5 results match your criteria: "Bioscience Institute UNESP[Affiliation]"
The effect of the Mediterranean Diet on lifespan: a treatment-effect survival analysis of a population-based prospective cohort study in Southern Italy.
Int J Epidemiol
March 2021
Laboratory of Epidemiology and Biostatistics, National Institute of Gastroenterology 'S de Bellis' Research Hospital, Castellana, Grotte, (BA), Italy.
Background: The Mediterranean diet (MedDiet) is associated with good health. We aimed to estimate the effect of levels of adherence to the MedDiet on lifespan by performing treatment effects survival analysis.
Methods: A sample of 5250 subjects aged ≥18 years were randomly selected from the electoral list of Castellana Grotte and Putignano (Apulian Region, Italy).
Wortmannin targeting phosphatidylinositol 3-kinase suppresses angiogenic factors in shear-stressed endothelial cells.
J Cell Physiol
June 2020
Bioassays and Cell Dynamics Laboratory, Department of Chemistry and Biochemistry, Bioscience Institute UNESP, Botucatu, Sao Paulo, Brazil.
Modifications on shear stress-based mechanical forces are associated with pathophysiological susceptibility and their effect on endothelial cells (EC) needs to be better addressed looking for comprehending the cellular and molecular mechanisms. This prompted us to better evaluate the effects of shear stress in human primary venous EC obtained from the umbilical cord, using an in vitro model to mimic the laminar blood flow, reaching an intensity 1-4 Pa. First, our data shows there is a significant up-expression of phosphatidylinositol 3-kinase (PI3K) in shear-stressed cells culminating downstream with an up-phosphorylation of AKT and up-expression of MAPK-ERK, concomitant to a dynamic cytoskeleton rearrangement upon integrin subunits (α4 and ß 3) requirements.
View Article and Find Full Text PDFParticipation of TLR2 and TLR4 in Cytokines Production by Patients with Symptomatic and Asymptomatic Chronic Chagas Disease.
Scand J Immunol
January 2017
Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil.
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a serious public health issue. Its evolution involves an acute stage, characterized by no specific symptoms, and the chronic stage during most individuals are asymptomatic, but about 30-40% of them become symptomatic presenting the cardiac or digestive disease. Host immune response mechanisms involved in symptomatic or asymptomatic chronic disease are not fully understood.
View Article and Find Full Text PDFDetermination of the Mercury Fraction Linked to Protein of Muscle and Liver Tissue of Tucunaré (Cichla spp.) from the Amazon Region of Brazil.
Arch Environ Contam Toxicol
November 2015
Department of Chemistry and Biochemistry, Bioscience Institute - UNESP, São Paulo State University, Rubião Júnior, Botucatu, São Paulo, 18618-970, Brazil.
Article Synopsis
- This study investigated mercury-bound proteins in the muscle and liver of Tucunaré fish from Brazil using metalloproteomic techniques.
- Protein separation was achieved through fractional precipitation and 2-D polyacrylamide gel electrophoresis, with mercury quantified using atomic absorption spectrometry.
- Seven proteins with biomarker characteristics for mercury were identified, including parvalbumin and its isoforms, as well as ubiquitin-40S ribosomal protein, among others.
Obstacle stepping and body scale modulating parameters.
Percept Mot Skills
October 2009
Posture and Gait Studies Laboratory, Department of Physical Education-Bioscience Institute UNESP-São Paulo State University at Rio Claro, Brazil.
The purpose of this study was to investigate gait spatial parameters at the point of departure, with obstacle heights adjusted to individual body scale. Undergraduate student volunteers (M age = 22.4 yr.
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