2 results match your criteria: "Biomedical Research Institute (IIB Sant Pau) Sant Pau[Affiliation]"
Clinicopathological correlates in the frontotemporal lobar degeneration-motor neuron disease spectrum.
Brain
July 2024
Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute (IIB Sant Pau) Sant Pau, Barcelona 08025, Spain.
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a serious motor neuron disease that can also exhibit cognitive and behavioral symptoms, often overlapping with frontotemporal dementia (FTD) in some patients.
- * Around 50% of patients with motor neuron disease experience cognitive issues, with 10-15% meeting the criteria for FTD, emphasizing the need for better diagnostic tools.
- * A study analyzed data from 124 MND patients to understand the prevalence of FTD-related changes and identified specific clinical, genetic, and pathological subgroup characteristics, finding that 35.5% had features of frontotemporal lobar degeneration (FTLD).
Effects of storage conditions on the stability of blood-based markers for the diagnosis of Alzheimer's disease.
Clin Chem Lab Med
August 2023
Department of Biochemistry, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, Barcelona, Spain.
Objectives: Alzheimer's disease (AD) is considered the most common cause of dementia in older people. Recently, blood-based markers (BBM) Aβ1-42, Aβ1-40, and phospho Tau181 (p-Tau181) have demonstrated the potential to transform the diagnosis and prognostic assessment of AD. Our aim was to investigate the effect of different storage conditions on the quantification of these BBM and to evaluate the interchangeability of plasma and serum samples.
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