3 results match your criteria: "Bioscience Institute from Federal University of Mato Grosso do Sul[Affiliation]"
Interleukin-17 expression in the serum and exfoliated cervical cells of patients infected with high-risk oncogenic human papillomavirus.
Cytokine
August 2019
Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
Article Synopsis
- Persistent infection with high-risk HPV is a major cause of cervical cancer, and the immune response, particularly involving IL-17 and Th17 cells, plays a key role in managing infection.* -
- The study measured IL-17 levels in the serum and cervical cells of 26 HR-HPV-infected patients and 18 healthy individuals, finding significantly higher IL-17 concentrations in HR-HPV-positive patients.* -
- Despite higher systemic IL-17 levels in HR-HPV-infected patients, there were no significant differences in CD4IL-17 cell counts across various cervical lesions, indicating a more systemic than localized immune response.*
Self-Collection and Molecular Diagnosis for Detection of Human Papillomavirus: Why Incorporate It?
Curr Infect Dis Rep
March 2019
Bioscience Institute from Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Purpose Of Review: Cervical cancer, the third cause of death by cancer among Brazil's women, is associated with human papillomavirus (HPV) infection. In some countries of South America, North America, Europe, and Oceania, initial screening for HPV DNA and subsequent follow-up with HPV-positive patients using colposcopy and cytological testing are used as preventative measures.
Recent Findings: For HPV DNA detection, it is necessary to obtain cervical cells by conventional clinical collection method or self-collection of the cells that flake off from the uterine cervix and vaginal canal.
Detection of regulatory T cell phenotypic markers and cytokines in patients with human papillomavirus infection.
J Med Virol
February 2019
Laboratory of Immunology, Bioassays, and Molecular Biology, Bioscience Institute from Federal University of Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
Infection with human papillomavirus (HPV) is the main cause of cervical cancer. Viral persistence is considered the main risk factor for neoplastic progression and evidence suggests that regulatory T cells (Treg) play an important role in the failure of viral elimination. The aim of this study was to detect phenotypic markers of Treg and cytokines interleukin (IL)-10 and transforming growth factor (TGF)-β, in the cervical microenvironment of HPV-infected patients.
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