Dengue infection changes the expressions of CD154 and CD148 in human platelets.

Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response.

Dataset of leaves for quality assessment and machine learning applications.

is a significant medicinal herb extensively used in traditional oriental medicine and gaining global popularity. The primary constituents of leaves are triterpenoid saponins, which are predominantly believed to be responsible for its therapeutic properties. Ensuring the use of high-quality leaves in herbal medicine preparation is crucial across all medicinal practices.

Effect of Virtual Reality and Musical Earplug Temporal Tap Technique in Reduction of Gag Reflex in Pediatric Patients.

Background: Gagging is a stimulated, protective reflex to prevent any material from entering the mouth or oropharynx. However, a hyperactive gag reflex is a common occurrence and anxiety-provoking stimulus while performing routine clinical procedures. Impression making is a clinical procedure that causes pronounced gagging and severe discomfort to the patient.

Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India.

Aim: This study aims to examine the gene expression and DNA methylation patterns of angiogenic factors in the placentae of Indian women who underwent assisted reproductive technology (ART) procedures and their association with maternal one-carbon metabolites and birth outcome.

Methods: Placental gene expression and DNA methylation of angiogenic factors (, , , ) in Indian women who underwent ART procedures ( = 64) and women who conceived naturally (Non-ART) ( = 93) was investigated using RT-qPCR and Epitect Methyl-II PCR assay kits. Maternal plasma one-carbon metabolites were assessed by CMIA technology.

Esthetic Twin Block Approach for Correction of Developing Class II Division 1 Malocclusion of an 11-year-old Female Patient: A Case Report.

Unlabelled: An 11-year-old female patient with developing class II division 1 malocclusion having retrognathic mandible and crowding in the lower arch, horizontal growth pattern, with convex profile, hyperactive mentalis muscle, positive visual treatment objective (VTO) in cervical vertebral maturation indicator (CVMI) stage 4 was planned to be treated using modification of conventional twin block appliance. Though a wide variety of myofunctional appliances like activator, Bionator, and Frankel appliances can be delivered to the patient, twin block appliance being a mechanofunctional appliance is routinely preferred by operators due to simplicity of its design and construction in comparison to other appliances. One of the biggest challenges in management of growing patients with skeletal class II malocclusion is the compliance of patients in wearing the myofunctional appliances.

A method to enhance privacy preservation in cloud storage through a three-layer scheme for computational intelligence in fog computing.

Recent advancements in cloud computing have heightened concerns about data control and privacy due to vulnerabilities in traditional encryption methods, which may not withstand internal attacks from cloud servers. To overcome these issues about the data privacy and control of transfer on cloud, a novel three-tier storage model incorporating fog computing method has been proposed. This framework leverages the advantages of cloud storage while enhancing data privacy.

Effectiveness of Two Wavelengths of Diode Laser and Amorphous Calcium Phosphate-Casein Phosphopeptide Mousse in the Treatment of Dentinal Hypersensitivity: A Randomized Clinical Study.

In office methods for immediate relief of dentinal hypersensitivity (DH) has long been an area of research. This study compared the efficacy of 660 nm diode laser, 980 nm diode laser, and amorphous calcium phosphate-casein phosphopeptide (ACP-CPP) agent in the treatment of DH. A total of 39 patients with minimum three hypersensitive teeth in at least one quadrant were selected and randomly divided into three groups; Group A, B, and C patients were treated by 660 nm diode laser, 980 nm diode laser, and ACP-CPP agent, respectively.

Molecular simulations and machine learning methods for the identification of novel aurora A kinase inhibitors.

Aurora A kinase (AAK) is a serine/threonine kinase that stands out as a crucial regulator of mitosis, the complex process of cell division. Notably, the protein AAK plays vital roles in cell cycle regulation and encompasses centrosome maturation, spindle assembly, and chromosome segregation. All such functionalities are essential for ensuring accurate daughter cell formation.

Early onset fulminant neonatal sepsis and multiple serous effusions caused by in an extremely preterm neonate.

is a Gram-negative bacterium commonly isolated from environmental sources such as plants and soil. Infections in humans are usually reported following penetrating wounds or in hospital settings due to contaminated medical equipment. Neonatal sepsis caused by this organism is rare.

A Review of the Work of Dr. Jo E Frencken: The Pioneer of Atraumatic Restorative Treatment for Dental Caries.

Dr. Jo E Frencken is a stalwart in preventive dentistry and cariology. He has worked extensively in diagnosing, treating, and assessing outcomes related to dental caries.

Retraction: Evaluation of the Efficacy of the HaeNaem Zero Bone Loss Kit in Indirect Sinus Lift Using Osseodensification.

[This retracts the article DOI: 10.7759/cureus.73130.

Integrated machine learning and physics-based methods assisted de novo design of Fatty Acyl-CoA synthase inhibitors.

Background: Tuberculosis is an infectious disease that has become endemic worldwide. The causative bacteria (Mtb) is targeted via several exciting drug targets. One newly discovered target is the Fatty Acyl-CoA synthase, which plays a significant role in activating the long-chain fatty acids.

Correction: Evaluation of the Efficacy of the HaeNaem Zero Bone Loss Kit in Indirect Sinus Lift Using Osseodensification.

[This corrects the article DOI: 10.7759/cureus.73130.

Comparative Evaluation of Mogibacterium timidum in Diabetic Patients With Chronic Periodontitis, Nondiabetic Patients with Chronic Periodontitis, and Healthy Patients During Pretreatment and Posttreatment: A Real-Time PCR Study.

Introduction is a rod-shaped, anaerobic, gram-positive new bacteria. genus included new species such as , , and by taxonomic nomenclature in the year 2000. Its presence in oral bacterial flora is believed to increase severity of gingivitis and periodontitis, indicating some link between this bacterium and periodontal disease.

Evaluation of the Efficacy of the HaeNaem Zero Bone Loss Kit in Indirect Sinus Lift Using Osseodensification.

Aim The purpose of this study was to evaluate alveolar height at the antral floor following dental implant placement after an indirect sinus lift using osseodensification (OD) with the HaeNaem bur system. Materials and methods A total of 12 patients seeking implant rehabilitation in the maxillary posterior region were selected for the study. Preoperative cone beam CT (CBCT) was performed to measure the residual crestal bone height (RCBH).

Temporal cue based categorization and speech perception in noise among pediatric cochlear implant users.

Objectives: Voice onset time (VOT) has been identified as a potential temporal cue for predicting children's performance in speech-in-noise tasks, yet the relationship between these two factors has never been explored among children using CI. Hence, the present study aimed to explore the performance of children using CI on temporal cue-based syllable categorization test and speech perception in noise and examine the relationship between the two.

Methods: Temporal cue-based syllable categorization test was developed with the manipulation of /ba/ sound in 10 steps continuum with VOT varied between -74 ms to 26 ms.

Beyond the Curriculum: A Study of Awareness Regarding Research Work and Its Importance among Medical and Allied Undergraduate Students.

Participating in undergraduate research in research-focused countries enhances students' critical evaluation, innovation, and contribution skills. Medical research is essential for undergraduates as it develops their critical thinking and analytical skills for innovation and aids in their professional growth. Many Indian students might be unaware of research opportunities because of insufficient exposure and guidance within their academic programs and restricted access to research facilities and mentorship at their educational institutions.

Diagnosis and Management of Trauma Induced Unilateral Horizontal Canal BPPV with Apogeotropic Nystagmus in an Adolescent.

This study reported a distinctive case of an adolescent diagnosed with trauma induced BPPV posed by coexisting geotropic and apogeotropic nystagmus. The discussion highlights the pathophysiology and need for repeated vestibular rehabilitation sessions of repositioning manoeuvres for complete resolution of the vertigo.

Exploring the Therapeutic Potential of Noncoding RNAs in Alzheimer's Disease.

Despite significant research efforts, Alzheimer's disease (AD), the primary cause of dementia in older adults worldwide, remains a neurological challenge for which there are currently no effective therapies. There are substantial financial, medical, and personal costs associated with this condition.Important pathological features of AD include hyperphosphorylated microtubule-associated protein Tau, the formation of amyloid β (Aβ) peptides from amyloid precursor protein (APP), and continuous inflammation that ultimately results in neuronal death.

A dataset revolutionizing Indian bay leaf analysis.

Indian bay leaf is a crucial spice in Indian cuisine. However, its quality and authenticity are often compromised. To address this, we introduce The Digital Indian Bay leaf dataset, a comprehensive collection of high-resolution 5696 images capturing diverse bay leaf samples under controlled conditions.