Fusion of the occipitomastoidal synchondrosis as a developmental marker in the Sima de los Huesos Crania (Atapuerca, Spain).

The basicranium contains multiple synchondroses potentially informative for estimating the developmental stage of individuals. The basilar synchondrosis has been routinely used for this purpose in bioarchaeological, forensic and paleoanthropological research, and studies carried out in modern human populations have shown a close relationship between the fusion of the occipitomastoidal synchondrosis and developmental processes. This synchondrosis articulates the jugular process of the occipital bone with the jugular surface of the temporal bone.

Interspecies Scaling of Transgene Products for Viral Vector Gene Therapies: Method Assessment Using Data from Eleven Viral Vectors.

The prediction of transgene product expression in human is important to guide first-in-human (FIH) dose selection for viral vector-based gene replacement therapies. Recently, allometric scaling from preclinical data and interspecies normalization of dose-response (D-R) relationship have been used to predict human transgene product expression of adeno-associated virus (AAV) vectors. In this study, we assessed two interspecies allometric scaling methods and two dose-response methods in predicting human transgene product expression of nine intravenously administered AAV vectors, one intramuscularly administered AAV vector, and one intravesical administered adenoviral vector.

Resilience, Coping, and the Covid-19 Pandemic Across the Globe - an Update: What Have we Learned?

The SARS-CoV-2 (COVID-19) pandemic is a mass traumatic event that has universally and indiscriminately negatively affected the world. The adverse consequences of the pandemic have globally impacted psychological health and well-being via increased stressors, such as uncertainty, health anxieties, and financial instability. During the initial months of the pandemic, we (Polizzi et al.

Predictors of milk cortisol in North American women.

Objectives: Human milk content varies across mother-child dyads, environments, and populations. Among the hormones in milk is cortisol, a glucocorticoid; its impact on the breastfeeding child is unknown. Milk cortisol may constitute a signal to the child's developing physiology which can shape characteristics (e.

First principles modeling of mechanical properties of binary alloys containing Ga, Sn, and In for soldering applications.

Using density functional theory, the elastic properties of various binary Ga, Sn, and In-based alloys have been calculated to determine their viability as potential replacements for toxic Pb-based solders. Computed quantities such as the bulk, shear, and Young'smoduli were used to evaluate the mechanical behavior of the studied materials. The Pugh ratioand Poisson's ratiowere utilized to quantify the ductility of the alloys.

Market integration, income inequality, and kinship system among the Mosuo of China.

Increased access to defensible material wealth is hypothesised to escalate inequality. Market integration, which creates novel opportunities in cash economies, provides a means of testing this hypothesis. Using demographic data collected from 505 households among the matrilineal and patrilineal Mosuo in 2017, we test whether market integration is associated with increased material wealth, whether increased material wealth is associated with wealth inequality, and whether being in a matrilineal vs.

Host exposure to a common pollutant can influence diversity-disease relationships.

Hosts and parasites are embedded in communities where species richness and composition can influence disease outcomes (diversity-disease relationships). The direction and magnitude of diversity-disease relationships are influenced by variation in competence (ability to support and transmit infections) of hosts in a community. However, host susceptibility to parasites, which mediates host competence, is not static and is influenced by environmental factors, including pollutants.

Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core.

The nucleus accumbens (NAc) core is involved in regulating stress and shaping reward seeking behaviours. Multiple neuromodulators, including dynorphin/kappa opioid receptor (KOR) and dopamine systems, converge in this area to influence behavioural outcomes. KOR activation acutely inhibits dopamine release and chronically depresses overall dopamine transmission.

Evaluating the interactive effects of artificial light at night and background color on tadpole crypsis, background adaptation efficacy, and growth.

Artificial light at night (ALAN) is a global pollutant of rising concern. While alterations to natural day-night cycles caused by ALAN can affect a variety of traits, the broader fitness and ecological implications of these ALAN-induced shifts remain unclear. This study evaluated the interactive effects of ALAN and background color on traits that have important implications for predator-prey interactions and fitness: crypsis, background adaptation efficacy, and growth.

Mindfulness and COVID-19-Related Stress: Staying Present During Uncertain Times.

Objectives: The SARS-CoV-2 (COVID-19) pandemic is recognized as a mass traumatic event in which COVID-19-related stress (CS) can indicate other trauma- and/or stressor-related disorder. The facets of mindfulness (observing, describing, acting with awareness, nonjudging, and nonreacting) have been linked to reductions in stress-related symptoms and thus may protect against CS. We extended previous research by evaluating mindfulness facets as resilience skills negatively related to CS.

Modified Born method for modeling melting temperature usingmolecular dynamics.

The prediction of a material's melting point through computational methods is a very difficult problem due to system size requirements, computational efficiency and accuracy within current models. In this work, we have used a newly developed metric to analyze the trends within the elastic tensor elements as a function of temperature to determine the melting point of Au, Na, Ni, SiOand Ti within ±20 K. This work uses our previously developed method of calculating the elastic constants at finite temperatures, as well as leveraging those calculations into a modified Born method for predicting melting point.

Chronic ethanol alters adrenergic receptor gene expression and produces cognitive deficits in male mice.

Hyperkateifia and stress-induced alcohol cravings drive relapse in individuals with alcohol use disorder (AUD). The brain stress signal norepinephrine (also known as noradrenaline) tightly controls cognitive and affective behavior and was thought to be broadly dysregulated with AUD. The locus coeruleus (LC) is a major source of forebrain norepinephrine, and it was recently discovered that the LC sends distinct projections to addiction-associated regions suggesting that alcohol-induced noradrenergic changes may be more brain region-specific than originally thought.

A critical review of effects on ethanol intake of the dynorphin/kappa opioid receptor system in the extended amygdala: From inhibition to stimulation.

The dynorphin (DYN)/kappa opioid receptor (KOR) system has increasingly been investigated as a possible pharmacotherapeutic target for alcohol use disorder, but findings on the direction of its effects have been mixed. Activation of KORs by DYN has been shown to elicit dysphoric effects, and the DYN/KOR system has canonically been considered particularly important in driving alcohol intake through negative reinforcement in dependent states. However, this review also highlights its activity in opposing the positive reinforcement that drives alcohol intake at earlier stages.

The Neandertal nature of the Atapuerca Sima de los Huesos mandibles.

The recovery of additional mandibular fossils from the Atapuerca Sima de los Huesos (SH) site provides new insights into the evolutionary significance of this sample. In particular, morphological descriptions of the new adult specimens are provided, along with standardized metric data and phylogenetically relevant morphological features for the expanded adult sample. The new and more complete specimens extend the known range of variation in the Atapuerca (SH) mandibles in some metric and morphological details.

Does the immune system of milk increase activity for infants experiencing infectious disease episodes in Kilimanjaro, Tanzania?

Introduction: Multiple studies have reported that milk immune content increases for infants experiencing infectious disease (ID) episodes, suggesting that the immune system of milk (ISOM) offers enhanced protection when needed to combat ID.

Methods: To test the hypothesis that ISOM content and/or activity increases during an infant's ID episode, we characterized milk secretory immunoglobulin A (sIgA; a major ISOM constituent) and in vitro interleukin-6 (IL-6) responses to Salmonella enterica and Escherichia coli, as system-level biomarkers of ISOM activity, in a prospective study among 96 mother-infant dyads in Kilimanjaro, Tanzania.

Results: After control for covariates, no milk immune variables (sIgA, Coef: 0.

Editorial: Evidence for Transactional Relations Between Reward Processing and Depressive Symptoms in Adolescence.

Reward processing deficits play a clear role in depression and depression risk. For example, more than a decade of research has shown that individual differences in initial reward responsiveness, indexed by the reward positivity (RewP) event-related potential (ERP) component, are associated with current depression and future depression risk. Mackin and colleagues' study builds on this previous literature by asking 2 key questions: (1) Is the magnitude of the impact of RewP on prospective changes in depressive symptoms similar during late childhood and adolescence? and (2) Are prospective links between RewP and depressive symptoms transactional, with depressive symptoms also predicting future change in RewP during this developmental window? These questions are important, because this is a time period during which rates of depression increase dramatically and when there are normative changes in reward processing.

On categorizing intimate partner violence: A systematic review of exploratory clustering and classification studies.

Many theorists have proposed that intimate partner violence (IPV) is not one homogeneous phenomenon but instead has several distinct types. For example, Johnson (1995) typology described some perpetrators' violence as stemming from a desire to control and others' violence stemming from emotional dysregulation, whereas Holtzworth-Munroe and Stuart's (1994) typology classified perpetrators by severity of violence, whether violence was specific to intimate partners and perpetrators' psychopathological profiles. Other typologies are based on personality profiles, severity levels, and variety of violent acts.

Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice.

Neuroimmune pathways regulate brain function to influence complex behavior and play a role in several neuropsychiatric diseases, including alcohol use disorder (AUD). In particular, the interleukin-1 (IL-1) system has emerged as a key regulator of the brain's response to ethanol (alcohol). Here we investigated the mechanisms underlying ethanol-induced neuroadaptation of IL-1β signaling at GABAergic synapses in the prelimbic region of the medial prefrontal cortex (mPFC), an area responsible for integrating contextual information to mediate conflicting motivational drives.

The ear of the Sima de los Huesos hominins (Atapuerca, Spain).

Previous studies on the morphology of the inner ear (semicircular canals and cochlea) in the Sima de los Huesos hominin sample have provided important results on the evolution of these structures in the Neandertal lineage. Similarly, studies of the anatomy of the external and middle ear cavities of the Sima de los Huesos hominins have also provided important data on the auditory capacities of this European Middle Pleistocene population. The present contribution provides unpublished data on three new middle ear variables from the Sima de los Huesos fossils and compares these data with values from samples of Pan troglodytes, Homo neanderthalensis and Homo sapiens.

A novel ego dissolution scale: A construct validation study.

Ego dissolution (i.e., ego loss, ego disintegration, ego death, or self-loss) is a conscious state marked by a loss or diminution of one's sense of self and a lack of first-person experience.