Phytochemical Composition, Antibacterial Activity, and Antioxidant Properties of the Fruits to Promote Their Consumption in the Comoros Islands as Potential Health-Promoting Food or a Source of Bioactive Molecules for the Food Industry.

The present study aimed to evaluate the health-promoting potential of breadfruit ( (Parkinson) Fosberg, Moraceae family), a traditional Comorian food, considering the sample variability according to geographic localisation. Moreover, the main aims of this research were also to promote its consumption in the Comoros Islands as potential health-promoting food and evaluate it as a source of bioactive molecules for the food industry thanks to its antioxidant and antibacterial properties. Investigations on biologically active substances were carried out on the extracts obtained from breadfruit flours from five regions of Grande Comore (Ngazidja), the main island in Comoros.

Isolation and Biological Characterization of Homoisoflavanoids and the Alkylamide --Coumaroyltyramine from Rottb., an Amaryllidaceae Species Collected in Senegal.

Rottb. (syn. ) is an Amaryllidaceae plant used in African traditional medicine but very few studies have been performed on this species from a chemical and applicative point of view.

sRNA Profiler: A User-Focused Interface for Small RNA Mapping and Profiling.

Viroids are circular, highly structured, single-stranded, non-coding RNA pathogens known to infect and cause disease in several plant species. They are known to trigger the host plant's RNA silencing machinery. The detection of viroid-derived small RNAs (vd-sRNA) in viroid-infected host plants opened a new avenue of study in host-viroid pathogenicity.

Sonoelastography of the Shoulder: A Narrative Review.

Sonoelastography is a relatively new non-invasive imaging tool to assess the qualitative and quantitative biomechanical properties of various tissues. Two types of sonoelastography (SE) are commonly explored: strain and shear wave. Sonoelastography can be used in multiple medical subspecialties to assess pathological tissular changes by obtaining mechanical properties, shear wave speed, and strain ratio data.

Biological treatment of saline domestic wastewater by using a down-flow hanging sponge reactor.

In this study, the effect of salinity on the removal of organic matter and nitrogen concentrations in bioreactor was investigated using a hybrid bench scale down-flow hanging sponge (DHS) system for 145 days of operation. The reactor had three identical sections that were filled to 30% volume with Bio-Bact to serve as attached media. The DHS reactor was fed with domestic wastewater that was mixed with increasing concentration of sodium chloride from 0.

Information-theoretic measures of superconductivity in a two-dimensional doped Mott insulator.

A key open issue in condensed-matter physics is how quantum and classical correlations emerge in an unconventional superconductor from the underlying normal state. We study this problem in a doped Mott insulator with information-theory tools on the two-dimensional (2D) Hubbard model at finite temperature with cluster dynamical mean-field theory. We find that the local entropy detects the superconducting state and that the difference in the local entropy between the superconducting and normal states follows the same difference in the potential energy.

Biorefinery potential of sustainable municipal wastewater treatment using fast-growing willow.

The use of willow plantations can be a sustainable approach for treating primary municipal wastewater, potentially reducing both the environmental and economic burdens associated with conventional treatment. However, the impact of wastewater irrigation upon the willow biorefinery potential has not yet been established. To investigate this effect, three-year-old field grown willows were harvested from plots kept as either controls or irrigated with primary municipal wastewater effluent at 29.

Musculoskeletal ultrasound for 3D bone modeling: A preliminary study applied to lumbar vertebra.

Background: There is no non-invasive in vivo method to assess intervertebral kinematics. Current kinematics models are based on in vitro bone reconstructions from computed tomography (CT)-scan imaging, fluoroscopy and MRIs, which are either expensive or deleterious for human tissues. Musculoskeletal ultrasound is an accessible, easy to use and cost-effective device that allows high-resolution, real-time imaging of bone structure.

Flexible and porous 2D layered structures based on mixed-linker metal-organic frameworks for gas sorption studies.

Layered structures of flexible mixed-linker metal-organic frameworks termed IRHs-(4 and 5) (IRH = Institut de Recherche sur l'Hydrogène) were synthesized by mixing cyclam, tetrakis(4-carboxyphenyl)benzene (TCPB), and copper and zinc metal salts respectively. The new materials characterized by single-crystal X-ray diffraction exhibited the features of HOFs and MOFs. Their structures are formed by coordination and hydrogen bonds that link metallocyclam (with Cu or Zn) and TCPB to a 2D sheet which is further packed to form a 3D structure with 1D microchannels.

Effects of radiation and role of plants in radioprotection: A critical review.

Radiation can be lethal at high doses, whereas controlled doses are useful in medical applications. Other applications include power generation, agriculture sterilization, nuclear weapons, and archeology. Radiation damages genetic material, which is reflected in genotoxicity and can cause hereditary damage.

Mechanistic Insights on Heme-to-Heme Transmembrane Electron Transfer Within NADPH Oxydases From Atomistic Simulations.

NOX5 is a member of the NADPH oxidase family which is dedicated to the production of reactive oxygen species. The molecular mechanisms governing transmembrane electron transfer (ET) that permits to shuttle electrons over the biological membrane have remained elusive for a long time. Using computer simulations, we report conformational dynamics of NOX5 embedded within a realistic membrane environment.

Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4.

The synthesis of two isomeric testosterone dimers and an androstenedione dimer is reported. The design takes advantage of an efficient transformation of testosterone leading to the synthesis of the key diene, 7α-(buta-1,3-dienyl)-4-androsten-17β-ol-3-one, through an elimination reaction. It was found that in some instances the same reaction led to partial epimerization of the 17β-hydroxyl group into the 17α-hydroxyl group.

Detecting volatile organic compounds to locate human remains in a simulated collapsed building.

The occurrence of mass disasters has increased worldwide due to changing environments from global warming and a heightened threat of terrorism acts. When these disasters strike, it is imperative to rapidly locate and recover human victims, both the living and deceased. While search and rescue dogs are used to locate the living, cadaver detection dogs are typically tasked with locating the dead.

Editorial for the Special Issue: Functional Polymer Composites.

Functional polymer composites are now making significant strides in synthesis, design, preparation, processing, and promising applications [...

New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.

C407 is a compound that corrects the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein carrying the p.Phe508del (F508del) mutation. We investigated the corrector effect of c407 and its derivatives on F508del-CFTR protein.

Calcium-dependent protein kinase 2 plays a positive role in the salt stress response in potato.

StCDPK2 is an early player in the salt stress response in potato plants; its overexpression promoted ROS scavenging, chlorophyll stability, and the induction of stress-responsive genes conferring tolerance to salinity. The salinity of soils affects plant development and is responsible for great losses in crop yields. Calcium-dependent protein kinases (CDPKs) are sensor-transducers that decode Ca signatures triggered by abiotic stimuli and translate them into physiological responses.

,'-Bis[2,6-bis-(1-methyl-eth-yl)phen-yl]pyridine-4-carboximidamide toluene hemisolvate.

The title compound, CHN·0.5CH, is a symmetrically ,'-disubstituted aryl-amidine containing a 4-pyridyl substituent on the carbon atom of the N-C-N linkage and bulky 2,6-diiso-propyl-phenyl groups on the nitro-gen atoms. It crystallizes in the configuration and its amidine C-N bonds present amine [1.

Mutations in the coordination spheres of T1 Cu affect Cu-activation of the laccase from Thermus thermophilus.

Thermus thermophilus laccase belongs to the sub-class of multicopper oxidases that is activated by the extra binding of copper to a methionine-rich domain allowing an electron pathway from the substrate to the conventional first electron acceptor, the T1 Cu. In this work, two key amino acid residues in the 1st and 2nd coordination spheres of T1 Cu are mutated in view of tuning their redox potential and investigating their influence on copper-related activity. Evolution of the kinetic parameters after copper addition highlights that both mutations play a key role influencing the enzymatic activity in distinct unexpected ways.

Efficient SARS-CoV-2 detection in unextracted oro-nasopharyngeal specimens by rRT-PCR with the Seegene Allplex™ 2019-nCoV assay.

Background: The fight against the COVID-19 pandemic has created an urgent need to rapidly detect infected people. The challenge for clinical laboratories has been finding a high throughput, cost-efficient, and accurate testing method in the context of extraction reagents shortage on a global scale. To answer this need, we studied SARS-CoV-2 detection in oro-nasopharyngeal (ONP) swabs stored in Universal Transport Media (UTM) or in RNase-free water by rRT-PCR with Seegene Allplex™ 2019-nCoV assay without RNA extraction.

Detecting grave sites from surface anomalies: A longitudinal study in an Australian woodland.

Forensic investigations of single and mass graves often use surface anomalies, including changes to soil and vegetation conditions, to identify potential grave locations. Though numerous resources describe surface anomalies in grave detection, few studies formally investigate the rate at which the surface anomalies return to a natural state; hence, the period the grave is detectable to observers. Understanding these processes can provide guidance as to when ground searches will be an effective strategy for locating graves.

A Rational Design of Microporous Nitrogen-Rich Lanthanide Metal-Organic Frameworks for CO/CH Separation.

Three new lanthanide metal-organic frameworks IRHs-() supported by cyamelurate linkers have been synthesized and structurally characterized. The incorporation of numerous heteroatoms (N and O) into the pore walls and the relatively small microchannels of these porous solids enhance bonding force of the host-guest interactions, thus promoting the adsorption of carbon dioxide (CO) over methane (CH). The nonpolar covalent bonds in methane also favor the less uptake due to the hydrophilic walls of these frameworks.

Perspectives on the establishment of a canadian human taphonomic facility: The experience of REST[ES].

REST[ES] is the first Canadian human taphonomic facility (HTF) dedicated to research and training relating to human decomposition in a northern temperate climate. The following paper outlines the measures taken to successfully establish, open and operate this novel Canadian HTF with particular focus on: project team and partnerships, facility location, approvals and permits, infrastructure and social acceptability. It is intended that our experience of establishing REST[ES] may serve as an example to help others with the establishment of future HTFs, thus contributing to the expansion in the global accessibility to human decomposition research and training.