810 results match your criteria: "Blood Transfusion Research Center[Affiliation]"

Article Synopsis
  • Regulation of visual system function relies on precise gene regulation, with dysregulation of miRNAs like MIR-96 linked to eye disorders, including diabetic retinopathy (DR) and glaucoma.
  • MIR-96, found in the retina, affects inflammatory and insulin signaling pathways and its role in gene expression was studied by overexpressing it in human retinal pigment epithelial cells, revealing varying effects on target gene expression.
  • The results indicated that changes in the expression of IRS2, a key gene, are connected to disrupted retinal insulin signaling in DR, suggesting that the IRS/PI3K/AKT/VEGF pathway could be a potential treatment target for diabetic complications in the eye.
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  • The study investigated the effects of interval aerobic exercise on hepcidin, ferritin, and liver enzymes in adolescents with beta-thalassemia major over 8 weeks.
  • A total of 26 adolescents were randomly assigned to either a control group or a training group, with training consisting of 3 sessions per week of aerobic exercise at moderate intensity.
  • The results indicated that after 8 weeks, aerobic training decreased levels of ferritin and hepcidin, while acute bouts of exercise increased these levels immediately after working out.
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  • Von Willebrand disease (VWD) is prevalent and this study focused on patients in Zahedan, Iran, analyzing demographic factors and symptoms.
  • The research included 76 VWD patients, finding that most were diagnosed between ages 1-5, with type III VWD being the most common.
  • High rates of family history and consanguineous marriages were noted, highlighting the need for early diagnosis and better healthcare services for those at risk.*
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Background: Human chorionic gonadotropin (hCG) is a polypeptide hormone synthesized during pregnancy and is also upregulated in some pathologic conditions such as certain tumors. Its measurement is essential for diagnosing pregnancy and malignancies. Despite numerous attempts to introduce an accurate method capable of detecting hCG levels, several limitations are found in previous techniques.

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Article Synopsis
  • - The study explores the levels of interleukin-6 (IL-6) and interleukin-10 (IL-10), along with the expression of various genes associated with immune regulation, in newly diagnosed rheumatoid arthritis (RA) patients before and after treatment with DMARDs compared to healthy individuals.
  • - Results indicated that RA patients had significantly higher IL-6 levels and lower IL-10 levels before treatment, but IL-6 decreased and IL-10 increased post-treatment with DMARDs, showing an improvement in their inflammatory profiles.
  • - Gene expression analysis showed that certain regulatory genes (FoxP3, Sema-3A, Nrp-1) were upregulated after treatment, indicating a beneficial effect
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Article Synopsis
  • Chronic inflammation, particularly through interleukin-6 (IL-6), is linked to both rheumatoid arthritis (RA) and cardiovascular disease (CVD), with IL-6 levels correlating to joint damage and disease severity.
  • A study involving 60 RA patients and 30 healthy controls found that IL-6 levels were significantly higher in RA patients, correlating with several CVD risk assessment tools (Framingham Risk Score and SCORE) and markers like NT-proBNP and HS-CRP.
  • The findings suggest that elevated IL-6 may serve as a potential biomarker for predicting cardiovascular risks in patients with rheumatoid arthritis.
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Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme disorder in red blood cell (RBC). Due to the importance of G6PD enzyme as an antioxidant in RBC, we tried to investigate the oxidative damage in red cell concentrates (RCCs) prepared from donors with G6PD enzyme deficiency in comparison with healthy donors.

Material Method: This cross-sectional study was conducted on 20 male donors.

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During coronary artery bypass grafting (CABG), the surgical procedure, particularly the manipulation of the major arteries of the heart, induces a significant inflammatory state that may compromise platelet function to the extent that platelet transfusion is required. Given stored platelets as a major source of biological mediators, this study investigates the effects of platelet transfusion on the major pro-aggregatory, pro-inflammatory and immunomodulatory markers of platelets. Platelets from 20 patients, 10 who received platelet transfusion and 10 without, were subjected to flow cytometery where P-selectin and CD40 ligand (CD40L) expressions and PAC-1 binding (activation-specific anti GPIIb/GPIIIa antibody) analysed at five-time points of 24 h before surgery, immediately, 2 h, 24 h and 1 week after surgery.

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Introduction: According to WHO, Breast cancer is widely considered to be the first or second cause of cancer-related death almost universally. Cell cycle disruption, either in the form of uncontrolled expression of cyclins or because of the suspension in negative regulatory proteins (CDK inhibitors), was found to cause breast cancer. Palbociclib as specific CDK4/6 inhibitor is used for the treatment of ER+ metastatic cancers.

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Article Synopsis
  • The study focuses on the issue of high alloimmunization rates in sickle cell disease (SCD) patients, emphasizing the importance of accurately determining blood group genotypes to enhance blood compatibility and reduce risks.
  • 104 SCD and sickle thalassemia patients were analyzed using Tetra ARMS PCR for Rh genotyping, revealing a variety of genotypes while highlighting discrepancies between molecular and serological methods in 11 cases.
  • The findings suggest that combining Tetra ARMS PCR with traditional serological techniques is a significant advancement in immunohematology, improving patient care during blood transfusions.
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Long-term prediction of Iranian blood product supply using LSTM: a 5-year forecast.

BMC Med Inform Decis Mak

July 2024

Department of Epidemiology and Biostatistics, School of Health, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Background: This study aims to predict the trend of procurement and storage of various blood products, as well as planning and monitoring the consumption of blood products in different centers across Iran based on artificial intelligence until the year 2027.

Methods: This research constitutes a time-series investigation within the realm of longitudinal studies. In this study, information on the number of packed red blood cells (RBC), leukoreduced red blood cells (LR-RBC), and platelets (PLT), PLT-Apheresis, and fresh frozen plasma (FFP) was requested from all blood transfusion centers in the country and extracted using a unified protocol.

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Purpose: To investigate the short-term effects of low-level lasers (LLLs; also known as low-power laser therapy) on the structure, genetic, and phenotype of cultured human retinal pigment epithelial (hRPE) cells from both adult and neonatal sources.

Methods: Cultivated adult and neonatal hRPE cells were irradiated with two types of LLL (630 nm and 780 nm), 1 min daily for five consecutive days.

Results: An increase in doubling time was observed in 630 nm-irradiated adult hRPE cells ( = 0.

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Objective: Trace elements (TEs) have electrochemical and catalytic effects and play a crucial role in metabolism. A change in the concentrations of specific TEs may be associated with the incidence of various diseases such as solid tumors and hematological malignancies. By comparing the concentrations of TEs in the cases and controls, this study aims to provide insights into the possible impacts of TEs concentration on the incidence of leukemia and lymphoma.

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Introduction: Patient blood management (PBM) is outlined as evidence-based medical and surgical concepts with a multidisciplinary method.

Aims And Objectives: The aim of this article is to review the PBM implementation and analyses the issues, challenges, and opportunities.

Methodology: In this article, we have an overview of PBM implementation in literature and our experience in one hospital in Iran.

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Background: Red blood cell (RBC) units undergo metabolic, structural, and biochemical changes known as "storage lesions" that can reduce the survival and quality of RBCs. The use of antioxidants such as α-tocopherol may help to improve the quality of RBC units by reducing oxidative stress. The aim of this study was to determine the antioxidant effect of α-tocopherol in RBC units containing citrate-phosphate-dextrose solution with adenine (CPDA1) stored at 1°C-6°C for 35 days.

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Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. However, in rare cases, it is reactive at 37°C or shows hemolytic transfusion reactions. The presence of high thermal amplitude of anti-P1 cannot be ignored and requires cross-match compatible red blood cells for transfusion.

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Non-Hodgkin lymphomas (NHLs) are heterogeneous and are among the most common hematological malignancies worldwide. Despite the advances in the treatment of patients with NHLs, relapse or resistance to treatment is anticipated in several patients. Therefore, novel therapeutic approaches are needed.

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The genetics of hereditary hemochromatosis (HH) is understudied in Iran. Here, we report the result of genetic screening of 854 individuals, referred as "suspected cases of HH," to a diagnostic laboratory in Iran over a 12-year period. From 2011 to 2012, 121 cases were screened for HH using Sanger sequencing of exons.

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Background: Platelet storage is complicated by deleterious changes, among which reduction of ristocetin-induced platelet aggregation (RIPA) has a poorly understood mechanism. The study elucidates the mechanistic roles of all the possible players in this process.

Research Design And Methods: PRP-platelet concentrates were subjected to RIPA, collagen-induced platelet aggregation (CIPA), and flowcytometric analysis of GPIbα and PAC-1 binding from days 0 to 5 of storage.

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Awareness and practical evaluation of correct use of iron chelators; a study to track the ambiguities of thalassemia patients on their medications in Iran.

BMC Res Notes

June 2024

Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 3rd floor of the school of pharmacy, 2660th Valiasr Street, Niyayesh junction, Tehran, 1996835113, Iran.

Purpose: This study aimed to evaluate the knowledge, attitude, and practice toward iron chelating agents (ICAs) in Iranian thalassemia major patients.

Methods: A total of 101 patients with thalassemia major were involved in this cross-sectional survey. A deep medication review was done, and participants' knowledge, attitude, and practice were evaluated by a validated instrument based on a 20-scoring system.

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Torque teno virus (TTV) is a globally prevalent virus in humans, yet comprehensive knowledge about its prevalence, predominant transmission routes, and pathogenesis remains limited. This study aimed to assess the frequency of TTV infection among healthy blood donors in Yazd, Iran. A total of 236 healthy blood donors, devoid of HIV/HBV/HCV infection markers, participated in the study from 2015 to 2016.

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Article Synopsis
  • The study focused on occult hepatitis B infection (OBI) in blood donors who tested negative for the hepatitis B surface antigen (HBsAg) in Mashhad, Iran.
  • Researchers tested serum samples from 540 HBsAg-negative donors for antibodies against HBV core antigen (anti-HBc) and found that 5.4% were anti-HBc positive, but no HBV DNA was detected in any of the samples.
  • The study suggests that blood donations in Iran should be routinely screened for anti-HBc and anti-HBs antibodies, rather than for HBV DNA.
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Background And Objectives: HSV-1 is known as a very contagious virus and the main cause of cold sores or fever blisters. Herein, the aqueous extract of L. was evaluated for its anti-HSV-1 activity, compared to the standard control (acyclovir).

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Snake venoms are rich in valuable substances that have medical potential in the diagnosis and treatment of hemostatic diseases. The present paper was aimed at the purification and functional characterization basis of a thrombin-like enzyme and its role in the functioning of the coagulation cascade and platelet aggregation pathway. A thrombin-like serine protease was purified from the Iranian venom (TLIECV), employing a one-step chromatographic procedure.

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Effect of R882H Hot Spot Mutations on Promoter Methylation in Acute Myeloid Leukemia.

Biomed Res Int

May 2024

Regenerative Medicine, Organ Procurement and Transplantation Multi-Disciplinary Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Epigenetic alterations have been observed in many hematological malignancies, including acute myeloid leukemia (AML). Many of these alterations result from mutations in DNA methyl transferase (DNMT) enzymes, disabling them to methylate target genes in a proper way. In this case-control study, we investigated the association between R882H mutation in gene and gene methylation in patients with AML.

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