7 results match your criteria: "Birmingham (M.K.C.); and the National Institute of Diabetes and Digestive and Kidney Diseases[Affiliation]"
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort.
Respir Res
April 2021
Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Background: There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release of mitochondrial DNA (mtDNA), but plasma cell-free mtDNA has not been previously examined prospectively for associations with clinical COPD measures.
Methods: P-mtDNA, defined as copy number of mitochondrially-encoded NADH dehydrogenase-1 (MT-ND1) gene, was measured by real-time quantitative PCR in 700 plasma samples from participants enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) cohort.
Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults.
N Engl J Med
May 2019
From the University of Colorado, Denver and Children's Hospital Colorado, Aurora (T.H.I.); University of Pittsburgh Medical Center, Pittsburgh (A.P.C.); Cincinnati Children's Hospital Medical Center (T.M.J., S.A.X., M.A.H.) and University of Cincinnati (C.X.), Cincinnati, and Nationwide Children's Hospital and the Ohio State University College of Medicine, Columbus (M.P.M.) - all in Ohio; Texas Children's Hospital, Baylor College of Medicine, Houston (M.L.B.); Baker Heart and Diabetes Institute, Melbourne, VIC, Australia (J.B.D.); John R. Oishei Children's Hospital and Jacobs School of Medicine and Biosciences-SUNY University at Buffalo, Buffalo, NY (C.M.H.); the University of Alabama at Birmingham, Birmingham (M.K.C.); and the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (M.E.E.).
Background: Bariatric surgery results in weight loss and health improvements in adults and adolescents. However, whether outcomes differ according to the age of the patient at the time of surgery is unclear.
Methods: We evaluated the health effects of Roux-en-Y gastric bypass in a cohort of adolescents (161 patients enrolled from 2006 through 2012) and a cohort of adults (396 patients enrolled from 2006 through 2009).
Maximizing geographical efficiency: An analysis of the configuration of Colorado's trauma system.
J Trauma Acute Care Surg
May 2018
From the Division of Acute Care Surgery, Department of Surgery (J.O.J.), University of Alabama at Birmingham, Birmingham, Alabama; Health Services Research Unit (J.O.J.), University of Aberdeen, Aberdeen, United Kingdom; Department of Surgery (E.E.M.), University of Colorado, Denver; Department of Surgery (E.E.M.), Denver Health Medical Center, Denver, Colorado; Department of Computing (H.W.), University of Surrey, Guildford, United Kingdom; Department of Surgery (J.J.M.), R Adams Cowley Shock Trauma Center, Baltimore, Maryland; Department of Surgery (J.D.H.), Medical School, University of Aberdeen, Aberdeen, United Kingdom; Health Services Research Unit (M.K.C.), University of Aberdeen, Aberdeen, United Kingdom; and Schools of Public Health and Medicine (A.S.), University of Colorado, Denver, Colorado.
Background: Trauma center designation in excess of need risks dilution of experience, reduction in research and training opportunities, and increased costs. The objective of this study was to evaluate the use of a novel data-driven approach (whole-system mathematical modeling of patient flow) to compare the configuration of an existing trauma system with a mathematically optimized design, using the State of Colorado as a case study.
Methods: Geographical network analysis and multiobjective optimization, 105,448 patients injured in the State of Colorado between 2009 and 2013, who met the criteria for inclusion in the state-mandated trauma registry maintained by the Colorado Department of Public Health and Environment were included.
Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents.
N Engl J Med
January 2016
From the Cincinnati Children's Hospital Medical Center (T.H.I., T.M.J., M.A.H., M.H.Z., S.A.X.) and the University of Cincinnati (C.R.B.), Cincinnati, and Nationwide Children's Hospital, Columbus (M.P.M.) - all in Ohio; the University of Pittsburgh Medical Center, Pittsburgh (A.P.C.); Texas Children's Hospital, Baylor College of Medicine, Houston (M.L.B.); Women and Children's Hospital, University of Buffalo, Buffalo, NY (C.M.H.); University of Alabama at Birmingham, Birmingham (M.K.C.); and the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (M.H.).
Background: Bariatric surgery is increasingly considered for the treatment of adolescents with severe obesity, but few prospective adolescent-specific studies examining the efficacy and safety of weight-loss surgery are available to support clinical decision making.
Methods: We prospectively enrolled 242 adolescents undergoing weight-loss surgery at five U.S.
Access to specialist care: Optimizing the geographic configuration of trauma systems.
J Trauma Acute Care Surg
November 2015
From the Departments of Surgery (J.O.J., J.D.H.) and Intensive Care Medicine (J.O.J.), Aberdeen Royal Infirmary and Health Services Research Unit (J.O.J., M.K.C.), University of Aberdeen, Aberdeen; Academic Unit of Surgery (J.J.M.), Glasgow Royal Infirmary; and Scottish Ambulance Service (R.L.). Glasgow; Department of Computing (H.W.), University of Surrey, Guildford; and School of Computer Science (S.H.), University of Birmingham, Birmingham, United Kingdom.
Background: The optimal geographic configuration of health care systems is key to maximizing accessibility while promoting the efficient use of resources. This article reports the use of a novel approach to inform the optimal configuration of a national trauma system.
Methods: This is a prospective cohort study of all trauma patients, 15 years and older, attended to by the Scottish Ambulance Service, between July 1, 2013, and June 30, 2014.
Feasibility and utility of population-level geospatial injury profiling: prospective, national cohort study.
J Trauma Acute Care Surg
May 2015
From the Departments of Surgery (J.O.J.) and Intensive Care Medicine (J.O.J.), Aberdeen Royal Infirmary & Health Services Research Unit (J.O.J.,M.K.C.), and Department of Geography and Environment (D.R.G.), University of Aberdeen, Aberdeen; Academic Unit of Surgery (J.J.M.), Glasgow Royal Infirmary, Glasgow City; School of Computer Science (S.H.), University of Birmingham, West Midlands; and Scottish Ambulance Service (R.L)., Edinburgh, United Kingdom; and Key Lab of Intelligent Perception and Image Understanding (H.W.), Ministry of Education, Xidian University, Xi'an, China.
Background: Geospatial analysis is increasingly being used to evaluate the design and effectiveness of trauma systems, but there are no metrics to describe the geographic distribution of incidents. The aim of this study, therefore, was to evaluate the feasibility and utility of using spatial analysis to characterize, at scale, the geospatial profile of an injured population.
Methods: This is a prospective national cohort study of all trauma patients attended to by the Scottish Ambulance Service in a complete year (between July 1, 2013, and June 30, 2014).
Optimizing trauma system design: the GEOS (Geospatial Evaluation of Systems of Trauma Care) approach.
J Trauma Acute Care Surg
April 2014
From the Department of Surgery and Intensive Care Medicine (J.O.J.), Aberdeen Royal Infirmary; Health Services Research Unit (J.O.J., M.K.C.), University of Aberdeen; and Scottish Ambulance Service (R.L., G.E.), Edinburgh; Academic Unit of Surgery (J.J.M.), Glasgow Royal Infirmary, Glasgow; Academic Department of Military Surgery & Trauma (J.J.M.), Royal Centre for Defence Medicine; and School of Computer Science (S.H.), University of Birmingham; and Key Lab of Intelligent Perception and Image Understanding (H.W.), Ministry of Education, Xidian University, Xi'an, China.
Background: Trauma systems have been shown to reduce death and disability from injury but must be appropriately configured. A systematic approach to trauma system design can help maximize geospatial effectiveness and reassure stakeholders that the best configuration has been chosen.
Methods: This article describes the GEOS [Geospatial Evaluation of Systems of Trauma Care] methodology, a mathematical modeling of a population-based data set, which aims to derive geospatially optimized trauma system configurations for a geographically defined setting.