Genomic insights into fish pathogenic bacteria: A systems biology perspective for sustainable aquaculture.

Fish diseases significantly challenge global aquaculture, causing substantial financial losses and impacting sustainability, trade, and socioeconomic conditions. Understanding microbial pathogenesis and virulence at the molecular level is crucial for disease prevention in commercial fish. This review provides genomic insights into fish pathogenic bacteria from a systems biology perspective, aiming to promote sustainable aquaculture.

Synthesis of new 1,4-dihydropyridine derivative, anti-cancer, bacterial activity, molecular docking and adsorption, distribution, metabolism and excretion analysis.

The amination and cyclization method developed a new strategy for designing and assembling new 1,4-dihydropyridine derivatives of compounds 3a-g and 4a-g. Newly prepared pyridine compounds are more economical, and reduce the reaction time. FT-IR, H-NMR, 13C-NMR, mass spectroscopy and elemental analyses elucidated the synthesized derivatives.

Synthesis of β-enamino malonates through caesium carbonate-promoted reaction of nitro-substituted donor-acceptor cyclopropanes.

A caesium carbonate-promoted reaction of nitro-substituted donor-acceptor cyclopropanes (DACs) with primary aromatic amines in water provides a convenient access to β-enamino malonates under mild reaction conditions. The transformation takes place through the formation of allene intermediates from the DACs followed by the conjugate addition of various primary aromatic amines to the intermediates. The reaction proceeds more efficiently in water as compared with organic solvents and the products were isolated in good yields by filtering through a silica gel column without any prior extraction procedure.

Exploring the versatility of Porphyridium sp.: A comprehensive review of cultivation, bio-product extraction, purification, and characterization techniques.

Interest in red microalgae of the Porphyridium genus has surged due to their richness in phycobiliproteins, polyunsaturated fatty acids, and sulfated polysaccharides. These biomasses and their derivatives find applications across food, feed, nutraceutical, pharmaceutical, and cosmetic industries. A deeper understanding of their properties and extraction methods is essential to optimize downstream processing.

Endophytic Streptomyces: an underexplored source with potential for novel natural drug discovery and development.

Streptomyces has long been considered as key sources for natural compounds discovery in medicine and agriculture. These compounds have been demonstrated to possess different biological activities, including antibiotic, antifungal, anticancer, and antiviral effects. As a result, new pharmaceuticals and antibiotics have been developed.

Significance of Viable But Non-culturable (VBNC) State in Vibrios and Other Pathogenic Bacteria: Induction, Detection and the Role of Resuscitation Promoting Factors (Rpf).

Still, it remains a debate after four decades of research on surviving cells, several bacterial species were naturally inducted and found to exist in a viable but non-culturable (VBNC) state, an adaptive strategy executed by most bacterial species under different stressful conditions. VBNC state are generally attributed when the cells lose its culturability on standard culture media, diminish in conventional detection methods, but retaining its viability, virulence and antibiotic resistance over a period of years and may poses a risk to marine animals as well as public health and food safety. In this present review, we mainly focus the VBNC state of Vibrios and other human bacterial pathogens.

Sustainable Fabrication of Luminescent Zinc Oxide Nanoparticles From Cucumis melo Fruit Peel Extract as Prospective Photocatalytic and Antigermicidal Agent.

The focus of current advances in nanotechnology has shifted significantly towards environmentally conscious methods that use harmless ingredients and moderated reaction circumstances to promote equitable development. Zinc oxide nanoparticles (NPs) currently grabbed attention of multiple medical fields owing to their unique ability to safeguard against cellular damage and alleviate serious human diseases via processes related to metabolism. This work focused on the generation of ZnO NPs using the peel of Cucumis melo fruit.

Stimulus-induced dynamical states in an adaptive network with symmetric adaptation.

We consider an adaptive network of identical phase oscillators with the symmetric adaptation rule for the evolution of the connection weights under the influence of an external force. We show that the adaptive network exhibits a plethora of self-organizing dynamical states such as the two-cluster state, multiantipodal clusters, splay cluster, splay chimera, forced entrained state, chimera state, bump state, coherent, and incoherent states in the two-parameter phase diagrams. The intriguing structures of the frequency clusters and instantaneous phases of the oscillators characterize the distinct self-organized synchronized and partial synchronized states.

Reservoir computing with logistic map.

Recent studies on reservoir computing essentially involve a high-dimensional dynamical system as the reservoir, which transforms and stores the input as a higher-dimensional state for temporal and nontemporal data processing. We demonstrate here a method to predict temporal and nontemporal tasks by constructing virtual nodes as constituting a reservoir in reservoir computing using a nonlinear map, namely, the logistic map, and a simple finite trigonometric series. We predict three nonlinear systems, namely, Lorenz, Rössler, and Hindmarsh-Rose, for temporal tasks and a seventh-order polynomial for nontemporal tasks with great accuracy.

Effect control of novel Hirudinaria manillensis extract on the molecular regulation of EGFR gene and its protein expression in HeLa cells.

Background: Most anticancer drugs possess the capacity to control precise molecular processes and gene-regulated protein expressions, which could enhance the efficacy of cancer treatments. Hirudinaria manillensis is prevalent in South Asia and has been employed for several decades in medical conditions based on its curative benefits.

Methods And Results: The present study aimed to explore the molecular regulation of the target EGFR gene, and the protein expression of EGFR on the HeLa cell line.

Whole-genome sequence of NRMCF6962, isolated from lake water.

The economically important Cyanobacterial genus is commercially utilized as a dietary supplement and nutraceutical agent. We present the whole-genome sequence of NRMCF6962 and was isolated from Kondakarla Ava Lake of Visakhapatnam, Andhra Pradesh, India.

Dataset on bacterial diversity using 16S metagenome analysis in fermented rice beer from two breweries and grape wine of Mizoram, Northeast India.

The microbial diversity of fermented rice beer and grape wine in Mizoram was explored using 16S metagenome analysis. The collected samples were marked as C1 and B1 for fermented rice beer and D1 for grape wine. Next-generation sequencing of the 16S rRNA (V3-V4 region) was performed using the Illumina NovoSeq 6000 platform.

Mixed-ligand copper(ii)-diimine complexes of 3-formylchromone- -phenyl thiosemicarbazone: 5,6-dmp co-ligand confers enhanced cytotoxicity.

The promising biological applications of thiosemicarbazone derivatives have inspired the design, synthesis, and study of their Cu(ii) complexes for anticancer therapeutic applications. Herein, we have evaluated the DNA/protein binding, DNA cleaving, and cytotoxic properties of four mixed-ligand Cu(ii) complexes of the type [Cu(L)(diimine)](NO) 1-4, where HL is 4-oxo-4-chromene-3-carbaldehyde-4()-phenylthiosemicarbazone and diimine is 2,2'-bipyridine (bpy, 1) 1,10-phenanthroline (phen, 2), 5,6-dimethyl-1,10-phenanthroline (5,6-dmp, 3), or dipyrido-[3,2-:2',3'-]-quinoxaline (dpq, 4). Interestingly, complex 3 with higher lipophilicity shows stronger DNA binding and oxidative DNA cleavage, higher ROS production, and more reversible redox behaviour, resulting in its remarkable cytotoxicity (IC, 1.

Functional significance of earthworm clitellum in regulating the various biological aspects of cell survival and regeneration.

Earthworms are a highly abundant species in nature, with nearly 7000 different species being discovered. Despite the similarities in morphology among earthworm species, their regeneration capabilities vary based on the clitellum. The clitellum plays a crucial role in the clitellum-dependent worms, as it is involved in the processes of regeneration and reproduction in earthworms.

Synthesis and Fabrication of Metal Cation Intercalation in Multilayered TiCT Composite CNF Electrode for Asymmetric Coin Cell Supercapacitors.

TiCT has attracted considerable attention from researchers in energy storage due to its unique structure and beneficial surface functional group characteristics. Recent studies have focused extensively on developing TiCT composites to create potential electrode materials for energy storage applications. Carbon nanofiber is often combined with TiCT to produce high-performance functional nanocomposites, effectively harnessing the unique properties of TiCT nanosheets while ensuring exceptional electrochemical behavior.

Mechanical Force on Hydrogel Implication on Enhanced Drug Release, Antibacterial, and M2 Macrophage Polarization: New Insights Alleviate Diabetic Wound Healing.

Diabetic foot ulcers/chronic wounds are difficult to treat because of dysfunctional macrophage response and decreased phenotype transition from the M1 to M2 status. This causes severe inflammation, less angiogenesis, microbial infections, and small deformation in wound beds, affecting the healing process. The commercial wound dressing material has limited efficacy, poor mechanical strength, extra pain, and new granulated tissue formed in a mesh of gauze.

Metagenomic analysis of pathogenic bacteria and virulence factor genes in coastal sediments from highly urbanized cities of India.

A metagenomic approach was employed to investigate the diversity and distribution of Virulence Factors Genes (VFGs) and Pathogenic Bacteria (PB) in sediment samples collected from highly urbanized cities along the Indian coastline. Among the study locations, Mumbai, Veraval and Paradeep showed a higher abundance of PB, with Vibrio and Pseudomonas as dominant at the genus level, and Escherichia coli and Pseudomonas aeruginosa at the species level. In total, 295 VFGs were detected across all sediment samples, of which 40 VFGs showed a similarity of ≥90 % with the Virulence Database (VFDB) and were focused in this study.

Elucidating the interplay of PPAR gamma inhibition and energy demand in adriamycin-induced cardiomyopathy: In Vitro and In Vivo perspective.

Adriamycin is an anticancer anthracycline drug that inhibits the progression of topoisomerase II activity and causes apoptosis. The effective clinical application of the drug is very much limited by its adverse drug reactions on various tissues. Most importantly, Adriamycin causes cardiomyopathy, one of the life-threatening complications of the drug.

Insights into nonlinear absorption transitions in a silver-incorporated reduced graphene oxide-molybdenum disulfide (Ag-rGO-MoS) hybrid.

Optical nonlinearity in a silver-decorated reduced graphene oxide-molybdenum disulfide (Ag-rGO-MoS) nanocomposite was experimentally investigated the -scan technique using a Q-switched Nd:YAG nanopulsed green laser. An interesting switching behaviour from saturable to reverse saturable absorption with varying input on-axis intensity of the laser was demonstrated. Under low-intensity laser excitation, Ag-rGO-MoS displayed ground-state bleaching, which resulted in saturable absorption (SA) behaviour.

Synthesis of omega-3 mediated copper (ω-3-Cu) and copper oxide (ω-3-CuO) nanocatalyst dual application of dye decolourization and aerobic oxidation of eco-friendly sustainable approach.

In this study, ω-3-Cu and ω-3-CuO nanocatalysts were investigated for industrial environmental issues. Nowadays, green methodology is very important for addressing industrial environmental issues. In this regard, the current study focuses on ω-3-Cu and ω-3-CuO used for aerobic oxidation and dye decolourization via an eco-friendly approach.

Ytterbium Triflate-Catalyzed Intramolecular Arylative Ring Opening of Arylaminomethyl-Substituted Donor-Acceptor Cyclopropanes: Access to Tetrahydroquinolines.

The treatment of arylaminomethyl-substituted donor-acceptor cyclopropanes with a catalytic amount of Yb(OTf) provides expedient access to tetrahydroquinoline derivatives. The transformation proceeds through an intramolecular S2-type attack of the aminomethyl-containing aryl ring on the cyclopropane ring, leading to the formation of the products as single diastereomers.

Cu(II)-tyrosinase enzyme catalyst mediated synthesis of mosquito larvicidal active pyrazolidine-3,5-dione derivatives with molecular docking studies and their ichthyotoxicity analysis.

The objective of this study was to develop pyrazolidine-3,5-dione derivatives with potential as environmentally friendly pesticides for pest control, specifically focusing on their efficacy as larvicidal agents. A novel one-pot synthesis of multicomponent pyrazolidine-3,5-dione derivatives (1a-m) was accomplished via the grindstone method using Cu(II)tyrosinase enzyme as a catalyst under mild reaction conditions, yielding 84%-96%. The synthesised derivatives (1a-m) were characterized using various spectroscopic methods (mass spectrometry, elemental analysis, FT-IR, and 1H and 13C NMR).