Unveiling the potential of Aspergillus terreus SJP02 for zinc remediation and its driving mechanism.

In present study, 15 morphologically different fungi isolated from rhizopheric soils of an industrial area were screened for their Zn removal efficiency from aqueous solution. Isolate depicting highest potential was molecularly identified as Aspergillus terreus SJP02. Effect of various process parameters viz.

Ion-Ion Structural Correlation and Dynamics of Water in Aqueous NaCl Solutions with a Wide Range of Concentrations.

The behavior of water in concentrated ionic solutions, including supersaturated conditions, is crucial for numerous material and energy conversion processes and fundamental research. All electrolytes whether they "structure-make" or "structure-break" the water structure lead to slower water motion. This study investigates the structure and dynamics of aqueous NaCl solutions across a wide range of concentrations.

Recent Advances in Nanotherapeutics and Theranostics for Squamous Cell Carcinoma: A Comprehensive Review.

Recent advancements in nanotherapeutics have revolutionized cancer treatment through the integration of diagnostic and therapeutic modalities, known as theranostics. This critical review examines the current landscape of nanotherapeutics for various cancers, such as bladder and head and neck squamous cell carcinoma, highlighting current advancements in nanotherapeutics and challenges. Key approaches discussed include biomimetic smart nanocarriers, polymeric smart nanocarriers, inorganic-based smart nanocarriers, and nanorobots.

Coumarin Analogues as Promising Anti-Obesity Agents: In Silico Design, Synthesis, and In Vitro Pancreatic Lipase Inhibitory Activity.

A set of coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for their ability to impede pancreatic lipase (PL) activity. Out of all the analogues, 5dh and 5de demonstrated promising inhibitory activity against PL, as indicated by their respective IC values of 9.20 and 11.

DLCDroid an android apps analysis framework to analyse the dynamically loaded code.

To combat dynamically loaded code in anti-emulated environments, DLCDroid is an Android app analysis framework. DL-CDroid uses the reflection API to effectively identify information leaks due to dynamically loaded code within malicious apps, incorporating static and dynamic analysis techniques. The Dynamically Loaded Code (DLC) technique employs Java features to allow Android apps to dynamically expand their functionality at runtime.

Enhanced antimycotic activity of biomodified copper oxide nanoparticles from indigenous state flowers of Jharkhand: an and approach.

Current study investigates the medicinal applications of (Palash), the state flower of Jharkhand, India, focusing on synthesising biomodified copper oxide nanoparticles (CuO-NPs) and its antifungal properties. Flavonoid content in the flower extract was quantified by aluminium chloride colorimetric analysis. CuO-NPs were synthesised via co-precipitation method and then modified with methanolic flower extract.

Industrial scale-up of flue gas bio-mitigation with chemolithotrophs in packed bed reactors: Exploring metabolite synthesis, mass transfer, and techno-economic analysis.

Elevated emissions of flue gases deteriorate the quality of air, impacting both terrestrial and aquatic ecosystems through their contribution to acid rain and eutrophication. This study examines the bio-mitigation process in a packed bed reactor and its capacity to concurrently decrease the environmental consequences of industrial flue gases (CO, NO, and SO) and wastewater by employing mixed bacterial consortia. The highest biomass productivity achieved during the growth phase was 0.

Substituent-driven ESIPT in Chromeno-pyrroloquinoline probe for differentiating normal and cancer cells.

Despite significant advancements in the structural flexibility and functional diversity of fluorescent molecular sensors, the chromophores often require complex synthetic processes and are typically designed to perform only a specific function. Herein, we have demonstrated the unique features of fluorophores based on a fused coumarin-indole scaffold, which are synthetically available via a one-step reaction. Four fluorophores (ICH, ICEst, ICOMe, and ICNMe2) with varying substituents were synthesized and characterized.

Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing.

Background: Colorectal cancer (CRC) is a complex and increasingly prevalent malignancy with significant challenges in its treatment and prognosis. This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its potential as a therapeutic target, particularly in relation to tumor acidity and immune response.

Methods: The study utilized computational approaches, including receptor-based virtual screening and high-throughput docking, to identify potential SLC4A4 inhibitors.

Mechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery.

Improving the bioavailability  of poorly water-soluble drugs presents a significant challenge in pharmaceutical development. Amorphous solid dispersions (ASDs) have garnered substantial attention for their capability to augment the solubility and dissolution rate of poorly water-soluble drugs, thereby markedly enhancing their bioavailability. ASDs, characterized by a metastable equilibrium where the active pharmaceutical ingredient (API) is molecularly dispersed, offer enhanced absorption compared to crystalline forms.

In vitro culture of the parasitic stage larvae of hematophagous parasitic nematode Haemonchus contortus.

Current research on common parasitic nematodes is limited because their infective stages cannot be propagated in vitro. Here, we report a culture system for developing L4s of Haemonchus contortus, a blood-feeding nematode of ruminants. Our results demonstrated that a proportionate mixture of NCTC-109 to Luria-Bertini (1:2) media promoted the formation of early L4s and then into late L4s upon inclusion of 12.

Navigating liver cancer: Precision targeting for enhanced treatment outcomes.

Cancer treatments such as surgery and chemotherapy have several limitations, including ineffectiveness against large or persistent tumors, high relapse rates, drug toxicity, and non-specificity of therapy. Researchers are exploring advanced strategies for treating this life-threatening disease to address these challenges. One promising approach is targeted drug delivery using prodrugs or surface modification with receptor-specific moieties for active or passive targeting.

Advancements in porous framework materials for chemiresistive hydrogen sensing: exploring MOFs and COFs.

Hydrogen is a zero-emissive fuel and has immense potential to replace carbon-emitting fuels in the future. The development of efficient H sensors is essential for preventing hazardous situations and facilitating the widespread usage of hydrogen. Chemiresistors are popular gas sensors owing to their attractive properties such as fast response, miniaturization, simple integration with electronics and low cost.

Computational investigation of the perylene-TCNQ complex: effects of chalcogen and fluorine substitutions.

Context: Donor-acceptor (D-A) complexes, formed between two or more molecules held together by intermolecular forces, show interesting tunable properties and found applications in diverse fields, including semiconductors, catalysis, and sensors. In this study, we investigated the D-A complexes formed between perylene and 7,7,8,8-tetracyanoquinodimethane (TCNQ) and their chalcogen (S, Se) and fluorine derivatives. It was observed that interaction energies due to complex formation increase while the HOMO-LUMO gaps decrease with chalcogen substitutions.

Vitamin K2 protects against D-galactose induced ageing in mice.

Background: Ageing is a complex process characterized by the gradual deterioration of physiological functions, often leading to a diminished quality of life. Dementia is among the prominent indicators of ageing characterized by cognitive impairment. Animal studies employing D-galactose have provided insights into the mechanisms underlying cognitive decline and neuronal degeneration, resembling features of human brain ageing while Vitamin K2, known for its diverse physiological functions, also have neuroprotective potential.

Fabrication of Stable Ru-Doped Ni0.95Se Nanostructures for Photovoltaic Coupled Electrochemical Water Splitting in Alkaline Medium.

Development of a competent and stable electrocatalyst coupled with photovoltaic system for the generation of green hydrogen, can be a plausible answer to the existing energy crisis. Herein, we have developed Ru doped Ni0.95Se via hydrothermal method as a bifunctional catalyst for overall water splitting coupled with photovoltaic system.

Repurposing the familiar: Future treatment options against chronic kidney disease.

Objectives: Chronic kidney disease (CKD) is a serious health issue with rising morbidity and mortality rates. Despite advances in understanding its pathophysiology, effective therapeutic options are limited, necessitating innovative treatment approaches. Also, current frontline treatments that are available against CKD are not uniformly effective and often come with significant side effects.

Rapid detection of hydrogen peroxide and nitrite in adulterated cow milk using enzymatic and nonenzymatic methods on a reusable platform.

Cow milk is readily adulterated due to its complex properties that can emulsify many adulterants. Among the commonly used adulterants in cow milk are hydrogen peroxide (HP) and nitrite. Commercially available HP is added to extend cow milk's shelf life, while nitrite enters through the tap or pond water added to increase cow milk's volume.

Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications.

Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue remodeling, angiogenesis, and neuroinflammation. It has emerged as a significant player in various neurodegenerative diseases and brain disorders. Elevated CHI3L1 levels have been observed in neurological conditions such as traumatic brain injury (TBI), Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), multiple sclerosis (MS), Neuromyelitis optica (NMO), HIV-associated dementia (HAD), Cerebral ischemic stroke (CIS), and brain tumors.

Advances in CRISPR-Cas systems for kidney diseases.

Recent advances in CRISPR-Cas systems have revolutionised the study and treatment of kidney diseases, including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic kidney disease (DKD), lupus nephritis (LN), and polycystic kidney disease (PKD). CRISPR-Cas technology offers precise and versatile tools for genetic modification in monogenic kidney disorders such as PKD and Alport syndrome. Recent advances in CRISPR technology have also shown promise in addressing other kidney diseases like AKI, CKD, and DKD.

Sequestration of Cr(VI) onto polyethyleneimine-derivatized cellulose and its effect on the enzymatic degradation and microbiome viability.

The extremely hazardous nature of Cr(VI) necessitates its sequestration in a sustainable and effective manner. Cellulose-derived materials, known for their eco-friendly properties, are widely employed in environmental remediation. To improve its adsorption capabilities for heavy metals, cellulose is often derivatized with moieties like amine, thiol, carboxylic acid, etc.

Dual-targeting inhibitors involving tubulin for the treatment of cancer.

Combination therapies play a pivotal role in cancer treatment due to the intricate nature of the disease. Tubulin, a protein crucial for cellular functions, is a prime target in tumor therapy as it regulates microtubule dynamics. Combining tubulin inhibitors with other different inhibitors as dual targeting inhibitors has shown synergistic anti-tumor effects, amplifying therapeutic outcomes.

Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds.

In this review we have compiled multicomponent reactions (MCRs) that produce cyclic structures. We have covered articles reported since 2019 to showcase the recent advances in this area. In contrast to other available reviews on this topic, we focus specifically on MCRs with strong prospects in medicinal chemistry.

Development of a novel and affordable point-of-care kit for rapid detection of urea and glucose adulteration in cow milk.

The increasing global population has raised the demand for cow milk, leading to its adulteration with harmful substances, including urea and glucose, that cause damage to humans when consumed regularly. Hence, this study started with predicting urea and glucose toxicity using ProTox-III software, wherein the results revealed that urea belongs to class IV with an LD value of 6350 mg kg and glucose belongs to class VI with an LD value of 23 000 mg kg. Then, a qualitative colorimetric kit and Fourier-transform infrared (FTIR) spectroscopy were used for the preliminary detection of urea and glucose in cow milk.

Optimizing cryptographic protocols against side channel attacks using WGAN-GP and genetic algorithms.

This research introduces a novel hybrid cryptographic framework that combines traditional cryptographic protocols with advanced methodologies, specifically Wasserstein Generative Adversarial Networks with Gradient Penalty (WGAN-GP) and Genetic Algorithms (GA). We evaluated several cryptographic protocols, including AES-ECB, AES-GCM, ChaCha20, RSA, and ECC, against critical metrics such as security level, efficiency, side-channel resistance, and cryptanalysis resistance. Our findings demonstrate that this integrated approach significantly enhances both security and efficiency across all evaluated protocols.