16,991 results match your criteria: "Birmingham Women & Children's Hospital[Affiliation]"
Assessment of the BODE Index and Its Association With Inflammatory Mediators in Chronic Obstructive Pulmonary Disease (COPD) Patients.
Cureus
October 2024
Department of General Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, GBR.
Background Chronic obstructive pulmonary disease (COPD) is a respiratory condition impacting daily activities of susceptible individuals and increasing the risk of respiratory infections and cardiovascular disease. Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity (BODE) index is applied clinically to measure the survival of COPD patients. Inflammatory mediators, including cytokines and chemokines, significantly contribute to the COPD pathology.
View Article and Find Full Text PDFPatient-Reported Pregnancy Outcomes and Survival in Women with Aortic Valve and/or Aortic Root Replacement.
J Womens Health (Larchmt)
January 2025
Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Our objective was to investigate patient-reported maternal and perinatal outcomes and survival among women undergoing aortic valve and/or aortic root replacement (AVR/ARR). This was a single-center observational study of U.S.
View Article and Find Full Text PDFWhat Parkinson's disease patients say in their own words about their mood and anxiety symptoms.
Parkinsonism Relat Disord
January 2025
Grey Matter Technologies/Modality.ai, San Francisco, CA, USA.
Article Synopsis
- - The study aimed to gather insights from Parkinson's Disease (PD) patients on their mood and anxiety issues by analyzing data from the Parkinson's Disease Patient Report of Problems (PD-PROP).
- - Data from over 21,000 participants revealed four key categories of non-depressive mood symptoms related to PD, with findings indicating women report these symptoms more frequently, and the issues of loneliness and isolation tend to increase as the disease progresses.
- - The research suggests that healthcare providers should pay closer attention to mood-related problems, especially anxiety, loneliness, and negative emotions in female PD patients and those with longer disease duration.
Article Synopsis
- In a study on children with Phenylketonuria (PKU), casein glycomacropeptide (GMP) was compared to phenylalanine-free amino acids (AA) as a protein substitute, focusing on digestion and overall health effects.
- Results showed that GMP significantly improved gastrointestinal symptoms like stomach pain and bloating, although it did not have a major impact on other health markers like renal function or oxidative stress.
- However, GMP's higher phenylalanine content poses challenges for use as a sole protein source in PKU kids due to their low tolerance for phenylalanine.
Genetic Risk Phenotypes for Type 2 Diabetes Differ with Ancestry in US Adults with Diabetes and Overweight/Obesity.
Arch Med Res
November 2024
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Article Synopsis
- Type 2 diabetes (T2D) risk is notably higher among non-Hispanic black (NHB) and Hispanic individuals, and this study investigates whether genetic factors contribute to these racial disparities.
- The research involved analyzing genetic risk scores associated with T2D pathways in a sample of 361 US adults, revealing that NHB participants exhibited higher scores for β-cell and proinsulin function, suggesting significant differences in T2D etiology among racial groups.
- The findings indicate that impaired β-cell function is a key factor for NHB individuals, while issues such as liver dysfunction and insulin resistance are more prevalent in both NHB and Hispanic populations, potentially guiding future personalized treatment strategies for T2D.
Trajectories of depressive symptoms in a population-based cohort of Black and White women from late reproductive age through the menopause transition: a 30-year analysis.
Menopause
December 2024
Departments of Medicine, Obstetrics and Gynecology, and Epidemiology, University of Michigan, Ann Arbor, MI.
Objective: The aim of this study was to examine how depressive symptoms change in midlife and across the menopause transition.
Methods: We conducted a secondary analysis of data from a prospective population-based cohort, the Coronary Artery Risk Development in Young Adults study. We included women (n = 2,160) with ≥3 responses to the Center for Epidemiologic Studies Depression Scale (CES-D) beginning at examination year 5, at approximately 30 years of age, and again at years 10, 15, 20, 25, 30, and 35 (ages 35 through 60 years).
Association of historical redlining and present-day racialised economic segregation with health-care utilisation among individuals with rheumatic conditions in Massachusetts and surrounding areas of the USA: a retrospective cohort study.
Lancet Rheumatol
January 2025
Harvard Medical School, Harvard University, Cambridge, MA, USA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:
Article Synopsis
- This study investigates how historical redlining and current racial and economic segregation affect healthcare access for people with rheumatic conditions in Massachusetts and nearby areas.
- The research involved a cohort of 5597 patients who received care from rheumatology practices affiliated with Mass General Brigham, using data dating back to 2000 and geocoding their addresses with 1930s redlining maps.
- Findings revealed that a significant portion of the patients lived in heavily redlined neighborhoods, highlighting the ongoing impact of structural racism on healthcare utilization and access for marginalized communities.
Association of neighborhood social vulnerability with ovarian cancer survival.
Gynecol Oncol
November 2024
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Womens Research Institute and Foundation, Pittsburgh, PA, United States of America; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, United States of America; Women's Cancer Research Center, Magee-Womens Research Institute and Foundation and Hillman Cancer Center, Pittsburgh, PA, United States of America; Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States of America. Electronic address:
Objective: Social determinants of health (SDOH) impact cancer outcomes. The CDC Social Vulnerability Index (SVI) integrates scores for four neighborhood-based SDOH domains (socioeconomic status, household characteristics, minority status, and housing type/transportation) to assess neighborhood social vulnerability (NSV). While NSV has been associated with overall cancer mortality and lung, breast, colon, and endometrial cancer-specific mortality, the relationship between NSV as defined by the SVI and ovarian cancer outcomes remains unknown.
View Article and Find Full Text PDFData-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.
JAMA Netw Open
November 2024
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.
Article Synopsis
- The study investigates how using small datasets to select an optimal cutoff score for the Patient Health Questionnaire-9 (PHQ-9) can lead to inaccurate results.
- Researchers evaluated whether data-driven methods for cutoff selection resulted in scores that were significantly different from the true population optimal score and if these methods produced biased accuracy estimates.
- Findings showed that many small studies frequently failed to identify the correct optimal cutoff score, particularly in smaller samples, leading to an overestimation of test sensitivity.
Comparative impact of the affordable care act on breast cancer outcomes among women in two US states.
Front Oncol
November 2024
College of Medicine, Howard University, Washington, DC, United States.
Introduction: Since the implementation of the Patient Protection and Affordable Care Act (ACA) and Medicaid expansion, states that adopted the policy have seen reduced uninsured rates. However, it is unclear whether increased healthcare access, particularly for minority and socioeconomically disadvantaged groups, has translated into measurable improvements in health outcomes.
Objective: Our study aims to evaluate the impact of the ACA and Medicaid expansion on breast cancer outcomes in Louisiana, which has implemented the policy, compared to Georgia, which has not, as of 2024.
Acceptability of identification and management of perinatal anxiety: a qualitative interview study with postnatal women.
Front Public Health
November 2024
Centre for Maternal and Child Health Research, School of Health and Psychological Sciences, City, University of London, London, United Kingdom.
Article Synopsis
- * A study involving interviews with 60 women showed that they value individualized, accessible care, but many are unaware of mental health services available to them.
- * Building a trusting relationship with healthcare providers can improve women's willingness to discuss mental health issues and seek help, emphasizing the need for clear information about available support.
Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype.
medRxiv
October 2024
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Article Synopsis
- * This study is the first large-scale analysis examining the relationship between EDS and genetic variations related to OSA severity, using data from over 11,500 samples across diverse populations.
- * Researchers identified 16 genetic targets linked to EDS and OSA, with eight being new discoveries, and discussed potential therapeutic implications involving insulin resistance and nutritional factors for patients with OSA and EDS.
Serum free light chains in a racially diverse population including African Americans and populations from South Africa.
Blood
November 2024
Dana-Farber Cancer Institute, Boston, Massachusetts, United States.
Detection of light chain (LC) monoclonal gammopathies (MG) traditionally relies on serum free LC (FLC) κ, λ, and their ratio (κ/λ) reference ranges based on a mostly White population. We investigated FLC values in a racially diverse population by screening 10,035 individuals for heavy chain MG, identifying 9,028 negative cases whose FLC were measured. Participants included 4,149 from the PROMISE Study (US, n=2,383; South Africa, n=1,766) and 4,879 from the Mass General Brigham Biobank, with 44% self-identifying as Black.
View Article and Find Full Text PDFLong-Term Patient Satisfaction and Surgical Outcomes With Sophono Implants: A Single-Institution Experience.
Cureus
October 2024
Ear, Nose and Throat (ENT), University Hospitals Birmingham NHS Foundation Trust, Birmingham, GBR.
Objectives Percutaneous and transcutaneous bone conduction hearing implants are used in various otological conditions. This study aimed to evaluate patient satisfaction with Sophono implants and their long-term surgical outcomes. Methods This retrospective study was conducted at Queen Elizabeth Hospital, Birmingham, between October 2022 and May 2023.
View Article and Find Full Text PDFImplementation of a national rapid prenatal exome sequencing service in England: evaluation of service outcomes and factors associated with regional variation.
Front Genet
November 2024
National Perinatal Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Article Synopsis
- Prenatal exome sequencing (pES) was introduced in England to improve genetic diagnosis in fetuses with structural anomalies, and the study aimed to analyze its outcomes between October 2021 and June 2022, including diagnostic yield and referral rates.
- Out of 475,089 births, the pES referral rate was 8.6 per 10,000, with 59% of referred women undergoing testing; 35% of those received a definitive diagnosis, averaging a turnaround time of 15 days.
- The study found significant variations in outcomes based on diagnostic results, with 40% of women with a definite diagnosis choosing termination of pregnancy, compared to only 18% among those without a diagnosis.
Use of Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs and Cancer Risk.
JAMA Netw Open
November 2024
Division of Rheumatology, Department of Internal Medicine, University of Washington, Seattle.
Importance: The Oral Rheumatoid Arthritis Trial Surveillance demonstrated an increased cancer risk among patients with rheumatoid arthritis (RA) taking tofacitinib compared with those taking tumor necrosis factor inhibitors (TNFis). Although international cohort studies have compared cancer outcomes between TNFis, non-TNFi drugs, and Janus kinase inhibitor (JAKis), their generalizability to US patients with RA is limited.
Objective: To assess the comparative safety of TNFis, non-TNFi drugs, and JAKis among US patients with RA (ie, the cancer risk associated with the use of these drugs among these patients).
Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope.
Rheumatol Adv Pract
November 2024
Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK.
Article Synopsis
- Pain is a significant issue for individuals with inflammatory arthritis (IA), affecting their overall well-being, and current UK pain management often relies on long-term opioids and gabapentinoids without sufficient evidence for their effectiveness.
- Surveys indicate that non-drug therapies for pain relief are not being utilized as much as they could be, highlighting a gap in treatment options.
- The British Society for Rheumatology is creating a new guideline to provide clear, evidence-based recommendations for pain management in IA, aimed at healthcare professionals, patients, and other stakeholders, ensuring comprehensive care for people living with this condition.
Corrigendum: The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort.
Front Neurol
November 2024
Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United States.
[This corrects the article DOI: 10.3389/fneur.2023.
View Article and Find Full Text PDFDeterminant factors and coping strategies for depression among pregnant women: an intervention-based qualitative study in Lahore, Pakistan.
BMC Psychiatry
November 2024
Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Background: The present study is an intervention-based qualitative study that explores the factors causing depression among antenatal women and analyses coping strategies based on the modified version of the Thinking Healthy Programme (THP) intervention in the urban setting of Lahore, Pakistan.
Methods: An exploratory qualitative evaluation approach was used in the present study. The study comprises four phases, i.
Impact of Lifestyle Modifications on the Prevention and Treatment of Pelvic Organ Prolapse.
Int Urogynecol J
November 2024
Department Obstetrics and Gynecology, Alpert Medical School at Brown University, Providence, RI, USA.
Introduction And Hypothesis: This manuscript is a part of the International Urogynecology Consultation (IUC) on pelvic organ prolapse (POP) chapter three, committee three, on the impact of lifestyle modifications (i.e., weight loss, treatment of constipation, activity restriction, etc.
View Article and Find Full Text PDFPrevention and treatment of glucocorticoid-induced osteoporosis in adults: recommendations from the European Calcified Tissue Society.
Eur J Endocrinol
November 2024
Department of Rheumatology, Amsterdam University Medical Center, Amsterdam 1081HV, The Netherlands.
Article Synopsis
- - The report by the European Calcified Tissue Society (ECTS) outlines evidence-based recommendations for preventing and treating glucocorticoid-induced osteoporosis (GIOP) in adults, aimed at healthcare providers who may not specialize in bone health.
- - Experts reviewed the literature and created 25 recommendations that categorize patients based on their fracture risk: medium, high, and very high, considering factors like age and history of fractures for appropriate treatment strategy.
- - Key general measures include optimizing calcium and vitamin D intake, assessing fracture risk regularly for those on glucocorticoids for three months or longer, and minimizing fall risks among patients.
Left Atrial Appendage Closure after Ablation for Atrial Fibrillation.
N Engl J Med
November 2024
From Cleveland Clinic, Cleveland (O.M.W., W.I.S., K.W.); St. Bernards Medical Center and Arrhythmia Research Group, Jonesboro, AR (D.G.N.); the Cardiology Department, European Georges Pompidou Hospital, Paris (E.M.); Cardioangiologisches Centrum Bethanien, Agaplesion Markus Krankenhaus, Frankfurt am Main (B.S.), Catholic Hospital, Sankt Johann Nepomuk, Erfurt (H.E.), and Deutsches Herzzentrum der Charité (DHZC), Campus Benjamin Franklin, Berlin (C.S.) - all in Germany; Iowa Heart Center, West Des Moines (T.H.); Ascension St. Vincent's Medical Center, Jacksonville, FL (S.O.); UPMC Pinnacle, Harrisburg, PA (C.P.); Vanderbilt University, Nashville (A.K.); Phoenix Cardiovascular Research Group, Phoenix AZ (A.S.); South Denver Cardiology, Littleton, CO (S.S.); Grandview Medical Center, Birmingham, AL (J. Osorio); Heart House-Cooper University, Camden, NJ (G.M.); Lindner Center for Research and Education at Christ Hospital, Cincinnati (M.G.); Emory University, Medicine, Atlanta (D.B.D.); St. Vincent Heart Center of Indiana, Indianapolis (J. Olson); the Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (J.E.N.-K.); St. Antonius Hospital, Nieuwegein, the Netherlands (L.V.A.B.); the Population Health Research Institute, Hamilton, ON, Canada (J.S.H.); Brisbane AF Clinic, Greenslopes Private Hospital, Brisbane, QLD, Australia (K.P.P.); Medstar Health Research Institute, Medstar Washington Hospital Center, Washington, DC (F.M.A.); Boston Scientific, Marlborough, MA (K.R., T.C., B.S.S., K.M.S.); and Cardiac Electrophysiology, Mount Sinai Fuster Heart Hospital School of Medicine, New York (V.Y.R.).
Background: Oral anticoagulation is recommended after ablation for atrial fibrillation among patients at high risk for stroke. Left atrial appendage closure is a mechanical alternative to anticoagulation, but data regarding its use after atrial fibrillation ablation are lacking.
Methods: We conducted an international randomized trial involving 1600 patients with atrial fibrillation who had an elevated score (≥2 in men and ≥3 in women) on the CHADS-VASc scale (range, 0 to 9, with higher scores indicating a greater risk of stroke) and who underwent catheter ablation.
Oral Infigratinib Therapy in Children with Achondroplasia.
N Engl J Med
November 2024
From Murdoch Children's Research Institute, Melbourne, VIC, Australia (R.S., S.R.); Hospital Vithas Vitoria, Vitoria-Gasteiz (J.M.D.B.), Hospital Universitario Virgen de la Victoria, Malaga (B.D., A.L.-G.), and Hospital Universitario La Paz, Madrid (M. Salcedo) - all in Spain; Sheffield Children's NHS Foundation Trust, Sheffield (P.A.), Birmingham Women's and Children's NHS Foundation Trust, Birmingham (V.S.), NHS Greater Glasgow and Clyde, Glasgow (H.M.), Manchester University NHS Foundation Trust, Manchester (M. Skae), University Hospitals Bristol and Weston NHS Foundation Trust, Bristol (T.C.), and Guy's and St. Thomas' NHS Foundation Trust, London (M.I.) - all in the United Kingdom; Hôpital des Enfants-Toulouse, Toulouse (J.P.S.), Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon (M.N., M.R.), and Hôpital Necker-Enfants Malades, Paris (V.C.-D.) - all in France; the University of Alberta-Stollery Children's Hospital, Edmonton, Canada (P.K.); Vanderbilt University Medical Center, Nashville (J.P.); Cincinnati Children's Hospital Medical Center, Cincinnati (H.S.); Benioff Children's Hospital Oakland, Oakland (P.H.), and BridgeBio Pharma, San Francisco (D.H., E.M., R.W., Y.B., D.R.) - both in California; and Johns Hopkins University, Baltimore (J.H.-F.).
Article Synopsis
- Achondroplasia is a genetic condition that leads to significant short stature and various medical challenges, and infigratinib is a new treatment being tested for children affected by this disorder.
- A phase 2 study involved 72 children aged 3 to 11, testing varying doses of infigratinib over 6 months, with adjustments possible during a further 12-month period, focusing on the safety and height growth of the participants.
- Results indicated that all participants experienced mild to moderate side effects, but none stopped treatment; most significantly, children in the highest dose group showed a notable increase in height growth compared to baseline, suggesting the treatment could be effective.
Diagnostic accuracy of point-of-care lung ultrasound for community-acquired pneumonia in children in ambulatory settings: A systematic review and meta-analysis.
Ultrasound
October 2024
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Article Synopsis
- - The systematic review aimed to evaluate how effective point-of-care lung ultrasound is compared to chest X-rays for diagnosing community-acquired pneumonia in children and young adults (0-21 years) in outpatient settings.
- - The review analyzed six studies involving 1,099 pediatric patients, finding a pooled sensitivity of 90.9% and specificity of 80.7% for lung ultrasound, indicating it’s quite sensitive but less specific.
- - The authors concluded that while lung ultrasound shows promise for diagnosing pneumonia, further research is needed to address concerns about clinician training, study design, and the reliability of chest radiography as a standard for comparison.