Diagnosis and management of residual atrial septal defect after surgical failure: A case series.

Residual defect after surgical closure of atrial septal defect is extremely uncommon. This communication reports four cases encountered in a tertiary care center during the last three decades. Clinical diagnosis was challenging, and the diverse presentations included acute ischemic stroke, cyanosis, and right ventricular volume overload.

Para-Bombay blood group: Report of a rare blood group.

Para-Bombay blood group is a rare blood group typically characterized by the absence of H antigens on red blood cell and the presence of ABH substances on secretion. It can be easily missed and often mistaken as blood group O without extended testing. Detection is important as it significantly affect transfusion management.

Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India.

This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross-sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines.

Loss of correlated proteasomal subunit expression selectively promotes the 20S state which underlies luminal breast tumorigenicity.

Why cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. While mis-regulated ubiquitination is a contributing factor, here we show that a structurally-perturbed and sub-optimally functioning proteasome is at the core of altered proteostasis in tumors. By integrating the gene coexpression signatures of proteasomal subunits in breast cancer (BrCa) patient tissues with the atomistic details of 26S holocomplex, we find that the transcriptional deregulation induced-stoichiometric imbalances perpetuate with disease severity.

Atraumatic Bilateral Transcervical Femoral Neck Fractures in an Elderly Epileptic Patient: A Case Report.

Introduction: The occurrence of non-traumatic bilateral femoral neck fractures is exceedingly rare, and their manifestation subsequent to an epileptic attack is an uncommon entity with very few cases reported globally.

Case Report: We present the positive outcome of a 68-year-old man who underwent staged bilateral constrained total hip arthroplasty following a fracture resulting from a generalized seizure. This unconventional decision was justified based on several factors, including fracture pattern, bone quality, seizure history, and advanced tribology.

Voices of Nanomedicine: Blueprint Guidelines for Collaboration in Addressing Global Unmet Medical Needs.

The "" under this Perspective underline the importance of interdisciplinary collaboration and partnerships across several disciplines, such as medical science and technology, medicine, bioengineering, and computational approaches, in bridging the gap between research, manufacturing, and clinical applications. Effective communication is key to bridging team gaps, enhancing trust, and resolving conflicts, thereby fostering teamwork and individual growth toward shared goals. Drawing from the success of the COVID-19 vaccine development, we advocate the application of similar collaborative models in other complex health areas such as nanomedicine and biomedical engineering.

Rare Primary Pericardial Mesothelioma on an [18F]FDG PET/CT Scan and Its Postchemotherapy Response Evaluation.

Primary pericardial mesothelioma is a highly aggressive and rare neoplasm that arises from the pericardial mesothelial cell and has a poor prognosis. The diagnosis is usually established by histological and immunohistochemical studies. Malignant mesothelioma most frequently occurs from the pleura (90%), less frequently from the peritoneum and pericardium (6%-10%), and very rarely from the tunica vaginalis in the testis.

Comparative analysis of brain volumetric measurements between contrast-enhanced and non-contrast MRI images.

Background: Clinical brain MRI scans, including contrast-enhanced (CE-MR) images, represent an underutilized resource for neuroscience research due to technical heterogeneity.

Purpose: To evaluate the reliability of morphometric measurements from CE-MR scans compared to non-contrast MR (NC-MR) scans in normal individuals.

Methods: T1-weighted CE-MR and NC-MR scans from 59 normal participants (aged 21-73 years) were compared using CAT12 and SynthSeg+ segmentation tools.

Optimising deformity correction: a retrospective comparative analysis of two techniques in high magnitude curves in adolescent idiopathic scoliosis.

Study Design: A retrospective comparative study.

Purpose: To validate the hypothesis that a combination of multilevel Ponte osteotomy (PO) with intraoperative traction (IOT) results in a better correction than IOT alone in high-magnitude curves in adolescent idiopathic scoliosis (AIS) and does not possess an attributable risk of neurological injury.

Overview Of Literature: On a comprehensive review of the literature, the choice of technique adopted for curves between 65° and 100° remains controversial with no major consensus favoring one technique over the other.

Challenges in the Management of Hemorrhagic Shock in Patients with Bombay Blood Group in the ICU: What the H?

Bhosale SJ, Joshi M, Dhakane P, Ojha S, Kulkarni AP. Challenges in the Management of Hemorrhagic Shock in Patients with Bombay Blood Group in the ICU: What the H? Indian J Crit Care Med 2024;28(12):1185-1186.

Dr Pranjivandas Manekchand Mehta MD, MS, FCPS 1889-1981 and (1949).

Pranjivandas Manekchand Mehta (1889-1981), MD, MS, FCPS, also known as Dr P M Mehta, was an Indian physician and surgeon in Bombay, who then became the personal physician of the Maharajah Jamsaheb of the former Princely State of Nawanagar, Gujarat, British India. The Jamsaheb appointed Mehta as the Chief Medical Officer of Nawanagar, and with the guidance of the French radiologist, Jean Saidman, oversaw the construction of the first solarium in India. Mehta persuaded the Jamsaheb to fund an institution dedicated to Ayurvedic studies, named the Shri Gulabkunverba Ayurvedic Society, the precursor to the first Ayurveda college in India, and he became the Director of the Central Institute of Research on Indigenous Systems, which later came under the umbrella of the Institute of Teaching and Research in Ayurveda, Jamnagar.

Obesity and Sympathetic Overactivity in Young Individuals With Hypertension: Clinical Perspective of Indian Healthcare Providers.

Introduction: To understand the current clinical practices followed by healthcare professionals (HCPs) among populations with hypertension and obesity with sympathetic overactivity and develop strategies to improve the management of hypertension.

Methods: A standard questionnaire was formulated based on high sympathetic overactivity and/or obesity in young patients with hypertension to gather information on the perception and practices of HCPs toward the management of young patients with hypertension who have high sympathetic overactivity and/or obesity. HCPs throughout India were selected.

Clinical Experience of Dissolvable Calcium Sulfate (Stimulan) Carrier for Antibiotic Delivery in Orthopedic Surgery: A Study of 143 Patients.

Prosthetic bone and joint infections are difficult to treat with varying levels of success with standard therapy. Synthetic calcium sulfate carrier, to which specific antibiotics can be added, can be utilized as an alternative drug delivery system in these cases. We have reviewed clinical outcomes using commercially available pure synthetic calcium sulfate dissolvable beads (Stimulan) loaded with antibiotics in 143 patients undergoing orthopedic surgery for prevention and treatment of joint infection.

Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study.

Background And Aim: Chronic lower back pain (CLBP) is a major condition that leads to disability and reduced quality of life (QoL). This randomised, double-blind, placebo-controlled clinical study evaluated the efficacy and safety of a novel Boswellia serrata and Curcuma longa combination (CL20192) for the treatment of CLBP.

Material And Methods: Participants with CLBP were randomised to receive either a 300 mg CL20192 capsule (n = 45) or placebo capsule (n = 45) once daily for 90 days.

A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study.

Background: The trend over time and across different geographical areas of outcomes and management with noninvasive ventilation or invasive mechanical ventilation in patients admitted for acute exacerbations of chronic obstructive pulmonary disease and treated with ventilatory support is unknown. The purpose of this study was to describe outcomes and identify variables associated with survival for patients admitted to an intensive care unit (ICU) with acute exacerbation of chronic obstructive pulmonary disease [aeCOPD] who received noninvasive or invasive mechanical ventilation worldwide.

Methods: Retrospective, multi-national, and multicenter studies, including four observational cohort studies, were carried out in 1998, 2004, 2010, and 2016 for the VENTILAGROUP following the same methodology.

Heterogeneity-provoked pulse generation in coupled excitable elements.

Pulse generation in a spatially extended system is studied numerically. Using an array of coupled excitable oscillators, pulse generation is achieved by introducing a parametric heterogeneity between the two partitions of the array. The profile of the propagating pulses can be regulated using the parameter mismatch between these two partitions.

π-HuB: the proteomic navigator of the human body.

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies.

Health Systems for Rehabilitation - Critical Appraisal of the National Programme for Stroke in India.

The organized provision of health services in India has been envisioned since 1946 by the recommendations from the Bhore committee. However, the policy and program strategies for the provision of good quality health care still lack effectiveness. Access to rehabilitation services for persons with disabilities continues to be a significant public health problem in India.

Reclassifying cT4b buccal mucosa/gingivobuccal complex cancers: do we need to change?

T4b carcinomas are termed as very locally advanced carcinomas of the oral cavity and are deemed borderline resectable or unresectable. The role of surgery for these patients is not well defined. We therefore aimed to relook at the role of surgery for cT4b carcinoma of the oral cavity.

Complications Following Microvascular Decompression (MVD) for Trigeminal Neuralgia (TN).

This article descibes the surgical management of classic trigeminal neuralgia via microvascular decompression of the neuro-vascular conflict zone. This treatment has been proven to be higly effective with an immediate relief of debilitating symptoms and a durable response. The article reports on cases with associated complications and their avoidance.

Postoperative CSF Rhinorrhoea.

Cerebrospinal fluid (CSF) rhinorrhoea is a well known complication following skull base surgery. Identifying the site of leak is the most important determinant for the appropriate approach in the further management of the case. Either transcranial or transnasal approaches may be used, alone or in combination, as deemed appropriate.

Preventing Wrong-Level Spine Surgery.

Importance: Wrong-level spine surgery (WLSS), a medical error in which a surgeon operates at an unintended vertebral level, is considered a "never event." However, it continues to be a problem in spine surgery today despite the implementation of preventive measures such as the Universal Protocol. The consequences of this event are severe for both the afflicted patient and the treating physician and may result not only in physical harm but also in costly medicolegal proceedings.