An epidemiological study of holoprosencephaly from a regional congenital anomaly register: 1995-2004.

Background: Adequate contemporary information to counsel patients with a prenatal diagnosis of holoprosencephaly is lacking. We addressed this using data from the West Midlands Congenital Anomaly Register (WMCAR), a population-based malformation register, during a time where technological improvements have been stable and anomaly screening is well established.

Methods: Cases were defined using the ICD 10 code for holoprosencephaly.