The Role of Pyroptosis-Related Gene Signature and Immune Infiltration in Juvenile Dermatomyositis.

Objective: Juvenile dermatomyositis (JDM) is a complex autoimmune disease, and its pathogenesis remains poorly understood. Building upon previous research on the immunological and inflammatory aspects of JDM, this study aims to investigate the role of pyroptosis in the pathogenesis of JDM using a comprehensive bioinformatics approach.

Methods: Two microarray datasets (GSE3307 and GSE11971) were obtained from the Gene Expression Omnibus database, and a list of 62 pyroptosis-related genes was compiled.

Psychological Intervention for Depression and Anxiety in Hemodialysis Patients: A Meta-Analysis.

Background: With the advancement of blood purification technology, there is increasing attention to the mental health of hemodialysis patients, particularly concerning depression. This study aims to determine the effect of psychological interventions on anxiety and depression in hemodialysis patients through a meta-analysis.

Methods: A computerized search was conducted to identify randomized controlled trial (RCT) studies published in PubMed, Embase, Web of Science, ScienceDirect, and Cochrane Library databases from their inception to October 2023, focusing on the effects of psychological interventions on improving depression in hemodialysis patients.

A nomograph model for predicting the risk of diabetes nephropathy.

Objective: Using machine learning to construct a prediction model for the risk of diabetes kidney disease (DKD) in the American diabetes population and evaluate its effect.

Methods: First, a dataset of five cycles from 2009 to 2018 was obtained from the National Health and Nutrition Examination Survey (NHANES) database, weighted and then standardized (with the study population in the United States), and the data were processed and randomly grouped using R software. Next, variable selection for DKD patients was conducted using Lasso regression, two-way stepwise iterative regression, and random forest methods.

Investigation of polyvinylpyrrolidone-catechol-derived chitosan nanoconjugates allowed for kidney-targeted treatment of cisplatin-induced acute kidney injury and nursing care management.

Acute kidney injury (AKI) resulting from cisplatin (Cs) chemotherapy presents a significant challenge in clinical management. The study aimed to fabricate a novel compound Polyvinylpyrrolidone-catechol-derived chitosan nanoconjugates (PCChi-NC) for targeting Cs-induced AKI. Characterization studies utilizing UV-visible spectrophotometry, FT-IR, XRD, and TEM revealed a spherical morphology with diameters ranging from 20 to 60 nm.

Vitamin D: an important treatment for secondary hyperparathyroidism in chronic kidney disease?

Secondary hyperparathyroidism (SHPT) is one of the most common complications of chronic kidney disease (CKD). Vitamin D levels begin to decrease in the early stages of CKD, and these vitamin D-related changes play a central role in the occurrence and development of SHPT. Vitamin D-based drugs, which inhibit parathyroid hormone secretion either directly or indirectly, are commonly used to treat SHPT.

Analysis of the mediating effect of social status perception on professional identity and work engagement of blood purification nurses.

To explore the relationship between social status perception, professional identity, and work engagement among nurses involved in blood purification, and to provide a theoretical basis for improving the professional identity and work engagement of blood purification nurses. A convenient sampling method was used to distribute questionnaires to 81 nurses specializing in blood purification in Beijing. The MacArthur scale was used to verify the social status perception of the study subjects.

Correlation Analysis of Blood Pressure Variability, Crystalloid Osmotic Pressure, and Cardiovascular Events in Maintenance Hemodialysis Patients.

Introduction: This study aimed to analyze the correlation between blood pressure variability (BPV), crystalloid osmotic pressure, and cardiovascular events (CEs) in patients undergoing maintenance hemodialysis (MHD).

Methods: This retrospective analysis was conducted on 71 patients with end-stage kidney disease who underwent hemodialysis at Beilun District People's Hospital from September 2021 to September 2022. The patients were divided into two groups based on the occurrence of CEs: a cardiovascular event group and a non-cardiovascular event group.

Effects of PM components on hypertension and diabetes: Assessing the mitigating influence of green spaces.

Background: Particulate matter with diameters ≤2.5 μm (PM) is a significant air pollutant associated with hypertension and diabetes. However, the specific contributions of its components and their joint exposure with green spaces remain poorly understood, especially in developing regions.

Effects of Visualized Health Education Based on Health Belief Model on Self-Management of Patients Undergoing Maintenance Hemodialysis.

Background: Patients with end-stage renal disease often require maintenance hemodialysis (MHD). Effective self-management is crucial for the prognosis of patients undergoing MHD; however, their self-management practices remain suboptimal.

Objective: This study aimed to explore the effects of visualized health education based on health belief model on self-management, self-efficacy, quality of life, and quality of dialysis in patients undergoing MHD.

The efficacy and safety of belzutifan inhibitor in patients with advanced or metastatic clear cell renal cell carcinoma: a meta-analysis.

Background: The belzutifan is a hypoxia inducible factor-2 alpha (HIF-2α) inhibitor for the treatment of advanced or metastatic clear cell renal cell carcinoma (mccRCC) and has exhibited good safety and efficacy in clinical trials. We conducted a meta-analysis of relevant studies to further clarify the efficacy and safety of belzutifan for the treatment of mccRCC.

Methods: Multiple databases and abstracts from major scientific meetings were systematically reviewed for eligible articles published before June 1, 2024.

What specific exercise training is most effective exercise training method for patients on maintenance hemodialysis with sarcopenia: a network meta-analysis.

Objective: The present study aimed to investigate the influence of different exercise methods on sarcopenia patients receiving maintenance hemodialysis (MHD) by conducting a network meta-analysis.

Methods: The PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang databases were searched online for relevant articles published until May 2024. Based on the inclusion and exclusion criteria, we selected 10 articles that compared the effects of 7 exercise interventions on sarcopenia patients receiving MHD.

A uremic patient with autogenous arteriovenous fistula developed tension blisters after initial puncture.

Tension blisters usually occur in the presence of local swelling or excessive pressure. Tension blisters after puncture injury are relatively rare in uremic patients who use autogenous arteriovenous fistula (AVF) for hemodialysis treatment. In this report, the patient we reported developed tension blisters after the initial puncture injury.

Predictive Value of the Systemic Immune-Inflammation Index in the 28-Day Mortality for Patients with Sepsis-Associated Acute Kidney Injury and Construction of a Prediction Model.

Purpose: The predictive value of the Systemic Immune-Inflammation Index (SII) on mortality in patients with sepsis-associated acute kidney injury (S-AKI) remains unclear. This study aims to investigate the predictive value of SII levels at the Intensive Care Unit (ICU) on the 28-day mortality of S-AKI patients.

Patients And Methods: S-AKI patients admitted to the ICU of Henan Provincial People's Hospital from January 1, 2023, to December 31, 2023.

MiR-92a-3p Promotes Renal Injury and Fibrosis Through Facilitating M1 Macrophage Polarization via Targeting LIN28A.

Infiltrated and activated M1 macrophages play a role in kidney injury and fibrosis during chronic kidney disease (CKD) progression. However, the specific ways that M1 macrophage polarization contributes to renal fibrosis are not fully understood. The study seeks to investigate how miR-92a-3p regulates M1 macrophage polarization and its connection to renal fibrosis in the development of CKD.

ROS responsive nanozyme loaded with STING silencing for the treatment of sepsis-induced acute lung injury.

Acute lung injury (ALI) is a common complication of sepsis and a leading cause of mortality in septic patients. Studies indicate that STING may play a crucial role in the pathogenesis of sepsis-induced ALI by interacting with the PARP-1/NLRP3 pathway. Therefore, targeting STING inhibition has potential as a novel therapeutic strategy for ALI.

Optimal preservation condition for the extraction of cell-free DNA from bile of patients with biliary tract cancer.

Background: Patients with biliary tract cancer (BTC) often have dismal outcomes due to the poor performance of traditional methods for early diagnosis. Recently, bile cell-free DNA (cfDNA) has been reported as a potential liquid biopsy material for BTC diagnosis. However, bile is a complex alkaline aqueous medium, and the proper storage conditions for bile remain to be explored.