Combined Effect of Ambient Temperature and Relative Humidity on Skin Aging Phenotypes in the Era of Climate Change: Results From an Indian Cohort Study.

There is no doubt that global warming, with its extreme heat events, is having an increasing impact on human health. Heat is not independent of ambient temperature but acts synergistically with relative humidity (RH) to increase the risk of several diseases, such as cardiovascular and pulmonary diseases. Although the skin is the organ in direct contact with the environment, it is currently unknown whether skin health is similarly affected.

Surgical Planning and 3D-Printed Mesh Implant for Effective Bone Gap Management: A Case Report.

Introduction: Critical-size bone defects in distal tibial open wounds pose a formidable challenge, requiring interventions that can address osseous reconstruction with less number of surgeries. Current treatment modalities may fall short in achieving optimal outcomes, with respect to early weight bearing due to the inability of the graft to sustain weight, graft-related infections, non-union in large defects, donor site morbidity, and non-availability of bone grafts due to earlier harvest. This case report explores the potential application of a 3D-printed mesh implant to this complex clinical scenario.

Timing matters: investigating the interplay of presentation duration and congruency in approximate number processing.

The approximate number system (ANS) is an innate number sense ability; it plays a pivotal role in the development of symbolic number ability. Despite studies using a wide range of presentation durations of stimuli to investigate the approximate number processing, limited literature has systematically explored its impact on approximate number processing. Further, if increasing presentation duration leads to improved accuracy, it remains unclear whether this improvement will be driven by better performance in both congruent and incongruent conditions or only in one condition.

Percolation transitions in a binary mixture of active Brownian particles with different softness.

Homogeneous active Brownian particle (ABP) systems with purely repulsive interactions are considered to exhibit a simple phase behavior, but various physical attributes of active entities can lead to variation in the collective dynamics. Recent studies have shown that even homogeneous ABPs exhibit complex behavior due to an interplay between particle softness and motility. However, the heterogeneity in the composition of ABPs has not been explored yet.

Homobimetallic Ruthenium(II) Complexes Catalysed Selective Transfer Hydrogenation of Aldehydes in Water.

Herein we report chemoselective transfer hydrogenation (TH) of aldehydes in aqueous medium using a series of homobimetallic Ru(II) catalysts. Two homobimetallic complexes (Ru1 and Ru3) and one monometallic complex (Ru2) have been employed in the catalytic reduction of aldehydes. Bimetallic complex [(p-cymene)(RuCl)L] (Ru3) is obtained from the reaction of Schiff base ligand 2,2'-((1E,1'E)-((3,3',5,5'-tetraisopropyl-[1,1'-biphenyl]-4,4'diyl)bis(azaneylylidene))bis(methaneylylidene))bis(4-bromophenol) (HL) and characterized by various spectroscopic and analytical techniques.

Expanding the Scope of a One-Pot Double Displacement Protocol to Access the All-Rare-Sugar-Containing Trisaccharide Unit of OX1.

Herein, we have explored a one-pot bis-triflation and regioselective displacement protocol with d-fucose 2,4-diol to access various rare 6-deoxy amino d-sugars. This strategy enabled the first total synthesis of the trisaccharide unit of OX1 strain containing d-perosamine and d-tomosamine. Installation of a 1,2- linkage and late-stage -formylation are the key challenges in the total synthesis, which was accomplished via the longest linear sequence of 21 steps with 1.

Deciphering the spectroscopic and thermodynamic aspects of binding of biologically important antioxidants with the alkali induced state of human serum albumin.

Protein-ligand interactions are crucial for developing and identifying novel therapeutic targets. In this study, we investigate the interaction of the alkali induced state of human serum albumin (pH 11.2) with three hydroxycinnamic acid derivatives (HCDs), ferulic acid (FA), sinapic acid (SA) and -coumaric acid, which are biologically important antioxidants, and compare the outcomes with the results obtained at physiological pH (7.

[Genetic analysis of a blood donor with combined FUT1 and ABO dual blood group gene variants resulting in para-Bombay and A2 subtype blood types and a literature review].

Objective: To investigate the serological and molecular genetic characteristics of a voluntary blood donor with combined FUT1 and ABO blood group gene variants causing para-Bombay and A2 subtype, and to review relevant literature on para-Bombay blood types carrying alleles such as FUT101W.37 and FUT101W.23.

Photothermally Active Quantum Dots in Cancer Imaging and Therapeutics: Nanotheranostics Perspective.

Cancer is becoming a global threat, as the cancerous cells manipulate themselves frequently, resulting in mutants and more abnormalities. Early-stage and real-time detection of cancer biomarkers can provide insight into designing cost-effective diagnostic and therapeutic modalities. Nanoparticle and quantum dot (QD)-based approaches have been recognized as clinically relevant methods to detect disease biomarkers at the molecular level.

Impact of 5-Flurouracil loaded chitosan nanoparticle on A375 and A431 cell line for the therapy of skin cancer.

Skin cancer is an uncontrolled proliferation of abnormal skin cells that is usually caused by damaging UV radiation. Skin cancer is classified into two types: non-melanoma skin cancer and melanoma skin cancer. The entire studies focus on cytotoxic effect of prepared 5-Flurouracil loaded chitosan nanoparticle using A375 and A431 skin cancer cell line.

Bridging gap in treatment of polycystic ovarian syndrome through drug repurposing: what we achieved and where we are?

Polycystic ovarian syndrome (PCOS) is one of the chief causes of infertility in women of reproductive age. Several drugs belonging to the oral contraceptive class have been approved for the treatment of PCOS. Nonetheless, the capability to target only a few symptoms of PCOS and fatal side effects are key hurdles to their use.

An Iron-Based Fluorophosphate Cathode Material for K-Ion Batteries.

The development of a tavorite structured K- transition metal (T)- fluorophosphate, having earth-abundant Fe as the only T, crystallizing in the orthorhombic crystal system and facilitating stable-cum-reversible electrochemical K-extraction/insertion, has been reported here. Synthesized using low-cost precursors, KFePOF has also been found to be air-stable. Detailed information pertaining to the bonding/structure, including lattice site occupancy, have been obtained via diffraction, Raman spectroscopy and FTIR, with XPS, Mössbauer and ESR revealing the oxidation states and nature of Fe in the as-synthesized condition and upon being subjected to electrochemical potassiation/depotassiation.

Iron-Mediated Segment Coupling of Alkenols with Acceptors via C-C Radical Translocation and Remote Oxidative 1,5/6-Hydrogen Atom Transfer.

Iron-mediated segment coupling followed by oxidative 1,5/6-hydrogen atom transfer (HAT) for synthesis of ε-oxo alkene derivatives is developed. This transformation involved translocation of the radical from H-to-C-to-C-to-C followed by the oxidation under MHAT conditions providing rapid access to 1,6/1,7-keto functionalized esters/ketone/sulfones/phosphonates/arenes. The different outcomes of coupling with acceptors could be explained by bond dissociation energies (BDEs), and mechanistic insights were gained through control experiments, including deuterium labeling studies.

Synthesis of Acenaphthene Fused Dithiaporphyrin(3.1.1.1)s and N-Fused Triphyrin(3.1.1)s in One-Pot Condensation.

Two different types of novel nonaromatic acenaphthene fused macrocycles such as acenaphthene fused dithiaporphyrin(3.1.1.

Protective effects of and extract on oxaliplatin-induced neuropathy via modulation of NF-κB signaling.

Oxaliplatin is a third-generation anticancer agent with better efficacy, lower toxicity, and a broad spectrum of antineoplastic activity. Its use is frequently associated with chronic oxaliplatin-induced neuropathy (OIN), a cumulative phenomenon manifesting as loss of sensation, paresthesia, dysesthesia, and irresolvable fluctuations in proprioception that greatly affect the patients' quality of life. The inevitable nature and high incidence of OIN, along with the absence of efficacious preventive agents, necessitate the development of effective and reliable protective options for limiting OIN while maintaining anticancer activity.

Inkjet-Printed FASnPbI-Based Perovskite Solar Cells.

Metal halide perovskite solar cells (PSCs) have gained significant attention in thin-film photovoltaic research for their high power conversion efficiency (PCE) and facile fabrication processes. This study presents the use of inkjet printing to fabricate thin films of combinatorial mixed formamidinium tin-lead perovskites and evaluates their layer quality and device performance. Our findings demonstrate that incorporating Pb up to 50% into FASnI films enhances lattice stability.

Expert Opinion on the Role of Sacubitril/Valsartan in the Management of Hypertension in India.

Hypertension, a key modifiable risk factor for cardiovascular diseases (CVD), significantly contributes to premature death and morbidity worldwide. Despite stabilization in age-adjusted global prevalence, the absolute number of hypertensive individuals doubled from 2000 to 2010, largely due to increases in low- and middle-income countries. In 2021, only 21% of hypertensive individuals globally had effective blood pressure (BP) control.

Sonodynamic Cancer Therapy by Mn(I)-tricarbonyl Complexes via Ultrasound-triggered CO Release and ROS Generation.

A novel ferrocene conjugated Mn(I)-tricarbonyl complex viz [Mn(Fc-tpy)(CO)Br] (Mn2) where, Fc-tpy=4'-ferrocenyl-2,2':6',2''-terpyridine was synthesized and fully characterized along with its non-ferrocene analog [Mn(Ph-tpy)(CO)Br] Ph-tpy=4'-phenyl-2,2':6',2''-terpyridine (Mn1) for ultrasound (US) activated anticancer applications. The X-ray structure of Mn2 confirmed its distorted octahedral geometry. Mn1 and Mn2, for the first time, showed US-triggered release of CO and ROS generation (O and OH) in an aqueous solution from any Mn(I)-tricarbonyl complexes, indicating its potential for synergetic CO gas therapy and sonodynamic therapy.

Synergy of Nanocrystallinity, Temperature, and "the Third Element Effect" for Uncommon Oxidation Resistance of Fe-Cr-Al Alloys.

Nanocrystalline structure, oxidation temperature, and "The Third Element Effect" are among the factors that can profoundly govern the characteristics of the oxide scales that develop on oxidation-resistant alloys, thereby, their synergistic effect can considerably influence alloys' oxidation kinetics. As a result of the synergy, certain iron-chromium-aluminium (Fe-Cr-Al) alloy showed superior oxidation resistance at 800 °C than at 700 °C (whereas oxidation resistance commonly decreases with the increase in temperature). The superior resistance at higher temperatures is considerably enhanced when the structure of the alloy is nanocrystalline vis-à-vis the common microcrystalline structure.

Tripartite Detection and Sensing of Toxic Heavy Metals Using a Copper-Based Porphyrin Metal-Organic Framework.

The detection of heavy metals in water sources is a critical concern for environmental preservation and public health. However, current electrochemical heavy metal sensors suffer from high sensing limits, cross-sensitivity, and poor selectivity. In this work, we present the possibility of an electrochemical sensor based on a copper (Cu) metal-organic framework for the detection of lead, cadmium, and mercury by replacing Cu metal nodes.

Microwave-Assisted Fabrication of Copper Oxide/N-Doped Carbon Nanocatalyst for Efficient Electrochemical CO Conversion to Liquid Fuels.

Electrochemical CO reduction reaction (CORR), which is driven by electricity generated from renewable energy sources, is a promising technology for sustainably producing carbon-based chemicals or fuels. Several CORR catalysts have been explored to date, among which copper-based electrocatalysts are the most widely known for electrochemical CORR and are extensively studied for their ability to generate an array of products. Their low selectivity, however, hinders their possibility of being used for practical purposes.

Efficacy of dairy protein and essential nutrient density in formulated food products for treating severe and moderate acute malnutrition at the community level: a narrative review.

Community-based management of acute malnutrition (CMAM) relies on a food-based approach. However, a comprehensive assessment of their nutrient composition and its impact on treatment outcomes is currently lacking in the extant literature. This narrative review summarises recent evidence on the efficacy of formulations that contain dairy protein and maintain the density of essential nutrients (type I and type II) in managing uncomplicated acute malnutrition at the community level.

Iodine(III)-Mediated Keto-oximation of -Alkynyl Hydroxylamines: A Route to 3-Acyl Isoxazolines and 1,2-Oxazines.

An intramolecular iodine(III)-mediated keto-oximation of -alkynyl hydroxylamines offers rapid and straightforward access to 3-acyl Δ-isoxazolines and 1,2-oxazines. This approach features mild, metal-free, and aerobic reaction conditions with good functional group tolerance. Moreover, the synthetic utility of this method is demonstrated by the synthesis of unique structural motifs such as isoxazolidine, 3-vinyl isoxazoline, and 2,5-diphenylpyrazine derivatives by the conversion of 3-acyl Δ-isoxazolines, thereby showcasing its efficiency and applicability in synthetic chemistry.

Insights into the Structure and Dynamics of Proteins from F Solution NMR Spectroscopy.

F NMR spectroscopy has recently witnessed a resurgence as an attractive analytical tool for the study of the structure and dynamics of biomolecules in vitro and in cells, despite reports of its applications in biomolecular NMR since the 1970s. The high gyromagnetic ratio, large chemical shift dispersion, and complete absence of the spin 1/2 F nucleus from biomolecules results in background-free, high-resolution F NMR spectra. The introduction of F probes in a few selected locations in biomolecules reduces spectral crowding despite its increased line width in comparison to typical H NMR line widths and allows rapid site-specific measurements from simple 1D spectra alone.