13,943 results match your criteria: "Blood Substitutes"

Purpose: Currently, maxillary sinus floor (SF) elevation is based on off-the-shelf allogeneic, xenogeneic or synthetic bone augmentation materials (BAM) that are implanted via an open lateral sinus wall approach (OSFE). However, this invasive method is associated with postoperative complications caused by an inadequate blood supply of the alveolar ridge. Balloon-assisted procedures are minimal invasive alternatives with lower complication rates.

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Sacha Inchi oil (SIO) and hybrid palm oil (HPO) are potential sources of unsaturated fatty acids to improve the lipid profile of dairy products. This study evaluated, for the first time, the effects of the daily consumption of yogurts with enhanced fatty acid profiles on plasma lipids related to cardiovascular disease (CVD) risk factors. A pilot, randomized, double-blind, parallel-controlled trial was conducted with 47 participants assigned to three groups: SIO-enriched yogurt (Group A), HPO-enriched yogurt (Group B), and plain yogurt (Group C).

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Super-hydrophilic and super-lubricating Zwitterionic hydrogel coatings coupled with polyurethane to reduce postoperative dura mater adhesions and infections.

Acta Biomater

December 2024

Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China; Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering(MOE), Tianjin University, Tianjin 300072, PR China. Electronic address:

The dura trauma or large defects due to neurosurgical procedures can result in potential complications. Dural replacements have proven effective to reduce the risk of seizures, meningitis, cerebrospinal fluid leakage, cerebral herniation, and infection. Although various artificial dural patches have been developed, addressing iatrogenic infections and cerebral adhesions resulting from patches implantation remains a challenge.

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Background: Accumulative excessive physical load elevates central arterial stiffness and smooth muscular tone of peripheral vascular beds in endurance athletes. The aim of this study was to test the hypothesis that a brief series of soccer matches would increase central arterial stiffness and arterial wave reflection from the periphery in young female football players.

Methods: Fifteen subjects (17.

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Plant-based meat alternatives and cardiometabolic health: A systematic review and meta-analysis.

Am J Clin Nutr

December 2024

Diet, Planetary Health and Performance, Faculty of Health Sciences, Universidad Francisco de Vitoria, Pozuelo, 28223 Madrid, Spain; School of Physiotherapy, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain.

Article Synopsis
  • Plant-based meat alternatives (PBMAs) are becoming popular, but their impact on heart and metabolic health is not clearly known.
  • A systematic review of 7 randomized controlled trials involving 369 adults found that replacing meat with PBMAs significantly reduced low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), and body weight.
  • The study concludes that substituting PBMAs for meat for up to 8 weeks can lead to improvements in cardiometabolic health indicators for adults without cardiovascular diseases.
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  • A large number of systematic reviews and meta-analyses have examined the impact of sodium intake on cardiovascular health, but the overall quality and consistency of these studies haven't been clearly summarized.
  • An umbrella review was conducted to evaluate the strength of the evidence linking lower sodium intake to better cardiovascular outcomes, using rigorous quality assessment tools.
  • The findings indicated that reducing sodium intake can significantly lower blood pressure and might reduce the risk of major cardiovascular events, especially in individuals with lower cardiovascular risk, with some benefits noted from using salt substitutes.
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  • The study focuses on developing a bioactive artificial vascular graft to improve endothelialization and reduce implantation failures caused by poor biomimetic fabrication and anti-thrombosis processes.
  • The graft is designed with a tri-layer structure using citrate, specific peptides for cell enrichment, and carboxymethyl chitosan to provide anti-thrombosis properties.
  • Additionally, a gastrodin coating is used to minimize inflammation and enhance safety, with evaluations conducted on biocompatibility and other beneficial effects for potential clinical use.
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Artificial blood-hope and the challenges to combat tumor hypoxia for anti-cancer therapy.

Med Biol Eng Comput

November 2024

Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Amity Education Valley, Panchgaon, Manesar (Gurugram), Haryana, 122413, India.

Article Synopsis
  • - Blood is essential for the body, transporting hormones, regulating temperature and pH, and playing a key role in immune defense and healing through white blood cells and platelets.
  • - The circulatory system, made up of arteries, veins, and capillaries, ensures the efficient delivery of nutrients and oxygen but often faces challenges like shortages and compatibility issues, making artificial blood alternatives important.
  • - Our study focused on using artificial blood, including red blood cell substitutes and artificial platelets, to improve cancer therapy by addressing issues like tumor hypoxia and enhancing treatment outcomes.
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  • Platelet-rich fibrin (PRF) is made from a patient's own blood and is used in dental procedures to enhance bone healing and stability when mixed with bone grafts.
  • A study at the University Hospital Innsbruck analyzed the effectiveness of PRF in preventing vertical bone loss after dental implants, involving 362 implants in 170 patients between 2018 and 2021.
  • Results showed that PRF use was linked to reduced vertical bone loss (> 1 mm) but did not significantly affect the number of lost implants or type of augmentation, indicating it could improve graft stability in oral implant procedures.
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The Effect of Grouper Bone Nano-Calcium (GBN) and Medium-Chain Triglyceride (MCT) Supplementation on the Ovariectomized Rats.

J Nutr Metab

November 2024

Micro-CT Laboratory, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung 40132, Indonesia.

Article Synopsis
  • - The research aimed to determine the effects of replacing synthetic calcium carbonate (CaCO) with grouper bone nano-calcium (GBN) and using medium-chain triglycerides (MCT) instead of long-chain triglycerides (LCT) in the diets of ovariectomized rats over eight weeks.
  • - Four groups of twenty rats were studied, with results showing that those fed with GBN exhibited better bone density and strength compared to the synthetic CaCO group, while the calcium-deficient group performed poorly.
  • - The study concluded that GBN was an effective alternative to synthetic calcium and that MCT performed similarly to LCT, though it did not prove superior.
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  • - The study addresses challenges in emergency transfusion medicine due to limitations in traditional blood supply systems, proposing a new hemoglobin-based oxygen carrier (HBOC) enhanced with dual coatings of metal phenolic networks (MPNs) and polyethylene glycol (PEG) for better biocompatibility and stability. - Research results show that the novel HBOC, made with zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, effectively reduces hemoglobin release and minimizes unwanted interactions with blood clotting factors while demonstrating improved circulation times in live tests. - Although both MPN-coated and PEGylated versions of the HBOC displayed similar organ accumulation patterns, the study suggests further research to confirm their effectiveness in treating hemorrhagic shock,
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Antimicrobial peptides (AMPs) are gaining popularity as potential substitutes for conventional antibiotics and bio-preservatives in response to an increase in antimicrobial resistance cases. However, their poor pharmacokinetic profiles limit their applicability. This study using ADMETlab, OECD QSAR toolbox, and VEGA HUB virtual environments profiled 82 peptide sequences of seven bee antimicrobial peptides (BAMPs: abaecin, apamin, apisimin, apidaecin, defensin, hymenoptaecin, and melittin) using 81 descriptors combining physicochemical, medicinal chemistry, ADMET, and toxicophore criteria.

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In this study, we evaluated the impact of yeast cell wall prebiotics and multispecies probiotics on the gut microbiota, immune response, and growth performance of weaned piglets, as alternatives to antibiotics as growth promoters (AGPs). A randomized complete block design was employed, involving 160 piglets divided into four treatment groups during the nursery phase. The treatments applied throughout the experimental period were as follows: CONT+ = basal diet with halquinol (AGP); YCW = basal diet with yeast cell wall (cell wall of Saccharomyces cerevisiae yeast); SIM+ = basal diet with yeast cell wall + multispecies probiotic (Bacillus subtilis (2.

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  • The study aimed to compare gastrointestinal symptoms in healthy Brazilian infants fed goat milk-based formula (GMF) versus cow's milk-based formula (CMF) over a 24-week period.
  • Results showed that both formulas resulted in low and similar gastrointestinal symptoms, with infants experiencing adequate growth and normal hemoglobin levels.
  • The conclusion inferred that GMF is safe, well-tolerated, and supports proper growth, with similar outcomes to CMF in terms of health standards.
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  • - Immune effector cell-associated hematotoxicity (ICAHT) is a common toxicity linked to CAR T-cell therapy, notably affecting patients with various lymphomas and multiple myeloma, but has not been previously studied in B-cell acute lymphoblastic leukemia (B-ALL).
  • - In a study involving 156 young patients with relapsed/refractory B-ALL, severe neutropenia was observed for a median of 13 days, with over half experiencing significant ICAHT, which indicated the need for better predictive models for this condition.
  • - The researchers developed the ALL-Hematotox (ALL-HT) score, improving on existing models by incorporating bone marrow disease burden, which accurately predicted severe neutrop
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  • Scaphoid nonunions are challenging for hand surgeons due to the scaphoid's poor blood supply, leading to the need for internal fixation and bone grafts for treatment.
  • Various bone graft options exist depending on the patient's condition, blood supply, and any deformities, including nonvascularized autologous grafts from different body areas and vascularized grafts for blood supply concerns.
  • The review emphasizes the importance of using bone grafts to enhance internal fixation, promote healing, and restore alignment in cases of scaphoid nonunions.
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Lost in translation: the lack of agreement between surgeons and scientists regarding biomaterials research and innovation for treating bone defects.

BMC Med

November 2024

Australian Research Council (ARC) Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing (M3D Innovation), Queensland University of Technology, Brisbane, QLD, 4000, Australia.

Background: With over 2 million grafts performed annually, bone ranks second only to blood in the frequency of transplants. This high demand is primarily driven by the persistent challenges posed by bone defects, particularly following trauma or surgical interventions such as tumour excision. The demand for effective and efficient treatments has increased exponentially in the twenty-first century.

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Subarachnoid hemorrhage (SAH) is the deadliest form of hemorrhagic stroke; however, effective therapies are still lacking. Perfluorocarbons (PFCs) are lipid emulsion particles with great flexibility and their much smaller size as compared to red blood cells (RBCs) allows them to flow more efficiently within the blood circulation. Due to their ability to carry oxygen, a specific PFC-based emulsion, PFC-Oxygent, has been used as a blood substitute; however, its role in cerebral blood flow regulation is unknown.

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High-molecular-weight (HMW) (>500 kDa) glutaraldehyde-polymerized human hemoglobin (PolyhHb) is a promising hemoglobin-based oxygen carrier (HBOC) due to its decreased risk of vasoconstriction and oxidative tissue injury. Previously, HMW tense (T) quaternary state PolyhHb was synthesized at the pilot scale with tangential flow filtration (TFF) for the removal of low-molecular-weight species. However, T-state PolyhHb is limited to specific biomedical applications due to its low oxygen affinity, thus motivating the need to produce high oxygen affinity relaxed (R) quaternary state PolyhHb at the pilot scale.

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The purpose of this study was to provide an evaluation of two different xenogeneic bone substitutes in bone healing of critical-sized bone defects (Ø =5mm) created in rats calvaria. Thirty animals were randomized into 3 groups with one of the following treatments. In the control group (n=10), the defects were filled with blood clots; BO group (n=10), the defects were filled with bovine medullary bone substitute (Bio-Oss®); BF group (n=10), the defects were filled with bovine cortical bone substitute (Bonefill®).

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Background: Platelet-rich plasma (PRP) formulations have become valuable therapeutic tools in regenerative medicine. In addition, these blood derivates have been successfully included in cell therapy as fetal bovine serum substitutes, due to the real need to avoid the risk of host immunologic reactions and the animal disease transmission associated with reagents from animal origin. However, the protocols for obtaining them should be optimized to improve their biological potential.

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Introduction Eosin stain is a commonly used histological dye that selectively binds to acidic structures in cells, imparting a color between pink and red. Eosin stain can be harmful due to its chemical composition. Inhaling eosin stain in powder form or as aerosolized droplets can cause irritation in the respiratory tract.

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  • The text discusses California's Proposition 65, which aims to reduce consumer exposure to toxic chemicals by creating a list of harmful substances and discouraging businesses from using them.
  • The study evaluates national biomonitoring data to determine whether Prop 65 has successfully reduced exposure to these chemicals, focusing on changes in blood and urine concentrations among participants over time.
  • Results indicate that while the concentration of listed chemicals like Bisphenol A (BPA) declined, some non-listed but related chemicals (like Bisphenol S) increased, suggesting businesses may be substituting one harmful chemical for another.
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