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Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity.
Angew Chem Int Ed Engl
March 2015
Department of Chemistry, State University of New York (SUNY), Binghamton University P. O. Box 6000, Binghamton, NY 13902 (USA).
The pH low insertion peptide (pHLIP) offers the potential to deliver drugs selectively to the cytoplasm of cancer cells based on tumor acidosis. The WT pHLIP inserts into membranes with a pH50 of 6.1, while most solid tumors have extracellular pH (pH(e)) of 6.
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