3 results match your criteria: "Blood and Viral Diseases Research Center[Affiliation]"

Tailored prophylaxis in children with severe hemophilia: A four-year Iranian study.

Transfus Apher Sci

December 2021

Iranian Comprehensive Hemophilia Care Center, Tehran, Iran; Iranian Comprehensive Hemophilia Care Center, Blood and Viral Diseases Research Center, Tehran, Iran. Electronic address:

Background: Prophylaxis the current standard care for patients with severe hemophilia should be planned to optimize the replacement therapy and minimize bleeding. We report our single-center experience of tailored prophylaxis in children affected by hemophilia A (HA) and hemophilia B (HB).

Methods: This study was conducted on 55 patients, under 15 years, with HA (PWHA, n: 46) and HB (PWHB, n: 9) between 2015 and 2019.

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Article Synopsis
  • Congenital combined bleeding disorders (CBDs) are rare and often related to consanguineous marriages, presenting symptoms from minor bleeding to severe complications.
  • The study evaluated 450 patients at the Iranian Comprehensive Hemophilia Care Center, identifying FV-FVII deficiency and FVII-FX deficiency as the most prevalent types among the analyzed cases.
  • Findings highlighted that a significant number of patients experienced postoperative bleeding, and the majority received on-demand treatment rather than preventative care, indicating a need for better management strategies in Iran.
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