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In Denmark, approximately 5% of new mothers experience postpartum depression, potentially hindering a child's care and stimulation for ideal social-emotional development. This literary review explores the impact of maternal postpartum depression on a child's social-emotional development and confirms that maternal postpartum depression potentially harms the child's social-emotional development. Nevertheless, there is cause for optimism in the literature, suggesting that the impact on the child is likely to be transient in cases of shorter durations of postpartum depression.

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Fabry disease (FD) is an X-linked lysosomal storage disease caused by α-galactosidase A deficiency, leading to intralysosomal build-up of glycosphingolipids. In this case report, a 35-year-old male presented with thousands of angiokeratomas, primarily concentrated in the "bathing-trunk" area. Despite numerous visits to doctors in different specialities FD was not suspected.

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Deep dermatophytosis is a rare condition in which dermatophytes invade deep into the skin. Predisposing factors include chronic superficial dermatophytosis, immunosuppression or the use of topical steroids. Clinical, mycological, and histological examination are crucial for accurate diagnosis.

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Early osteoarthritis in patients between 35 and 65 years of age is mostly observed following previous cartilage, meniscus, and bone or ligament injuries. The expectations individuals have regarding their physical abilities have increased over the past few decades. Patients who despite relevant non-surgical treatment still experience knee pain are often a challenge for primary care.

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Abuse of androgenic anabolic steroids (AAS) is associated with a range of cardiovascular side effects, summarized in this review. Apart from being linked to cardiovascular risk factors such as hypertension and dyslipidaemia, AAS abuse is associated with coronary atherosclerosis and imparts a pro-coagulative state, predisposing to thromboembolic disease. Finally, AAS abuse leads to left ventricular hypertrophy and dysfunction, which can ultimately result in heart failure.

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Direct current (DC) cardioversion is an everyday clinical procedure used to restore sinus rhythm from atrial fibrillation. This review summarises the current state of art in Denmark. Sufficient anticoagulation must be ensured before DC cardioversion to reduce the risk of thromboembolism.

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Ingrown toenail is a common condition with many different treatment options. This review finds evidence that mild cases can be treated safely with non-surgical methods like change of ill-fitted shoes and nail brace. With failure in non-surgical treatment or in more severe cases surgical methods can be performed with note to the risk of complications - most frequently infection and the risk of recurrence at 3-13%.

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Recently, semi-synthetic cannabinoids have entered the illegal market and are produced to mimic the psychoactive effects of tetrahydrocannabinol (THC). This is a case report of a 19-year-old man, who was hospitalized due to severe sedation, hypotension and tachy- and bradycardia after ingestion of the semi-synthetic cannabinoids hexahydrocannabinol (HHC) and hexahydrocannabiphorol (HHC-P) mixed in food. HHC-P, HHC and metabolites were identified in blood samples.

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This review describes that a core outcome set (COS) represents a consensus-based minimum set of outcomes to be collected and reported in clinical trials involving a particular disease or population. A COS serves as a guideline for global consensus on which outcome domains should be collected in all clinical trials. After defining what to measure, it becomes crucial to reach consensus on how to measure it.

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Evidence suggests that available antiemetics are equal to intravenous fluid treatment against acute nausea of other causes than motion sickness, pregnancy, anaesthesia, chemo- or radiation therapy. Each antiemetic is associated with adverse effects, which include movement disorders, sedation, and QT prolongation. Intravenous fluid and treatment directed against underlying pathology is recommended as a first-line treatment against nausea in these patients.

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This review summarises the present knowledge of acute foot attacks in patients with diabetes. Diagnosis and treatment of acute foot attacks in patients with diabetes are often delayed, which increases the risk of amputations. To prevent this, urgent action is necessary, as it is for acute myocardial infarction and stroke, to ensure that patients are seen by competent specialists in a multidisciplinary team within hours.

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Mild traumatic brain injury, such as concussion, was once considered self-resolving. However, over the past decade, increased understanding of the short- and long-term impact has led to new guidelines for active management. In this review, we summarise recent findings, covering diagnostic criteria, and management for early and persistent symptoms.

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In the last 30 years, the treatment of obstructive lung diseases, such as asthma and COPD, has seen significant advancements. Introduction of inhaled corticosteroids (ICS) and, more recently, biological treatments has revolutionized care. Biological treatments are very successful in severe asthma and are expected to be approved for COPD soon.

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Modern healthcare requires clinicians to navigate through complex drug treatments. This review offers an overview of sources of drug information which can be used for general medication prescription and for challenging patient populations. Key considerations for pregnant or breastfeeding patients, those with renal impairment, and those with liver dysfunction are discussed.

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A systematic review provides an overview of primary studies investigating a given research question, e.g., the effect of a certain treatment.

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Beak fractures represent a rare subtype of calcaneal fractures with potential risk of soft tissue complications due to compromised local perfusion. Early diagnosis and timely intervention are crucial to prevent necrosis, infection, and soft tissue defects. This case report describes a 71-year-old male with a beak fracture and delayed intervention with reoccurring soft tissue defects.

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In his case report, a 74-year-old physically fit man was evaluated repeatedly for several years in the cardiology department due to dyspnoea on exertion (DOE). Several standard cardiac and pulmonary tests were performed but did not provide sufficient cause for the DOE. Lastly, the patient was evaluated with a cardiopulmonary exercise test (CPET) with simultaneous in- and expiratory gas sampling.

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Ten questions to assess to what degree a clinical practice guideline is likely to be trustworthy: 1) Do the authors have conflicts of interests? 2) Is the clinical question relevant? 3) Have relevant stakeholders been involved? 4) Have methods for study selection been described? 5) Is there a link between evidence and recommendations (transparent methods)? 6) Has the certainty of evidence been assessed? 7) Have the methods for reaching recommendations been described? 8) Are the recommendations unambiguous? 9) Are the recommendations relevant in your situation? 10) Is there an implementation strategy?

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Traumatic fractures are often treated conservatively. Bone healing is a complex process and the complexities of a fracture, bone quality, treatment, and patient factors are all crucial. Routine X-rays and clinical follow-ups are a significant cost to society as well as exposing the patient to increased radiation and should only be performed if there is a risk of complications that may impact the treatment.

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The randomised clinical trial is the most reliable study design to compare the effects of different interventions, however, the methodological quality of randomised clinical trials varies. In this review, the central considerations for critically appraising a randomised clinical trial are described along with an example, terminological references, description of design variants and reporting guidelines and appraisal tools. This review aims at helping clinicians and other users of randomised clinical trials to assess the trustworthiness and relevance of trial results for their own practice.