3 results match your criteria: "Biotec Centre[Affiliation]"
A robust liquid chromatographic mass spectrometric method capable of quantifying morphine, morphine 3-beta-D-glucuronide and morphine 6-beta-D-glucuronide down to 1.0 ng/ml, 5.0 ng/ml and 2.
View Article and Find Full Text PDFAn in vitro approach was undertaken to investigate the metabolite profile of dihydro-alpha-ergocryptine,9,10-[9,10 ( -3 ) H(N)] in humans by comparison with two species, rat and monkey, for toxicological studies. Hepatocytes (rat and human) and microsomes (rat, monkey, and human) were used in this study, and a high-performance liquid chromatography system was developed to determine the metabolic profiles. From the two in vitro metabolizing systems it was concluded that the compound was extensively metabolized in all species, with a similar overall rate of 4.
View Article and Find Full Text PDFSkin distribution of fipronil by microautoradiography following topical administration to the beagle dog.
Eur J Drug Metab Pharmacokinet
November 1997
Biotec Centre, Orleans, France.
Article Synopsis
- The study investigated how fipronil, a pesticide, spreads in dog skin after topical application, using a beagle to test it out.
- Results showed that fipronil primarily settled in the outer skin layers and sebaceous glands, staying there for up to 56 days.
- However, it didn’t penetrate deeper skin layers, indicating that fipronil has low absorption through the skin.