70 results match your criteria: "Binhaiwan Central Hospital of Dongguan[Affiliation]"

Background And Objective: Basal cell carcinoma (BCC) is the most common malignancy of humankind, characterized by its low propensity for metastasis and its high recurrence rate. Surgical intervention is the predominant therapeutic approach. However, for cases of locally advanced BCC (laBCC) and metastatic BCC (mBCC), systematic therapy may be the first option.

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Diabetic cardiomyopathy (DCM) is pathologically characterized by excessive deposition of extracellular matrix proteins, leading to myocardial fibrosis. Fibromodulin (Fmod) plays a crucial role in the pathogenesis of fibrotic diseases. However, the role and mechanism of Fmod in DCM-related myocardial fibrosis remain unclear.

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Preventing the progression of acute pancreatitis (AP) to severe acute pancreatitis (SAP) is crucial for AP patients. The use of clinical parameters in laboratory facilities for predicting SAP can be rapid, efficient, and cost-effective. This study aimed to investigate the predictive and prognostic value of collected clinical detection parameters, such as serum alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) levels, and their ratios, such as ALP-to-hemoglobin (Hb) and LDH-to-Hb ratios, for the prediction of SAP occurrence, complications, and mortality.

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Introduction: Our study endeavours to ascertain the plasma-derived long noncoding ribonucleic acids (lncRNA) and messenger RNA (mRNA) expression profiles through gene microarray analysis, aiming to elucidate their potential biological roles in the development and progression of diabetic cardiomyopathy (DCM), particularly with respect to myocardial fibrosis.

Material And Methods: We conducted gene chip experiments to discern differences in lncRNA and mRNA expression profiles between diabetic cardiomyopathy and type 2 diabetes mellitus (T2DM). Differentially expressed mRNAs were subjected to functional enrichment analysis, thereby enabling the identification of key genes.

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Inhibitory Effect of CMU-Pb-L5 In a Subcutaneous Transplanted Tumor Model of Colorectal Cancer.

Int J Med Sci

October 2024

Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.

() is a prevalent probiotic strain within the genus, which has robust intestinal colonization capabilities. Previous studies have demonstrated the anticancer properties of both and . However, the mechanisms underlying its anticancer activity remain unclear.

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The author replies-sample size issue and overfitting.

Am J Emerg Med

December 2024

Department of Intensive Care Medicine, Binhaiwan Central Hospital of Dongguan, Guangdong Province, China; The Key Laboratory for Prevention and Treatment of Critical Illness in Dongguan City, Guangdong Province, China. Electronic address:

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Article Synopsis
  • Recent cancer treatment strategies have shown improved efficacy but also lead to complex adverse effects, as evidenced by a case involving a 67-year-old male with gastric stump carcinoma.
  • The patient experienced severe symptoms including chills, high fever, and shock following treatment with a combination of chemotherapy and a PD-1 inhibitor, initially misdiagnosed as immune-related adverse events or a bacterial infection.
  • Ultimately, it was determined that a rare hypersensitivity reaction to oxaliplatin was the real cause of the patient's severe organ damage, highlighting the challenges in accurately diagnosing adverse events related to cancer treatments.
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The direct antitumor effect of bevacizumab (BEV) has long been debated. Evidence of the direct antitumor activities of drugs are mainly obtained from in vitro experiments, which are greatly affected by experimental conditions. In this study, we evaluated the effect of BEV-containing medium renewal on the results of in vitro cytotoxicity experiments in A549 and U251 cancer cells.

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isolated from pleural effusion: A case report.

World J Clin Cases

June 2024

Department of Laboratory Science, Binhaiwan Central Hospital of Dongguan, Dongguan 523905, Guangdong Province, China.

Article Synopsis
  • - The text discusses a rare gram-negative bacterium known for its corrosive and pathogenic characteristics, which can inhabit the oral, nasopharyngeal, gastrointestinal, and urogenital regions in humans and animals, but is challenging to diagnose due to slow growth and uneven hospital resources in China.
  • - A case study involving a 67-year-old male patient is highlighted, who presented with symptoms like cough and dyspnea, leading to the discovery of empyema and a correlation with the aforementioned bacterium.
  • - Despite receiving antimicrobial treatment, the patient unfortunately passed away after 22 days in the hospital, underscoring the severity of infections associated with this specific bacterium.
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Clusterin attenuates blood-brain barrier damage and cognitive impairment by inhibiting astrocyte aging in mice with sepsis-associated encephalopathy.

Neuroreport

September 2024

Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Sepsis-associated encephalopathy (SAE) is a severe complication of sepsis, however, its exact mechanism remains unknown. This study aimed to evaluate whether clusterin is essential to the development of SAE during the aging process of astrocytes. In the study, septic mice were established with cecal ligation and puncture (CLP) and lipopolysaccharides were applied to astrocytes in vitro.

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The intricate processes that govern the interactions between peripatetic immune cells and distal renal injury in obesity are not fully understood. Employing transcriptomic analysis of circulating extracellular vesicles (EVs), a marked amplification of small RNA (miR-3960) is discerned within CD3CD19 B cells. This RNA is found to be preferentially augmented in kidney tissues, contrasting with its subdued expression in other organs.

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Hyperglycemia induces microglial pyroptosis by increasing oxygen extraction rate: Implication in neurological impairment during ischemic stroke.

Mol Med Rep

August 2024

Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, P.R. China.

Elevated levels of blood glucose in patients with ischemic stroke are associated with a worse prognosis. The present study aimed to explore whether hyperglycemia promotes microglial pyroptosis by increasing the oxygen extraction rate in an acute ischemic stroke model. C57BL/6 mice that underwent middle cerebral artery occlusion were used for assessment of blood glucose level and neurological function.

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Vascular endothelium, a promising target for effectively treating fulminant diquat intoxication?

World J Clin Cases

June 2024

Department of Critical Care Medicine, Dongguan Eastern Central Hospital, Dongguan 523576, Guangdong Province, China.

Article Synopsis
  • Following the withdrawal of paraquat, diquat (DQ) has become the main herbicide, but it poses serious risks, including a poisoning mortality rate of up to 50%.
  • DQ poisoning can range from mild to fulminant, the latter often leading to multiple organ failure within 48 hours, complicating clinical treatment.
  • Research indicates that DQ may damage endothelial cells (EC), which are crucial for blood circulation in sensitive organs, and the authors suggest this EC damage could be a key factor in the severe organ failure associated with DQ poisoning.
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Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer.

Int J Med Sci

May 2024

Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, 523808, China.

Transforming growth factor-β (TGF-β) is strongly associated with the cell adhesion signaling pathway in cell differentiation, migration, etc. Mechanistically, TGF-β is secreted in an inactive form and localizes to the extracellular matrix (ECM) via the latent TGF-β binding protein (LTBP). However, it is the release of mature TGF-β that is essential for the activation of the TGF-β signaling pathway.

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Article Synopsis
  • Biliary infections are common and can cause serious health problems, so it's important to understand the bacteria responsible and how they resist antibiotics.
  • The study analyzed 3,490 bacterial samples from patients to see how many were resistant to certain drugs and to find risk factors for these infections.
  • The results showed that most bacteria were Gram-negative, and over time, some bacteria became more resistant to certain antibiotics while others became less resistant.
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Heat stress induces IL-1β and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke.

Neuroreport

June 2024

Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou.

Heat stroke induced cerebral damage via neuroinflammation. This study aimed to approach whether heat stress would promote NOD-like receptor protein 3 (NLRP3) inflammasome via reactive oxygen species (ROS). The mice were randomly divided into the sham group, the heat stress group, and the heat stress + TEMPOL (ROS scavenger) group.

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Dysregulation of cellular metabolism is a key marker of cancer, and it is suggested that metabolism should be considered as a targeted weakness of colorectal cancer. Increased polyamine metabolism is a common metabolic change in tumors. Thus, targeting polyamine metabolism for anticancer therapy, particularly polyamine blockade therapy, has gradually become a hot topic.

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Pathogenic factors of maxillary sinus mucosal thickening observed by cone-beam computed tomography (CBCT).

Appl Radiat Isot

June 2024

Department of Periodontics and Implantology, Stomatological Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, People's Republic of China. Electronic address:

Objective: To explore the pathogenic factors associated with maxillary sinus mucosal thickening with Cone-beam computed Tomography (CBCT).

Methods: From 2016 through 2020, 93 patients with periapical periodontitis or periodontitis in the maxillary posterior dental region were selected.

Results: The preoperative thickness of the periodontitis group was significantly higher than that of the periapical periodontitis group (P < 0.

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Robust positive association between serum urate and the risk of chronic obstructive pulmonary disease: hospital-based cohort and Mendelian randomisation study.

BMJ Open Respir Res

March 2024

The Key Laboratory of Advanced Interdisciplinary Studies, The First Affiliated Hospital, The Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong, China

Background: Chronic obstructive pulmonary disease (COPD) and hyperuricaemia are both characterised by systemic inflammation. Preventing chronic diseases among the population with common metabolic abnormality is an effective strategy. However, the association of hyperuricaemia with the higher incidence and risk of COPD remains controversial.

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Development of prognostic models for predicting 90-day neurological function and mortality after cardiac arrest.

Am J Emerg Med

May 2024

Department of Intensive Care Medicine, Binhaiwan Central Hospital of Dongguan, Guangdong Province, China; The Key Laboratory for Prevention and Treatment of Critical Illness in Dongguan City, Guangdong Province, China. Electronic address:

Background: The survivors of cardiac arrest experienced vary extent of hypoxic ischemic brain injury causing mortality and long-term neurologic disability. However, there is still a need to develop robust and reliable prognostic models that can accurately predict these outcomes.

Objectives: To establish reliable models for predicting 90-day neurological function and mortality in adult ICU patients recovering from cardiac arrest.

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Article Synopsis
  • The study looked at how being overweight around the stomach (abdominal obesity) might be connected to type 2 diabetes.
  • It involved a large group of over 232,000 adults in China and measured a substance called adiponectin in their blood.
  • The research found that people with belly fat had lower levels of adiponectin, and this lower level was linked to a higher risk of developing type 2 diabetes.
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Stress hyperglycemia increases short-term mortality in acute ischemic stroke patients after mechanical thrombectomy.

Diabetol Metab Syndr

January 2024

Department of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, 613 Huangpu Avenue west, Guangzhou, China.

Background And Purpose: Glucose-to-glycated hemoglobin ratio (GAR) is considered a more reliable marker of stress hyperglycemia by correcting for basal blood glucose levels. This study aimed to investigate the extent to which GAR is associated with 3 month and 1 year all-cause mortalities in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT).

Methods: We retrospectively followed 553 AIS patients who underwent MT.

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Rationale: Vascular complications associated with extracorporeal membrane oxygenation (ECMO) increase the in-hospital mortality. Perforation of the inferior vena cava (IVC) during venovenous extracorporeal membrane oxygenation (V-V ECMO) cannulation and subsequent emergency management prior to vascular surgery has rarely been reported.

Patient Concerns: A 72-year-old female was diagnosed with IVC perforation caused by venovenous extracorporeal membrane oxygenation cannulation.

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Heat stroke is a life-threatening disease with high mortality and complications. Endothelial glycocalyx (EGCX) is essential for maintaining endothelial cell structure and function as well as preventing the adhesion of inflammatory cells. Potential relationship that underlies the imbalance in inflammation and coagulation remains elusive.

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The impact of vascular endothelial glycocalyx on the pathogenesis and treatment of disseminated intravascular coagulation.

Blood Coagul Fibrinolysis

December 2023

Department of Intensive Care Medicine, Binhaiwan Central Hospital of Dongguan, Dongguan City, Guangdong Province, China.

Disseminated intravascular coagulation (DIC) is a complex disorder characterized by widespread activation of blood clotting mechanisms throughout the body. Understanding the role of vascular endothelial glycocalyx in the pathogenesis and treatment of DIC is crucial for advancing our knowledge in this field. The vascular endothelial glycocalyx is a gel-like layer that coats the inner surface of blood vessels.

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