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Biocruces Bizkaia Health Research Insti... Publications | LitMetric

1,326 results match your criteria: "Biocruces Bizkaia Health Research Institute[Affiliation]"

Background: Despite evidence suggesting that age moderates the response to preventative treatment for those at clinical high risk of psychosis (CHR-P), no meta-analysis has assessed the effectiveness of preventative interventions for CHR-P children and adolescents. Our aim was to synthesise evidence assessing preventative interventions on a wide range of mental health outcomes for CHR-P children and adolescents.

Method: A systematic search was conducted on Ovid MEDLINE, Pubmed, APA PsycInfo and Web of Science until June 2024 (PROSPERO: CRD42023406696).

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Even though gene duplication is a key source of new genes and evolutionary innovation, it is unclear how duplicates survive the period immediately following gene duplication, in which both copies are functionally redundant. In the absence of epigenetic silencing, the abundance of the gene product would double after gene duplication, which would often have deleterious effects. However, recent duplicates exhibit low expression levels, which could be at least partially explained by high levels of promoter methylation.

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Stage 1 Extensive Macular Atrophy with Pseudodrusen-Like Appearance Complicated by Multiple Evanescent White Dot Syndrome-Like Reaction.

Ocul Immunol Inflamm

December 2024

Harvard Retinal Imaging Lab, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Purpose: To describe a case of early-stage Extensive Macular Atrophy with Pseudodrusen-like appearance (EMAP) presenting with acute monocular loss and atypical retinal lesions suggestive of posterior uveitis.

Methods: Case report with longitudinal follow-up including visual field testing and multimodal imaging.

Results: A 53-year-old woman presented with sudden vision loss in her right eye (RE).

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Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials.

Lancet

December 2025

Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain. Electronic address:

Background: Allogeneic haematopoietic stem-cell transplantation is the standard treatment for bone marrow failure (BMF) in patients with Fanconi anaemia, but transplantation-associated complications such as an increased incidence of subsequent cancer are frequent. The aim of this study was to evaluate the safety and efficacy of the infusion of autologous gene-corrected haematopoietic stem cells as an alternative therapy for these patients.

Methods: This was an open-label, investigator-initiated phase 1/2 clinical trial (FANCOLEN-1) and long-term follow-up trial (up to 7 years post-treatment) in Spain.

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Sarcopenia is linked to the decline in muscle mass, strength and function during aging. It affects the quality and life expectancy and can lead to dependence. The biological process underlying sarcopenia is unclear, but the proteins myostatin and follistatin are involved in the balance between muscle breakdown and synthesis.

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Neuroblastoma (NB) is the most common extracranial solid cancer in children. Despite intensive multimodality treatment, long-term survival of patients with high-risk NB, which comprises more than half of all cases, remains poor. Nuclear medicine is key in diagnosis, staging, response assessment and long-term follow-up of NB.

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Eggerthella lenta is an obligate anaerobic, Gram-positive bacilli, belonging to the human microbiota of gastrointestinal and female reproductive tracts, oral cavity and prostate gland. In this article, we aim to describe clinical and microbiological characteristics of seven E. lenta strains causing bacteremia.

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Exploring the reactivity of bicyclic α-iminophosphonates to access new imidazoline I receptor ligands.

Bioorg Chem

October 2023

Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain. Electronic address:

Recent studies pointed out the modulation of imidazoline I receptors (I-IR) by selective ligands as a putative strategy to face neurodegenerative diseases. Foregoing the classical 2-imidazoline/imidazole-containing I-IR ligands, we report a family of bicyclic α-iminophosphonates endowed with high affinity and selectivity upon I-IR and we advanced a representative compound B06 in preclinical phases. In this paper, we describe the synthetic possibilities of bicyclic α-iminophosphonates by exploring its ambivalent reactivity, leading to unprecedented molecules that showed promising activities as I-IR ligands in human brain tissues and good BBB permeation capabilities.

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Background And Aims: Inflammatory pouch disorders exhibit a heterogeneous clinical spectrum and therapeutic requirements have not been properly studied.

Methods: This retrospective, multicentre study included ulcerative colitis patients with ileal pouch construction and were later diagnosed with an inflammatory pouch disorder between 1995 and 2020. Classifications, behaviour and therapies applied were recorded and compared in the long-term.

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ANA-positive versus ANA-negative Antiphospholipid Antibody-positive Patients: Results from the APS ACTION Clinical Database and Repository.

Rheumatology (Oxford)

October 2024

University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital, Turin, Italy.

Article Synopsis
  • - This study examined the occurrence and effects of antinuclear antibodies (ANA) in patients with antiphospholipid antibodies (aPL) but without other systemic autoimmune diseases, using data from the APS ACTION Registry.
  • - Among the 430 analyzed patients, 56% tested positive for ANA, revealing significant links between ANA positivity and various autoimmune features like hematologic issues and joint involvement.
  • - Despite the presence of these autoimmune characteristics in ANA-positive patients, the study found no connection between ANA status and complications related to thrombosis or pregnancy; interestingly, ANA-negative patients had more pregnancies and live births.
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Article Synopsis
  • Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature newborns, with treatment focusing on supportive care rather than a cure.
  • This study examined the effects of a new glucocorticoid, ciclesonide, on lung health and brain effects in a rat model of BPD induced by chorioamnionitis.
  • Results showed that ciclesonide treatment improved lung function and structure and reduced pulmonary hypertension without negatively impacting brain development.
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Background And Purpose: Centers for training in autonomic nervous system (ANS) disorders are not widely available and the recent coronavirus 2019 pandemic temporarily reduced training opportunities in autonomic medicine across European countries. Here we evaluated the current state of education, clinical skills and postgraduate educational preferences on ANS disorders of European neurology residents and consultants.

Methods: A 23-item questionnaire was developed and distributed online amongst European neurology residents and consultants via mailing lists of the European Academy of Neurology.

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Article Synopsis
  • The aging brain's cognitive abilities are influenced by a balance between protective lifestyles and the accumulation of brain pathologies, especially in Alzheimer's disease.
  • A study involving 440 participants used advanced methods to analyze the relationships between physical activity, cognitive function, and specific brain changes after death.
  • Key findings revealed that synaptic peptides are critical for understanding cognitive decline, with lower physical activity linked to greater negative impacts between tau pathology and synaptic health in older adults.
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Article Synopsis
  • The integration of sex and gender in research is essential for valid data, especially in studying the mental health of hospital staff during the COVID-19 pandemic, but the extent of gender sensitivity in these studies is unclear.
  • A scoping review was conducted reviewing studies from various databases to evaluate the mental health of hospital staff, using specific psychometric scales and a developed gender sensitivity assessment tool.
  • Out of 3,112 identified studies, only 72 met the criteria, with most being cross-sectional; however, a significant majority mishandled the concepts of sex and gender, and only one study adequately addressed gender in their findings.
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Aggressive B-cell non-Hodgkin lymphomas (NHL) in children, adolescents, and young adults (CAYA) include Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and a subset of high-grade tumors with features intermediate between these entities whose genetic and molecular profiles have not been completely elucidated. In this study, we have characterized 37 aggressive B-NHL in CAYA, 33 with high-grade morphology, and 4 DLBCL with MYC rearrangement (MYC-R), using targeted next-generation sequencing and the aggressive lymphoma gene expression germinal center B-cell-like (GCB), activated B-cell-like (ABC), and dark zone signatures (DZsig). Twenty-two tumors had MYC-R without BCL2 breaks, and two MYC-non-R cases had BCL6 translocations.

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Experimental models as a tool for research on sarcopenia: A narrative review.

Ageing Res Rev

November 2024

Physiology Department, Faculty of Medicine and Nursery, University of the Basque Country (UPV/EHU), Barrio Sarriena, sn., Leioa 48940,  Spain; Biocruces Bizkaia Health Research Institute, Barakaldo, Bizkaia 48903, Spain. Electronic address:

Sarcopenia is a musculoskeletal disorder related to muscle mass and function; as the worldwide population ages, its growing prevalence means a decline in quality of life and an increased burden for public health systems. As sarcopenia is a reversible condition, its early diagnosis is of utmost importance. Consensus definitions and diagnosis protocols for sarcopenia have been evolving for a long time, and the identification of molecular pathways subjacent to sarcopenia is a growing research area.

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Article Synopsis
  • Dry eye disease (DED) may be associated with axial spondylarthritis (axial-SpA), as this study aims to investigate the correlation between the two conditions and identify related variables.
  • Out of 71 axial-SpA patients, 64.8% reported DED symptoms compared to only 15.8% of 19 healthy controls, suggesting a significantly higher prevalence of DED in axial-SpA patients.
  • Various ocular tests revealed that axial-SpA patients exhibited poorer tear production and ocular surface health, indicated by lower Schirmer test scores, shorter tear break-up times, and higher staining levels, reinforcing the link between axial-SpA and DED.
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Introduction: Antimalarials (AMs) are old drugs with a wide range of beneficial effects in systemic lupus erythematosus (SLE) beyond the control of activity. The most recent debate is focused on defining the optimal doses to assure the best benefit/risk ratio.

Areas Covered: We have reviewed the pharmacological basis underlying the various therapeutic effects of AMs and the beneficial and toxic effects of HCQ, also discussing the role of mepacrine not only as a substitute in cases of maculopathy, but also as a very effective therapy combined with HCQ.

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Article Synopsis
  • A recent study evaluated the prevalence of potentially inappropriate medications (PIM) in hospitalized adults aged 75 and older across 16 hospitals in Spain.
  • The study included 4,183 patients and found that 23.5% were prescribed PIMs, with a notable variation in prevalence between hospitals (10% to 42.5%).
  • Benzodiazepines were the most common PIMs, and many patients continued their PIMs from pre-admission into the hospital; however, few were still prescribed at discharge, highlighting the need for better medication management for older adults.
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Article Synopsis
  • The article discusses corrections to research findings initially published.
  • It emphasizes the importance of accuracy in scientific communication.
  • This correction aims to ensure that readers are aware of any significant changes to the original data and conclusions.
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Empowering the future of psychiatry: The development of the young psychiatrists section of the Spanish Society of Psychiatry and Mental Health.

Span J Psychiatry Ment Health

September 2024

Adult Psychiatry Outpatient Clinic, Fundació Pere Mata Terres de l'Ebre, Amposta, Tarragona, Spain; Department of Medicine, School of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Psychiatry, School of Medicine, University of Panama, Panama City, Panama; Center of Population Sciences for Health Equity, College of Nursing, Florida State University, Tallahassee, FL, USA.

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Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke.

Stroke

October 2024

Stroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau, Barcelona, Spain (J.C.-M., E.M., C.G.-F., N.C., M.L., L.L.-C., J.M.M.-C., I.F.-C.).

Background: Ischemic stroke (IS) represents a significant health burden globally, necessitating a better understanding of its genetic underpinnings to improve prevention and treatment strategies. Despite advances in IS genetics, studies focusing on the Spanish population and sex-stratified analyses are lacking.

Methods: A case-control genome-wide association study was conducted with 9081 individuals (3493 IS cases and 5588 healthy controls).

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