Expert consensus and recommendations on the live attenuated hepatitis A vaccine and immunization practices in India.

While Hepatitis A Virus (HAV) vaccination in global immunization programs has shown a virtual elimination of the disease within few years of the vaccination program, changing epidemiological landscape in India underscores the need for evidence-based, updated guidance on immunization practices. In May 2024, a panel of 15 distinguished opinion leaders and an organizing committee convened for an intensive, face-to-face advisory board meeting on high burden of HAV infection among adults, increased mortality rate in adolescents, symptomatic presentation in children, and evolving landscape globally and within India. Extensive comparable deliberations on long-term follow-up data from India and data from country of origin advocated immunogenicity, tolerability, and long-term protective effects of single-dose live attenuated HAV vaccine in children.

Can switching stimulus polarity identify Meniere's disease? A preliminary investigation on ABR.

Background: Meniere's disease (MD) affects 0.2% to 0.5% of the global population, with regional variations.

A Cross-Sectional Study of Non-communicable Disease Risk Factors Among Non-diabetic and Non-hypertensive Population.

Introduction: Noncommunicable diseases, especially diabetes and hypertension, have emerged as significant public health challenges. Regular screening, even among healthy individuals, is essential for early diagnosis and prevention of complications.

Methods: This cross-sectional study was conducted in an urban ward of the Sangli-Miraj-Kupwad municipal corporation in Maharashtra, India, and cluster random sampling was used to collect data.

Species identification for Indian seafood markets: A machine learning approach with a fish dataset.

The Indian sea fish market is a dynamic and significant sector, contributing to both the domestic economy and the global seafood trade. This fish dataset is specifically curated for machine learning applications in the Indian seafood industry. It includes a comprehensive collection of images representing eight commercially significant fish species native to Indian waters, comprising a total of 8488 images.

Potential of flaxseed oil blends to modulate tissue fatty acid composition and determination of safety parameters in Wistar rats.

Non-communicable diseases (NCD) are associated with inflammation and oxidative stress which is further associated with omega-6 (ω6) and omega-3 (ω3) fatty acid (FA) imbalance favoring ω6 FA. By improving ω3 FA consumption, this imbalance can be altered to control NCD. Previously we have reported blends of flaxseed oil (FSO, ω3 FA) with palm olein (PO) or coconut oil (CO) were thermo-oxidatively stable with good storage stability and could improve ω6:ω3 ratio in cell lines.

Effect of Build Orientation on Mechanical and Physical Properties of Additively Manufactured Resins Using Digital Light Processing Technology in Dentistry: A Systematic Review.

Aim: The aim of this systematic review was to evaluate the effect of build orientation on the mechanical and physical properties of additively manufactured resin using digital light processing (DLP).

Background: The properties of 3D-printed materials are influenced by various factors, including the type of additive manufacturing (AM) system and build orientation. There is a scarcity of literature on the effect of build orientation on the mechanical and physical properties of additively manufactured resins using DLP technology in dentistry.

Evaluating Cost-effectiveness and Mixing Efficacy for Elastomeric and Temporary Restorative Material Using Two Mixing Tips: A SEM-EDS Analysis.

Aim: This study aimed to compare the mixing efficacy and cost-effectiveness of new T-mixer tips against the standard double helical tips for a light-body elastomeric impression and a temporary/interim restorative material using a scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy.

Methodology: Automixed samples ( = 16) were divided into four groups of four samples each: Samples that were mixed with Helical tip for elastomer, T-mixer tip for elastomer, Helical tip for interim restorative material, and T-mixer tip for interim restorative material. These samples were then evaluated for SEM analysis.

Acceptance of Parents toward Hand-over-mouth Exercise and Other Behavior Management Techniques for Pediatric Dental Care in the 21st Century: A Systematic Review and Meta-analysis of Observational Studies.

Background: Hand-over-mouth exercise (HOME) is an aversive technique for child behavior management in a dental office. HOME has been omitted from various guidelines and certain teaching curricula due to legal and ethical issues. This systematic review meta-analysis (SRMA) was undertaken to understand the acceptance of parents toward HOME in comparison with that of other behavior management techniques (BMTs).

Comparative Evaluation of Apical Leakage in Root Canal Obturation Using AH Plus Sealer, Bioceramic Sealer, and Bioceramic Sealer Incorporated With Chitosan Nanoparticles: An In Vitro Study.

Introduction Endodontic re-infections primarily occur due to the ingress of bacteria and their toxins through an incomplete seal following obturation. A variety of sealers have been developed to achieve effective integration with the different obturation materials and dentinal tubules. To choose the right endodontic sealer and application for each clinical instance, one must be aware of the attributes of the various sealers commonly used in clinical practice.

Neonatal upper limb arteriovenous malformation: a therapeutic challenge.

Arteriovenous malformations (AVMs) are rare congenital vascular malformations with associated morbidities. We describe a neonatal case of upper limb high-flow AVM presenting with upper limb soft tissue mass and postnatal high-output heart failure. Doppler study suggested high-flow AVM, and later magnetic resonance angiography of the right upper limb confirmed the diagnosis.

Cortical Laminar Bone Membrane: Transforming Regenerative Approaches in Dentistry.

Cortical laminar bone membrane (CLBM) is well known for its extraordinary mechanical properties, biocompatibility, and osteoconductive potential, and thus, it has been revealed as a revolutionary biomaterial in periodontal and alveolar bone regeneration. CLBM offers a superior alternative to traditional barrier membranes used in guided bone regeneration (GBR) and guided tissue regeneration (GTR). CLBM represents a significant advancement in managing complex defects by overcoming common limitations such as premature degradation and inadequate soft tissue support.

Role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting carcinoma prostate (CaP) in patients with lower urinary tract symptoms and raised serum prostate-specific antigen (sr.PSA).

Background: Carcinoma prostate (CaP) is second most common cancer and sixth leading cause of cancer-related mortality among men worldwide. Prostate-specific antigen (sr. PSA) levels are prostate specific, not cancer specific.

Renal artery angioplasty in Takayasu disease: Difficult anatomy addressed with a novel technique.

Takayasu arteritis is a well-established medical entity involving inflammatory changes in large arteries. We describe a characteristic case of Takayasu arteritis, in a young woman with significant renal artery stenosis, presenting with hypertensive urgency. Unsuccessful guide wire passage due to fibrotic septae in lumen of the left renal artery necessitated an innovative interventional approach, using an IMA-guide catheter and a UB3 coronary guidewire to cross the lesions, followed by placement of a coronary drug eluting stent, with an aim to avoid restenosis.

Angiogenic Markers in Gestational Diabetes and their Association with Placental Dimensions.

GDM is an increasing global concern, with its etiology not fully understood, though altered placental function is likely to play a role. Placental angiogenesis, essential for sufficient blood flow and nutrient exchange between mother and fetus, may be affected by GDM. However, the role of angiogenic markers in GDM remains unclear.

Knowledge, attitude, and experience of dentists toward child abuse and neglect. A cross-sectional study.

Context: Child abuse and neglect can be described as all kinds of physical, emotional, and sexual abuse, neglect, commercial and/or any other type of exploitation resulting in any potential of causing hurt or an actual form of harm to a child's general health, growth, survival, and dignity. The dentist is in a position to identify physical signs of physical abuse in a child hence, it is important to gauge the knowledge level and perception regarding child abuse and neglect.

Aim: The aim of the present study was to ascertain the knowledge, attitude, and experience regarding child abuse and neglect among dentists in India.

Knowledge and awareness of child sexual abuse related to POCSO (Protection of Children from Sexual Offences) Act among medical and dental professionals in India: A cross-sectional study.

Background: The POCSO (Protection Of Children from Sexual Offences) Act was introduced in 2012 as a measure to safeguard and prevent interests of children affected by sexual crimes. Both medical and dental professionals are capable of identifying such cases.

Aim: The aim of this study was to evaluate the knowledge and awareness of child sexual abuse related to POCSO Act among both medical and dental professionals in India.

Matairesinol repolarizes M2 macrophages to M1 phenotype to induce apoptosis in triple-negative breast cancer cells.

Objective: Triple-Negative Breast Cancer (TNBC), the most challenging subtype of Breast Cancer (BC), currently lacks targeted therapy, presenting a significant therapeutic gap in its management. Tumor Associated Macrophages (TAMs) play a significant role in TNBC progression and could be targeted by repolarizing them from M2 to M1 phenotype. Matairesinol (MAT), a plant lignan, has been shown to exhibit anticancer, anti-inflammatory and immunomodulatory activities.

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies.

Alzheimer's disease (AD), the most common kind of dementia worldwide, is characterized by elevated levels of the amyloid-β (Aβ) peptide and hyperphosphorylated tau protein in the neurons. The complexity of AD makes the development of treatments infamously challenging. Apolipoprotein E (APOE) genes's ɛ4 allele is one of the main genetic risk factors for AD.

Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment.

Alzheimer's disease (AD) treatments currently available have ineffective results. Previously employed Acetylcholine esterase inhibitors and memantine, an NMDA receptor antagonist, target a single target structure that plays a complex role in the multifactorial progression of disease. Memantine moderates the toxic effects of excessive glutamate activity by blocking NMDA receptors, which decreases neurotoxicity in AD, while acetylcholine esterase inhibitors function by blocking cholinergic receptors (muscarinic and nicotinic), preventing the breakdown of acetylcholine, thereby enhancing cholinergic transmission, thus improving cognitive functions in mild to moderate stages of AD.

Dengue infection changes the expressions of CD154 and CD148 in human platelets.

Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response.

Dataset of leaves for quality assessment and machine learning applications.

is a significant medicinal herb extensively used in traditional oriental medicine and gaining global popularity. The primary constituents of leaves are triterpenoid saponins, which are predominantly believed to be responsible for its therapeutic properties. Ensuring the use of high-quality leaves in herbal medicine preparation is crucial across all medicinal practices.