Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity.

Aristolochic Acid I (AAI) is widely present in traditional Chinese medicines derived from the Aristolochia genus and is known to cause significant damage to renal tubular epithelial cells. Genome-wide screening has proven to be a powerful tool in identifying critical genes associated with the toxicity of exogenous substances. To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line.

Dipeptidyl peptidase-4 inhibitor linagliptin reduces inflammatory response, ameliorates tissue edema formation, and improves survival in severe sepsis.

Background: Excessive inflammation in sepsis causes microvascular dysfunction associated with organ dysfunction and high mortality. The present studies aimed to examine the therapeutic potential of linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in a clinically relevant polymicrobial sepsis model in mice.

Methods: Sepsis was induced by cecal ligation and puncture (CLP).

Limited consensus on what climate anxiety is: Insights from content overlap analysis on 12 questionnaires.

Climate anxiety is a phenomenon that is gaining importance due to the general public's increased awareness of the worsening climate crisis. At present, climate anxiety is not operationalized consistently across the existing literature. It is important to gain more consensus on the definition and operationalization of climate anxiety to facilitate reliable and generalizable research and to further develop interventions.

Future runoff trends in the mang river basin of China: Implications of carbon emission paths.

In recent years, the rapid development of the global economy has led to an increasing impact of the ongoing climate warming phenomenon on the hydrological cycle. In this context, the runoff changes affected by human activities are more severe. This study classifies climate scenarios based on carbon emission levels into "low-carbon" (SSP1-2.

Analysis of carbon reduction potential from typical municipal solid waste incineration plants under MSW classification.

The disposal of municipal solid waste (MSW) is a significant source of greenhouse gas (GHG) emissions. As incineration becomes the primary method of MSW disposal in China, MSW incineration (MSWI) plants are expected to play a crucial role in mitigating GHG emissions in the waste sector. This study estimated the quarterly GHG emissions from two representative MSWI plants in Qingdao using a life-cycle assessment (LCA) approach.

Environmental regulation and corporate exports: Quasi-experimental evidence from China's environmental protection tax law.

How can we create a dual benefit scenario that improves both the ecological environment and export performance? This study aims to investigate whether the introduction of the Environmental Protection Tax Law (EPTL) has promoted the growth of corporate export. By treating the formal implementation of China's EPTL on January 1, 2018, as an exogenous economic event, this paper takes A-share listed companies in China from 2013 to 2022 as a sample and uses the Difference-in-Differences (DID) model to analyze the specific effects of the EPTL on corporate exports. The results indicate that the EPTL improves corporate exports significantly.

Enhancing fish sludge bioconversion kinetics for nutrient recovery in aquaponics using a modified biological aerated filter with a novel media of polyhedral hollow spheres.

Nutrient recovery from aquaculture sludge is vital for promoting hydroponic plant growth and achieving near-zero solid waste discharge in aquaponic systems. Modified biological aerated filters (MBAFs) are promising because of the dual capabilities of aquaculture sludge collection and aerobic mineralization. However, the bioconversion kinetics, which is indirectly related to the packed media, need to be improved.

The role of FDI and energy intensity upon the consolidation of circular economies among the European Union.

This manuscript critically examines the intricate interplay between diverse foreign direct investment (FDI) flows, energy intensity, and their consequential effects on circular economies (CEs), specifically in terms of the waste recycling ratio, within the member states of the European Union over the period spanning from 2000 to 2021. Our findings substantiate that inflows and outflows of FDI have different implications for waste recycling, where an increase of 1% OFDI implies an increase of recycling ratio by 0.03%, a relationship that is potentially contingent upon the inherent characteristics of the flow itself in relation to its contributions to local productivity dynamics.

Three-Year Clinical Outcomes in Geographic Atrophy: An Analysis of 18,712 Patient Eyes.

Methods: Retrospective analysis of 18,712 eyes with GA using the CorEvitas Vestrum Health Retina Database.

Results: Mean age at index was 78.6 years (SD = 7.

Development of posttransplant diabetes mellitus in US recipients of liver transplant is influenced by OPTN region.

Posttransplant diabetes mellitus (PTDM) is associated with significant morbidity and mortality in liver transplant recipients (LTRs). We used the Organ Procurement and Transplantation Network (OPTN) database to compare the incidence of developing PTDM across the United States and develop a risk prediction model for new-onset PTDM using OPTN region as well as donor-related, recipient-related, and transplant-related factors. All US adult, primary, deceased donor, LTRs between January 1, 2007, and December 31, 2016, with no prior history of diabetes noted, were identified.

The Effect of Implementation of Skin Care Guidelines on Nurses' Knowledge Regarding Skin Care and Incidence of Skin Injuries Among Neonates at a Private Tertiary Care Hospital.

Background: Skin care of sick newborns is important because skin acts as a barrier to prevent neonates from infections which may lead to neonatal morbidity and mortality. The highly technological environment of the neonatal intensive care unit (NICU) makes them vulnerable to loss of skin integrity. In acute care setting maintenance of skin integrity is considered as an established quality indicator representing nursing care.

Therapeutic Drug Monitoring of High-dose Sulbactam in Pediatric Patients: Preliminary Data From a Prospective Observational Pharmacokinetic Study.

Background: Rates of carbapenem-resistant Acinetobacter baumannii are rising in Thailand. Although high-dose (HD) sulbactam is recommended for treating carbapenem-resistant A. baumannii infections, data on plasma sulbactam concentrations in children are limited.

Ocular and Systemic Abnormalities in Punctal Agenesis.

Background: Punctal agenesis (PA) is a rare congenital anomaly that can occur in isolation or as part of an underlying syndrome. The benefit of genetic assessment in individuals with PA and clinical features that should prompt molecular workup has not been systematically studied. The aim of this study was to identify ocular and extraocular features associated with PA and determine its association with an underlying syndrome.

Lack of progress in cancer related outcomes after Liver Transplantation: Mitigating risk & identifying future needs to move this needle.

Malignancy has a crucial impact on long-term survival after liver transplantation. There has been enhanced early detection rates with refined cancer screening and improved prognosis for many cancer diagnoses in the general population with the advent of targetted anti-cancer therapies. Similar advancements have not occurred in the transplant population over this same timeframe.

Spectroscopic amplifier for ultrahigh plasmonic-based enhancement of the Hyper-Raman scattering procedure.

An anisotropic plasmonic trimer is proposed as an effective spectroscopic amplifier for the maximum signal enhancement of the Hyper-Raman Scattering (HRS) process. The three-particle system is composed of asymmetric Au nanorings arranged collinearly in a J-aggregate configuration and illuminated by a longitudinally polarized light. The optical properties of the considered trimer have been numerically simulated by the Finite-Difference Time-Domain (FDTD) method.

A Longitudinal Analysis of Long Working Hours and the Onset of Psychological Distress.

Objectives: There is a paucity of longitudinal studies examining the relationship between working hours and the development of Psychological Distress (PD) among U.S. workers.

Application of Subretinal Balanced Salt Solution Injection: A Novel technique in treating Severe idiopathic Epiretinal Membrane.

Purpose: To describe a novel surgical approach for treating patients diagnosed with severe idiopathic epiretinal membranes (iERM) featuring ectopic intrafoveal layers (EIFL).

Method: A retrospective, interventional case series was conducted involving eight cases of iERM with EIFL. The technique involved a 27-gauge vitrectomy, removal of all vitreous adhesions, and injection of approximately 100μl sub-retinal balanced salt solution (BSS) using a 41-gauge subretinal needle, creating 3-4 localized bleb-like elevations around the folded retina to loosen it.

Umbilical Amniotic Tissue Graft as an Alternative Approach for Eyelid Reconstruction After Necrotizing Fasciitis Debridement.

A 54-year-old female with myelodysplastic syndrome on chemotherapy presented with 10 days of periocular erythema and edema worsening on oral antibiotics. Computed Tomography scan showed periorbital soft tissue swelling without postseptal extension or abscess. Intravenous broad-spectrum antibiotics were administered.

Career Paths, Practice Location, and Scholarly Contributions of American Society of Ophthalmic Plastic and Reconstructive Surgery Fellowship Graduates, 2000-2021.

Purpose: To characterize American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) fellowship graduates' career paths and contributions to society missions, including trends across gender, time, and geography.

Methods: In this retrospective cohort study, ASOPRS fellowship graduates from 2000 to 2021 were stratified by demographics, time, and geography. Main outcomes were career paths and contributions to ASOPRS missions of advancing education, research, and quality of clinical practice.

Psychiatric Sequelae in Adult Open Globe Injury Patients.

Background: The aim of this study was to investigate psychiatric sequelae in open globe injury patients and to identify the risk factors associated with these sequelae.

Methods: After a complete ophthalmologic examination, Davidson Trauma Scale (DTS), State-Trait Anxiety Inventory (STAI), and Zung Depression Scale (ZDS) scores were administered to all patients. Patients were divided into 5 groups according to final best corrected visual acuity (BCVA): group 1 (no perception of light, NPL), group 2 [perception of light (PL) or hand movements (HM)], group 3 (1/200 to 19/200), group 4 (20/200 to 20/50), and group 5 (20/40 or above).

Speech Outcome Audit for Cleft Lip and Palate Patient Population Correlated With Veau Cleft Type, Surgical Repair Technique, and Patient Age.

Objective: The objective of this study is to determine speech outcome differences for specific palate repair techniques and correlate these data with patient age at the time of operation.

Methods: A retrospective study was conducted on a cohort of consecutive nonsyndromic patients who underwent cleft lip and/or palate repair at the authors' hospital between 2010 and 2020. Only those patients who participated in at least 4 years of follow-up accompanied by audio-video recording were included.

Multidisciplinary Treatment of A Class III Patient With Giant Open Bite Secondary to Macroglossia.

Skeletal Class III malocclusion deformity is one of the most common maxillofacial malocclusions in East Asia and is either due to maxillary retrusion, mandibular protrusion, or both. It could cause functional and aesthetic problems. This deformity could be attributed to either hereditary or environmental factors or both.

Advances in the Treatment of Congenital Infiltrating Lipomatosis of the Face: The Role of PIK3CA Mutations and Microvascular Reconstruction.

Congenital infiltrating lipomatosis of the face is a rare aggressive-benign disorder characterized by progressive hemifacial overgrowth and complex, often asymmetrical, facial differences. Recently linked with the PIK3CA-Related Overgrowth Spectrum, it arises from mosaic mutations in the PIK3CA gene. Treatment, largely supportive and tailored to individual clinical presentations, requires a multidisciplinary approach.

INTEGRATING RADIOLOGICAL IMAGING TECHNIQUES INTO ANATOMY EDUCATION: MEDICAL TRAINING ENHANCEMANT THROUGH EARLY CT AND MRI TEACHING.

Unlabelled: Brain morphology understanding is essential for radiologists, neurologists, and neurosurgeons. Historically, anatomical learning of brain relied on ex vivo specimens. Modern in vivo brain CT and MRI provide spatial, three-dimensional imaging capabilities crucial to help diagnose diseases, plan surgeries, and monitor treatment progress.