2,513 results match your criteria: "Bogazici University[Affiliation]"

Wolbachia strengthens the match between pre-mating and early post-mating isolation in spider mites.

Evolution

October 2024

ISEM, Institut des Sciences de l'Évolution de Montpellier (ISEM), Université de Montpellier, CNRS, IRD, EPHE, Montpellier, France.

Endosymbiotic reproductive manipulators are widely studied as sources of post-zygotic isolation in arthropods, but their effect on pre-zygotic isolation between genetically differentiated populations has garnered less attention. We tested this using two partially isolated populations of the red and green colour forms of Tetranychus urticae, either uninfected or infected with different Wolbachia strains, one inducing cytoplasmic incompatibility and the other not. We first investigated male and female preferences, and found that, in absence of infection, females were not choosy, but all males preferred red-form females.

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Hydrogel-Integrated Heart-on-a-Chip Platform for Assessment of Myocardial Ischemia Markers.

ACS Omega

October 2024

Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.

Article Synopsis
  • The study developed a heart-on-a-chip platform using a single-channel PDMS microchip integrated with a hydrogel scaffold to support cardiomyocyte growth, mimicking human heart conditions.
  • This platform allows for better physiological simulations compared to previous microchip designs by employing 3D cell culture rather than 2D methods to create a more realistic cell microenvironment.
  • The heart-on-a-chip was tested under both normal and low-oxygen conditions to model myocardial ischemia, successfully detecting various biomarkers related to heart conditions, indicating its potential for future biological and clinical applications.
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Optimizing Solid Microneedle Design: A Comprehensive ML-Augmented DOE Approach.

ACS Meas Sci Au

October 2024

Department of Mechanical Engineering, Koç University, Sariyer, Istanbul 34450, Turkiye.

Microneedles (MNs), that is, a matrix of micrometer-scale needles, have diverse applications in drug delivery, skincare therapy, and health monitoring. MNs offer a minimally invasive alternative to hypodermic needles, characterized by rapid and painless procedures, cost-effective fabrication methods, and reduced tissue damage. This study explores four MN designs, cone-shaped, tapered cone-shaped, pyramidal with a square base, and pyramidal with a triangular-shaped base, and their optimization based on predefined criteria.

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A nematic phase, previously seen in the d=3 classical Heisenberg spin-glass system, occurs in the n-component cubic-spin spin-glass system, between the low-temperature spin-glass phase and the high-temperature disordered phase, for number of spin components n≥3, in spatial dimension d=3, thus constituting a liquid-crystal phase in a dirty (quenched-disordered) magnet. Furthermore, under application of a variety of uniform magnetic fields, a veritable plethora of phases is found. Under uniform magnetic fields, 17 different phases and two spin-glass phase diagram topologies (meaning the occurrences and relative positions of the many phases), qualitatively different from the conventional spin-glass phase diagram topology, are seen.

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The aim of this study is to investigate the reasons why international medical students choose Türkiye, which has one of the largest higher education capacities in Europe and is also among the top 10 most preferred countries in the world by international students, and their demographic and socioeconomic characteristics. The data of this cross-sectional study were collected through an online survey that included questions such as students' gender, age, ethnicity, monthly income, pre-school education, parental education level and professions, number of siblings, rural status of the region where they grew up, and reasons for choosing Türkiye. 482 students at various grade levels from 30 medical schools participated in the study.

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Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

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A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

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Article Synopsis
  • The study investigates the associated production of Higgs and W bosons, focusing on how the relative signs of the Higgs couplings to W and Z bosons impact the process.
  • Two specific searches were conducted using large amounts of collision data from the LHC to analyze different coupling scenarios: one for opposite-sign couplings and another for same-sign (standard model-like) couplings.
  • The results significantly exclude the opposite-sign coupling hypothesis and set a strict upper limit on the production rate of this process compared to standard model predictions.
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Unveiling the Potential of Protein-Based Sustainable Antibacterial Materials.

Probiotics Antimicrob Proteins

October 2024

Department of Chemistry, School of Natural Sciences (SNS), National University of Sciences & Technology (NUST), H-12, Islamabad, 44000, Pakistan.

The surge in bacterial growth and the escalating resistance against a multitude of antibiotic drugs have burgeoned into an alarming global threat, necessitating urgent and innovative interventions. In response to this peril, scientists have embarked on the development of advanced biocompatible antibacterial materials, aiming to counteract not only bacterial infections but also the pervasive issue of food spoilage resulting from microbial proliferation. Protein-based biopolymers and their meticulously engineered composites are at the forefront of this endeavor.

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The spatiotemporal pattern of surface displacements from large earthquakes provides crucial insights about the deformation of Earth's crust at various scales and the interactions among tectonic plates. However, the lack of extensive and large-scale geodetic networks near such seismic events hinders our thorough understanding of the large-scale crustal deformation resulting from earthquakes. Using Türkiye's extensive and continuous global navigation satellite system (GNSS) network during the moment magnitude 7.

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Textile-reinforced cementitious composites have great potential to offer novel design opportunities for thin-section structures thanks to their superior material capabilities. In this work, new cementitious composites with novel reinforcement configurations are developed, which have superior mechanical properties. The cementitious composites contain inclined through-the-thickness reinforcements, and their enhanced performance on thin-section material hardening under flexural loading is demonstrated.

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Following the 1st Conference of the Global Collaboration on Traumatic Stress, the consortium committed to systematically integrating sex and gender considerations in their endeavours, which aligns with the 's Gender Policy. This initiative is vital for understanding trauma's complex impacts, but also presents significant challenges in cross-cultural research. This letter, co-authored by researchers from across the globe, outlines these challenges and proposes mitigation strategies.

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Two novel ibuprofen cystamine salts (IBU-CYS 1 and IBU-CYS 2) are synthesized by coupling the anion of ibuprofen with cystamine dihydrochloride in 1 : 1 and 2 : 1 ratio to improve the solubility and bioavailability of ibuprofen. The salts are characterized by H NMR, FT-IR and UV-Vis spectroscopy, differential scanning calorimetry (DSC), thermogravimetry (TGA, DTA) and X-ray diffraction measurements. IBU-CYS 1 and IBU-CYS 2 show higher solubility (6.

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Article Synopsis
  • This study examined the effectiveness and reliability of study preregistration in psychology by analyzing 300 research studies to see how closely they followed their preregistered plans.
  • The findings revealed that many preregistrations lacked essential methodological details and frequently deviated from their original plans, which suggests that research biases are still possible.
  • To enhance the accuracy and utility of preregistration, the authors recommend improved training for researchers, more detailed registration templates, and better transparency in reporting deviations.
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Article Synopsis
  • The human immunodeficiency virus (HIV) poses a serious global health issue due to its ability to quickly mutate and develop resistance to drugs.
  • Recent research highlights the success of machine learning (ML) and deep learning (DL) in predicting which HIV strains will resist FDA-approved treatments, but expanding these models to consider both viral isolates and drug characteristics remains a challenge.
  • A new framework called the drug-isolate-fold change (DIF) model has been proposed, utilizing advanced modeling techniques and pre-trained graph neural networks to improve predictions on drug resistance, achieving notable accuracy and demonstrating the value of incorporating detailed molecular representations.
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Unveiling placental development in circadian rhythm-disrupted mice: A photo-acoustic imaging study on unstained tissue.

Placenta

December 2024

Department of Histology and Embryology, School of Medicine, Koc University, Rumelifeneri, Sariyer, Istanbul, 34450, Turkey; Koc University Research Center for Translational Medicine (KUTTAM), Koc University, Istanbul, Turkey. Electronic address:

Introduction: Circadian rhythm disruption has garnered significant attention for its adverse effects on human health, particularly in reproductive medicine and fetal well-being. Assessing pregnancy health often relies on diagnostic markers such as the labyrinth zone (LZ) proportion within the placenta. This study aimed to investigate the impact of disrupted circadian rhythms on placental health and fetal development using animal models.

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Herein, P2-type layered manganese and ruthenium oxide is synthesized as an outstanding intercalation cathode material for high-energy density Na-ion batteries (NIBs). P2-type sodium deficient transition metal oxide structure, NaMnRuO cathodes where x varied between 0.05 and 0.

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Generative language models on nucleotide sequences of human genes.

Sci Rep

September 2024

Department of Computer Engineering, Boğaziçi University, 34342, Istanbul, Turkey.

Language models, especially transformer-based ones, have achieved colossal success in natural language processing. To be precise, studies like BERT for natural language understanding and works like GPT-3 for natural language generation are very important. If we consider DNA sequences as a text written with an alphabet of four letters representing the nucleotides, they are similar in structure to natural languages.

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The target article argues that embodied cognitive neuroscience converges on a mechanistic approach to explanation. We argue that it does not. Even some of the article's for embodied cognitive neuroscience are explicitly non- or anti-mechanistic.

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Evaluating GPT and BERT models for protein-protein interaction identification in biomedical text.

Bioinform Adv

September 2024

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, United States.

Motivation: Detecting protein-protein interactions (PPIs) is crucial for understanding genetic mechanisms, disease pathogenesis, and drug design. As biomedical literature continues to grow rapidly, there is an increasing need for automated and accurate extraction of these interactions to facilitate scientific discovery. Pretrained language models, such as generative pretrained transformers and bidirectional encoder representations from transformers, have shown promising results in natural language processing tasks.

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Refractory organic matter (RfOM) is ubiquitous in aquatic environment and plays various roles in regulating the fate, transport, toxicity, and bioavailability of chemical species, such as metals, emerging organic contaminants, and nanomaterials. RfOM is mainly represented by humic acids (HA) as the acid insoluble fraction of organic matrix. Considering the complex and multicomponent characteristic of HA, a detailed study was designed to elucidate the fate of molecular size fractions (MSFrs) of humic under solar irradiation in the presence of polyaniline (PANI)-modified TiO composites.

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An early identification and subsequent management of cerebral small vessel disease (cSVD) grade 1 can delay progression into grades II and III. Machine learning algorithms have shown considerable promise in medical image interpretation automation. An experimental cross-sectional study aimed to develop an automated computer-aided diagnostic system based on AI (artificial intelligence) tools to detect grade 1-cSVD with improved accuracy.

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This Letter presents results from a combination of searches for Higgs boson pair production using 126-140  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.

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This Letter presents the first study of the energy dependence of diboson polarization fractions in WZ→ℓνℓ^{'}ℓ^{'}(ℓ,ℓ^{'}=e,μ) production. The dataset used corresponds to an integrated luminosity of 140  fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector. Two fiducial regions with an enhanced presence of events featuring two longitudinally polarized bosons are defined.

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The experiences of war and refugee status can alter intrafamily dynamics, with implications for family formation, including marriage. We use the nationally representative Syrian Migrant Sample of the 2018 Turkey Demographic Health Survey (TDHS-S) to conduct a duration analysis of marriage outcomes among Syrian refugees in Turkey, tracking women throughout their residence in prewar Syria (before the conflict began in 2011), postwar Syria (after the conflict began but before arrival in Turkey), and Turkey. We find that early marriage was more prominent among refugees who were unmarried at the time of migration than among those married before migration; the mean marriage age dropped from 19.

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