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Coupling-induced complexity in nephron models of renal blood flow regulation.
Am J Physiol Regul Integr Comp Physiol
April 2010
Department of Molecular Pharmacology, Brown University, Biomedical Center B-3, Providence, RI 02912, USA.
Tubular pressure and nephron blood flow time series display two interacting oscillations in rats with normal blood pressure. Tubuloglomerular feedback (TGF) senses NaCl concentration in tubular fluid at the macula densa, adjusts vascular resistance of the nephron's afferent arteriole, and generates the slower, larger-amplitude oscillations (0.02-0.
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