LncRNA MALAT1 as a potential diagnostic and therapeutic target in kidney diseases.

Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript1 (MALAT1) has emerged as a crucial biomarker and therapeutic target for kidney diseases, including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic kidney disease (DKD), lupus nephritis (LN), and renal cell carcinoma (RCC). LncRNAs are non-coding RNAs that have more than 200 nucleotides that play a crucial role in gene regulation at the post-translational stage, transcriptional, and epigenetic levels. LncRNA MALAT1 regulates gene expression and modulates cellular functions such as proliferation, inflammation, apoptosis, and fibrosis, which are key pathophysiology of kidney diseases.

Tuning Fluorescence Properties of BIM Probes via Clay Integration: Targeting Rifampicin with improved selectivity.

The incorporation of photoactive organic dyes into layered inorganic materials enhances their optical and chemical properties, making them ideal for sensing applications. In this study, Bisindolyl methane (BIM)-based neutral probes were integrated with bentonite clay to explore their sensing capabilities. Probe 1 (unoxidized BIM) and Probe 2 (oxidized BIM) generally exhibited quenched luminescence in solution due to intramolecular rotations.

Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae.

Klebsiella pneumoniae is a leading cause of anti-microbial resistance in healthcare-associated infections that have posed a severe threat to neonatal and wider community. The escalating crises of antibiotic resistance have compelled researchers to explore an innovative arsenal beginning from natural resources to chemical modifications in order to overcome the ever-increasing resistance issues. The present review highlights the drug discovery efforts with a special focus on cutting-edge strategies in the hunt for potential drug candidates against MDR/XDR Klebsiella pneumoniae.

Machine Learning Prediction of Physicochemical Properties in Lithium-Ion Battery Electrolytes With Active Learning Applied to Graph Neural Networks.

Accurate prediction of physicochemical properties, such as electronic energy, enthalpy, free energy, and average vibrational frequencies, is critical for optimizing lithium-ion battery (LIB) performance. Traditional methods like density functional theory (DFT) are computationally expensive and inefficient for large-scale screening. In this study, we apply active learning on top of graph neural networks (GNNs) to efficiently predict these properties.

Drug release potential of polyacrylamide grafted-Assam Bora rice polysaccharide graft copolymer (ABRS-g-PAM) as effective controlled release polymer.

The research focuses on the characterization and evaluation of drug delivery efficiency of a microwave-assisted, free-radical synthesized polyacrylamide-grafted Assam Bora rice starch (ABRS) graft copolymer (ABRS-g-PAM). Percentage grafting efficiency (% GE) and intrinsic viscosity were chosen as the optimization parameters. The optimized ABRS-g-PAM Grade Formulation 4 (GF4) was found to be the best grade.

Efficacy of umbelliferone-loaded nanostructured lipid carrier in the management of bleomycin-induced idiopathic pulmonary fibrosis: experimental and network pharmacology insight.

Idiopathic pulmonary fibrosis (IPF) is a severe and progressive lung disorder with an average survival rate of 3 to 5 years. IPF presents a significant challenge in clinical management, necessitating novel therapeutic approaches. Nanostructured lipid carriers (NLCs) have proven to be promising vehicles for targeted drug delivery to the lung tissues.

Preeminent designing of complementary TRANSFER and COMPLEMENT alongside excitation modulated molecular logic systems.

This article describes an optically adjustable, dual complementary molecular TRANSFER and COMPLEMENT logic gate as well as an extremely rare design of excitation-modulated logic systems using a pyrene coupled bis(indolyl)methane derivative (1) in Brij-58 micelles, triggered by different chemical stimuli. We have looked into the optical response of the probe molecule towards variety of analytes, including OH, CN, Hg, EDTA ., at various excitation channels, in order to achieve this goal.

An overview of matrix metalloproteinase-12 in multiple disease conditions, potential selective inhibitors, and drug designing strategies.

Matrix metalloproteases (MMPs) are the proteolytic enzymes accountable for extracellular matrix (ECM) modification through their Zn-dependent catalytic activity. Among these, MMP-12 is one of the crucial MMPs that contributes to various disease states including different types of cancers and other major pathophysiological conditions including COPD, asthma, emphysema, skin diseases, arthritis, vascular diseases, and neurological disorders. The majority of the MMP-12 inhibitors should have three constitutional pharmacophoric features (i.

Derivatives of D(-)-glutamine-based MMP-2 inhibitors as an effective remedy for the management of chronic myeloid leukemia-Part-III: Synthesis, biological screening and in silico binding interaction analysis.

Tyrosine kinase inhibitors (TKIs) have markedly improved the overall survival rate of patients with chronic myeloid leukemia (CML), enabling them to achieve a normal life expectancy. However, toxicity, relapse, and drug resistance continue to pose major challenges in the clinical treatment of CML. The progression of leukemia is directly connected to higher expression levels and enzymatic actions of matrix metalloproteinase-2 (MMP-2).

Optimizing whole grain rice fortification using microwave-assisted screw conveying spraying and drying setup: Exploring solution absorption, gelatinization, and micronutrient retention.

This study presents a novel gelatinization-induced whole-grain rice fortification (GIWGRF) technology using a microwave-assisted screw conveying spraying and drying setup (MASCSD). The process involves microwave-assisted soaking of pregelatinized rice in a micronutrient solution, followed by steam-assisted gelatinization and drying. Rice with an initial degree of gelatinization (DG) of 58.

Inhibiting brushite crystal growth: molecular docking exploration of phytoconstituents and their interaction with human serum albumin.

In our preliminary studies, the extract demonstrated inhibition of calcium phosphate (brushite) crystals. Human serum albumin (HSA) is known to act as a promoter of brushite crystal growth. Therefore, the present study aims to explore the molecular mechanisms involved in brushite crystal nephrolithiasis by conducting molecular docking of phytoconstituents from with HSA.

Investigating CuO-ZrO Mixed Metal Oxide Nanocomposites for Electrochemical Sensing of Food Colors.

A fast and highly sensitive electrochemical sensor (ECS) is crucially desirable for observing synthetic dyes in foodstuffs, as excessive consumption of these colorants can pose risks to human health, including toxicity and pathogenicity. This research introduces the creation of an ECS comprising a CuO-ZrO nanocomposite for detecting Sunset Yellow (SY) dye in beverage and food items. The synthesized CuO-ZrO material underwent thorough characterization using various physicochemical and electroanalytical methods.

CLOCK gene 3'UTR and exon 9 polymorphisms show a strong association with essential hypertension in a North Indian population.

Background: Hypertension (HTN) is a medical condition characterized by persistent systolic and diastolic blood pressures of ≥ 140 mmHg and ≥ 90 mmHg, respectively. With more than 1200 million adult patients aged 30-79 years worldwide according to the latest WHO data, HTN is a major health risk factor; more importantly, 46% of patients are unaware of this condition. Essential hypertension (EH), also known as primary hypertension, is the predominant subtype and has a complex etiology that involves both genetic and non-genetic factors.

Transiting towards green productivity: Evidence from Indian organized manufacturing industries.

Promoting green growth and decarbonizing economies to achieve sustainable economic development has become critically important globally. This study calculated the energy-induced carbon emissions and green total factor productivity (GTFP) for the organized manufacturing sector in India utilizing factory-level Annual Survey of Industry datasets. The GTFP has been calculated utilizing the Global Malmquist-Luenberger index methodology at both the aggregate and industry levels.

Insights of Zinc Ion Storage in Chilli-Stem Derived Porous Carbon Enabling Ultrastability and High Energy Density of Zinc-Ion Hybrid Supercapacitors.

Aqueous zinc ion hybrid supercapacitors (ZIHSCs) are promising as low-cost and safe energy storage devices for next-generation applications. Still, their energy-power performance and durability are far from satisfactory. Here, we present an energy-dense, and ultrastable ZIHSC realized using activated porous carbons derived from chilli-stems.

Microsolvation-Driven Hours-Long Spectral Dynamics in Phenoxazine Dyes.

The phenoxazine class of dyes has found widespread applications in chemistry and biology for more than a century, particularly for lipid membrane studies. Here, we report a general phenomenon on the ensemble spectral stability of traditional phenoxazine class of dyes (nile red, cresyl violet, and nile blue) that exhibit hours-long microstructural transitions reflected through systematic changes of electronic spectra over an hour. Mechanistic investigations reveal that such spectral dynamics of the dyes can be mitigated by tuning microenvironments, where microsolvation plays an underlying role.

Anticancer and Cyclooxygenase Inhibitory Activity of Benzylidene Derivatives of Fenobam and its Thio Analogues.

Introduction: A series of benzylidene derivatives of fenobam and its thio analogues (1-22) have been evaluated for their cytotoxicity against breast cancer (MCF-7, MDA-MB-231), ovarian cancer (A2780, SKOV-3) and cervical cancer (HELA) cell lines.

Method: These compounds (1-22) exhibited 72-83% inhibition of Erk activity against the ovarian cancer cell line (A2780). Compounds 3 and 20 showed the highest DNA damage effect in Comet Assay against the A2780 cancer cell line as compared to the other tested analogues (4, 8, 11, 12, and 13) by using % Tail DNA and OTM.

Novel LCA-centric mix design approach for alkali-activated EAF slag with hybrid optimization techniques.

This study presents an innovative life cycle assessment (LCA)-centric approach for optimizing the mix design of alkali-activated materials (AAMs) as sustainable alternatives to ordinary portland cement (OPC). The AAMs are developed using electric arc furnace slag (EAFS) and fly ash as precursors. The environmental performance is evaluated using the ReCiPe midpoint methodology, considering both mass and economic allocation methods.

Novel isatin conjugates endowed with analgesic and anti-inflammatory properties: design, synthesis and biological evaluation.

Aims: This study aimed to develop novel molecular hybrid conjugates integrating isatin, rhodanine, and phthalimide pharmacophores to create effective analgesic and anti-inflammatory agents with improved safety profiles over existing treatments.

Materials & Methods: A series of hybrid conjugates () were synthesized and evaluated through in vitro and in vivo biological assays. The most promising compound, , underwent extensive pharmacological and toxicological evaluations.

Membrane-Bound Bisindolyl-Based Chromogenic Probes: Analysis of Cyanogenic Glycosides in Agricultural Crops for Possible Remediation.

Cyanogenic glycosides are plant-derived, nitrogen-containing secondary metabolites that release toxic cyanide ions upon hydrolysis by glycosidic enzymes. Therefore, consuming food items enriched with such compounds without proper remediation can cause acute cyanide intoxication. Thus, in this work, we utilize cyanide-responsive oxidized bisindole-based chromogenic probes to detect cyanogenic glycosides, such as amygdalin and linamarin (LOD: 0.

Regulation of the blood-brain barrier function by peripheral cues in health and disease.

The blood-brain barrier (BBB) is formed by microvascular endothelial cells which are ensembled with pericytes, astrocytes, microglia and neurons in the neurovascular unit (NVU) that is crucial for neuronal function. Given that the NVU and the BBB are highly dynamic and regulated structures, their integrity is continuously challenged by intrinsic and extrinsic factors. Herein, factors from peripheral organs such as gonadal and adrenal hormones may influence vascular function also in CNS endothelial cells in a sex- and age-dependent manner.

TBK1 Reprograms Metabolism in Breast Cancer: An Integrated Omics Approach.

Metabolic rewiring is required for cancer cells to survive in harsh microenvironments and is considered to be a hallmark of cancer. Specific metabolic adaptations are required for a tumor to become invasive and metastatic. Cell division and metabolism are inherently interconnected, and several cell cycle modulators directly regulate metabolism.

Discovery of novel hybrid tryptamine-rivastigmine molecules as potent AChE and BChE inhibitors exhibiting multifunctional properties for the management of Alzheimer's disease.

Contemporary research evidence has corroborated a gradual loss of central cholinergic neurons in Alzheimer's Disease (AD). This progressive deterioration leads to cognitive dysfunction and impaired motor activity, culminating in the brain cell's death in the disease. The approved drugs for AD treatment can only offer relief from symptoms without addressing the underlying pathological hallmarks of the disease.

Natural peptides and their synthetic congeners acting against through the membrane and cell wall: latest progress.

is one of the deadliest Gram-negative bacteria (GNB), responsible for 2-10% of hospital-acquired infections. Several antibiotics are used to control the growth of . However, in recent decades, the abuse and misuse of antibiotics to treat non-microbial diseases have led to the emergence of multidrug-resistant strains.