6 results match your criteria: "Bordeaux University and Bordeaux Hospital[Affiliation]"

Urinary incontinence in systemic sclerosis: a prospective multicentre cohort study.

Rheumatol Int

December 2022

Department of Pathology and Immunology, University Medical Centre, Geneva University, Rue Michel-Servet 1, CH-1211, Geneva, Switzerland.

Investigate the natural history of urinary incontinence (UI) in systemic sclerosis (SSc) and assess its impact on quality of life (QoL). A longitudinal, international observational study followed 189 patients with SSc for a median duration of 5 years (IQR: 4.8-5.

View Article and Find Full Text PDF
Article Synopsis
  • The study highlights that HIV-infected individuals face accelerated aging, as shown by a higher prevalence of age-related health issues compared to the general population.
  • The researchers used various biomarkers to analyze immune activation and inflammation in 828 patients with controlled HIV, finding that certain immune scores were linked to the presence of multiple health conditions and the risk of developing new ones.
  • Importantly, higher cellular CIADIS scores were associated with a greater risk of age-related comorbidities and TNFRI levels correlated with increased mortality over three years.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to investigate how common lower urinary tract symptoms (LUTS) are in patients with systemic sclerosis (SSc), identify specific risk factors, and evaluate their effect on quality of life (QoL).
  • Out of 334 patients surveyed, 96% reported LUTS, with storage symptoms being the most common, followed by voiding and post-micturition symptoms.
  • The results showed that factors like higher disability index scores and digestive symptoms significantly increased the chances of experiencing severe LUTS, which in turn negatively impacted the patients' quality of life.
View Article and Find Full Text PDF

Objectives: The aim of this study was to explore the association between urinary incontinence (UI) and the main clinical and serological subsets of SSc, to assess risk factors for UI and its impact on quality of life (QoL).

Methods: UI and QoL were assessed through self-administered questionnaires in 334 patients with SSc from five European tertiary centres. Logistic regressions were performed to test the association between clinical forms, serological status and UI and to adjust for confounders.

View Article and Find Full Text PDF

Activation, senescence and inflammation markers in HIV patients: association with renal function.

AIDS

May 2017

aUniversity Bordeaux, ISPED, Inserm, Bordeaux Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401 bCNRS-UMR 5164 Immuno ConcEpT, Bordeaux University and Bordeaux Hospital cCHU de Bordeaux, Service de médecine interne et immunologie clinique dCHU de Bordeaux, Service de Maladies infectieuses et Tropicales eCHU de Bordeaux, Service de néphrologie, transplantation et dialyse fCHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, University Bordeaux, Bordeaux gCHU de Bordeaux, Service de Médecine Interne, Hôpital Haut-Lévêque, Pessac hCHU de Bordeaux, Pôle de santé publique iCHU de Bordeaux, service de Médecine Interne et Maladies Infectieuses, Bordeaux, France. *Alexandra Ozanne, Pierre Duffau, Linda Wittkop and Isabelle Pellegrin contributed equally to the article.

Objectives: To assess the association among immune activation, immune senescence, inflammation biomarkers and renal function measured by estimated glomerular filtration rate (eGFR) at inclusion and its evolution over a 3-year follow-up in HIV-infected patients with undetectable viral load.

Design: The Chronic Immune Activation and Senescence (CIADIS) substudy consecutively included patients between October 2011 and May 2013 enrolled in the ANRS CO3 Aquitaine observational cohort.

Methods: Biomarkers of T-cell activation, differentiation and senescence were summarized in a cellular-CIADIS weighted score and inflammation biomarkers in a soluble-CIADIS weighted score using principal component analysis.

View Article and Find Full Text PDF

Objective: To investigate the relationship between vascular damage and fibrosis in systemic sclerosis (SSc) by testing the hypothesis that platelets contribute to skin fibrosis via the activation of human dermal microvascular endothelial cells (HDMECs) and subsequent production of profibrotic mediators.

Methods: A total of 203 SSc patients and 30 healthy donors were prospectively enrolled between 2012 and 2015 at the University Hospital of Bordeaux. Immunohistochemistry and immunofluorescence analyses were performed on skin biopsy sections from 18 SSc patients and 5 healthy donors.

View Article and Find Full Text PDF