stable and Efficient Photoelectrochemical Water Splitting.

Atomically modified graphitic carbon nitride quantum dots (QDs), characterized by strongly increased reactivity and stability, are developed. These are deposited on arrays of TiO nanopillars used as a photoanode for the photoelectrochemical water splitting. This photoanode shows excellent stability, with 111 h of continuous work without any performance loss, which outperforms the best-reported results by a factor of 10.

Artificial Mushroom Sponge Structure for Highly Efficient and Inexpensive Cold-Water Steam Generation.

A bioinspired structure of an artificial mushroom, made of the common polyvinyl alcohol sponge coated with charcoal, is fabricated, with high efficiency in generating cold water steam of ≈73% under 1 sun illumination, due to very high light absorption, efficient water supply, and low heat loss. In addition, the structure is very inexpensive, and thus ideal for applications in portable cold (boil-free) steam generators for water purification and desalination.

Social science perspectives on drivers of and responses to global climate change.

This article provides a review of recent anthropological, archeological, geographical, and sociological research on anthropogenic drivers of climate change, with a particular focus on drivers of carbon emissions, mitigation and adaptation. The four disciplines emphasize cultural, economic, geographic, historical, political, and social-structural factors to be important drivers of and responses to climate change. Each of these disciplines has unique perspectives and makes noteworthy contributions to our shared understanding of anthropogenic drivers, but they also complement one another and contribute to integrated, multidisciplinary frameworks.

Microphysical explanation of the RH-dependent water affinity of biogenic organic aerosol and its importance for climate.

A large fraction of atmospheric organic aerosol (OA) originates from natural emissions that are oxidized in the atmosphere to form secondary organic aerosol (SOA). Isoprene (IP) and monoterpenes (MT) are the most important precursors of SOA originating from forests. The climate impacts from OA are currently estimated through parameterizations of water uptake that drastically simplify the complexity of OA.