Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor.

Priming of polymorphonuclear leukocytes (PMNs) enhances their adhesion to endothelium, the release of their granule content and their production of reactive oxygen species. These effects are etiological in transfusion related acute lung injury (TRALI) and many clinically important mediators of TRALI prime PMNs. A priming activity that develops over time in stored blood products has been shown to be due to the accumulation of lysophospatidylcholines (lyso-PCs) and has been found to be related clinically to TRALI.

Platelets and neutrophils from healthy term neonates exhibit increased levels of immunoglobulins.

Immune-mediated thrombocytopenia and neutropenia are not uncommon problems in the newborn period. Such cytopenias have been associated with increased levels of IgG, IgM, or both, in the serum, documented by indirect assay, and/or on the cell surface, documented by direct assay, and decreased cell survival. However, interpretation of measurement of platelet- or neutrophil-associated antibodies is problematic due to the lack of data from healthy neonates.

Transfusion-associated transmission of human T-lymphotropic virus types I and II: experience of a regional blood center.

During a 22-month period, 78,000 blood donors were screened for human T-lymphotropic virus types I and II (HTLV-I/II) at Belle Bonfils Memorial Blood Center (Denver, Colorado). Positive donors and the living recipients of their previously donated blood components were evaluated for risk factors and symptoms related to HTLV-I infection, were screened by enzyme immunoassay, confirmed by Western blot for HTLV-I/II, and subsequently tested by polymerase chain reaction and peptide enzyme immunoassay to distinguish between HTLV-I and -II infection. Six seropositive blood donors (0.