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AgNOR counts in preneoplastic lesions of the bronchus.

Pathol Res Pract

April 1994

Institute of Pathology, Berufsgenossenschaftliche Kliniken, Bergmannsheil, Bochum-University Clinic, FRG.

Silver staining of argyrophil nucleolar organizer regions (AgNORs) has become a valuable method to assess cell kinetics in paraffin sections and separate benign from malignant lesions. As a putative technique for the distinction between regenerative and preneoplastic alterations of the bronchial mucosa we employed the Ag-staining method, evaluating the number of dots/nucleus and shape of the dots. Dots/nucleus were counted by by standardized methods, and mean and standard deviation were calculated.

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