Cellular and chromosomal interaction of bio-synthesized copper oxide nanoparticles - Induced nano-cytotoxicity and genotoxicity.

The widespread use of nanoparticles raises substantial environmental, health, and safety issues. The specific mechanisms by which they impact plants and animals, as well as the entire scope of their possible impact, are still unknown. The current work investigates the impact of varying CuO NPs concentrations on phytotoxicity, cytotoxicity, genotoxicity, and antioxidant activity.

2D Co-anti-MXenes (CoB/CoP) as promising anode materials for magnesium-ion batteries in diglyme and triglyme electrolytes: a first-principles study.

Magnesium-ion batteries have the potential to replace commercially available Li-ion batteries in the future due to their lower cost and sustainability. On the other hand, magnesium ions are dendrite-free and offer greater energy density and volumetric capacity due to their divalent nature. Conventional electrode materials face challenges in capturing magnesium ions.

Nano-bio-encapsulation of phyto-vaccines: a breakthrough in targeted cancer immunotherapy.

Nano bio-encapsulation of phyto-vaccines for cancer has marked a cutting-edge strategy that brings together nanotechnology with plant-derived vaccines to enhance cancer therapy. Phyto-vaccines, isolated from bioactive compounds found in plants called protein bodies, have been shown to potentially stimulate the immune system to recognise and destroy cancer cells. However, challenges such as poor stability, rapid degradation, and limited bioavailability in the body have hindered their clinical application.

Microbial Bacterioruberin: A Comprehensive Review.

Bacterioruberin (BR) is a fat-soluble, dipolar, reddish pigment predominantly found in halophilic archaea. BR is a rare C50 carotenoid from the xanthophyll family, and it has been extensively studied for its potent antioxidant properties, such as its ability to protect cells from oxidative stress. In addition, several studies have shown that BR-rich extracts and its derivatives exhibit significant antiviral, antidiabetic, antibacterial, and anti-inflammatory effects, making them ideal candidates for the development of novel therapeutic interventions against various diseases.

Integrin α1 upregulation by TF:FVIIa complex promotes cervical cancer migration through PAR2-dependent MEK1/2 activation.

Tissue factor (TF) and protease-activated receptor 2 (PAR2) have been associated with the progression of cancer, while integrins are essential for the adhesion and migration of cancer cells. This study aimed to explore the cross-talk between the TF:FVIIa complex, PAR2 signaling, and the expression of integrin α1 in cervical cancer cells. Utilizing data from The Cancer Genome Atlas (TCGA), the research examined the relationship between the TF and PAR2 genes and the integrin α1 gene (ITGA1) in reproductive cancers, revealing a positive correlation between integrin α1 expression and both TF and PAR2 genes.

Chemotherapeutic potential of radotinib against blood and solid tumors: A beacon of hope in drug repurposing.

Tyrosine kinase inhibitors (TKIs) represent a pivotal class of targeted therapies in oncology, with multiple generations developed to address diverse molecular targets. Imatinib is the first TKI developed to target the BCR-ABL1 chimeric protein, which is the key driver oncogene implicated in Philadelphia chromosome-positive chronic myeloid leukemia (CML). Several second-generation tyrosine kinase inhibitors (2GTKIs), such as nilotinib, dasatinib, bosutinib, and radotinib (RTB), followed the groundbreaking introduction of imatinib.

Analysing the apoptotic potential of green synthesized Nyctanthes arbor-tristis chitosan nanoparticles in MDA-MB-231 and SKOV3 cell lines.

Gynecological tumors are highly aggressive cancers in women, often treated with conventional treatments that can cause significant side effects. This study focuses on the preparation of chitosan nanoparticles from Nyctanthes arbor-tristis leaves, which possess anti-tumor properties, to address and overcome these issues. The successfully synthesized nanoparticles were characterized by UV-spectroscopy, DLS, TEM, and FTIR spectroscopy to analyze their physiochemical properties.

Leveraging deep transfer learning and explainable AI for accurate COVID-19 diagnosis: Insights from a multi-national chest CT scan study.

The COVID-19 pandemic has emerged as a global health crisis, impacting millions worldwide. Although chest computed tomography (CT) scan images are pivotal in diagnosing COVID-19, their manual interpretation by radiologists is time-consuming and potentially subjective. Automated computer-aided diagnostic (CAD) frameworks offer efficient and objective solutions.

Unraveling the Autoxidation Mechanisms of Limonene, α-Pinene, and β-Pinene: A Computational Study with Reactivity Prediction Models.

The hydrogen shift reactions of peroxy radicals derived from the ȮH-initiated oxidation of three atmospherically important monoterpenes, limonene, α-pinene, and β-pinene, have been studied. The Bell-Evans-Polanyi relationship (BEPR), Marcus cross relationship (MCR), and Robert-Steel relationship (RSR) are employed to study the factors that contribute to the kinetics of the H-shift reactions. Our results show distinct kinetic behaviors based on the size of the transition-state ring, the functional group present at the H atom abstraction site, and the type of carbon-centered radical formed.

Esculin, a Coumarin Glucoside Prevents Fluoride-Induced Oxidative Stress and Cardiotoxicity in Zebrafish Larvae.

Fluoride (F) is a major groundwater contaminant spread across the world. In excess concentrations, F can be detrimental to living beings. F exposure is linked to cellular redox dyshomeostasis, leading to oxidative stress-mediated pathologies including heart dysfunction.

Structure based interaction and molecular dynamics studies of cysteine protease Cathepsin B against curcumin and resveratrol.

The lysosomal cysteine peptidase Cathepsin B is identified as a pivotal contributor to cancer development. In the pursuit of discovering less toxic inhibitors for Cathepsin B, various organic compounds have undergone thorough investigation and are being studied at the moment in clinical studies for cancer treatment. Notably, curcumin and resveratrol emerge as prominent candidates.

Copper oxide nanoparticles induced reactive oxygen species generation: A systematic review and meta-analysis.

Copper oxide nanoparticles (CuO NPs) are widely employed in various industrial and biomedical applications owing to their enhanced physicochemical characteristics. However, concerns regarding their adverse effects on biological systems upon entering the environment remain unexplored. The generation of reactive oxygen species (ROS) is one of the primary mechanisms in CuO NPs induced toxicity.

Investigating the Antiproliferative Activity of Novel 4-Chloro-8-Nitro-1,2-Dihydro-3-Quinoline Acylhydrazones on Human Cervical Cancer Cell Lines.

A new series of acyl hydrazones have been synthesized from 4-chloro-8-nitro-1,2-dihydroquinoline-3-carbaldehyde. These compounds were characterized using various spectroscopic techniques. Density functional theoretical (DFT) studies were conducted to understand the correlation between electronic parameters and biological activity.

Screening of multi-metal tolerant plant growth promoting bacteria (PGPB) WA4 and its assistance on phytoextraction of heavy metals (Cu, Ag and Pb).

In the current study, coal fly ash contaminated soil was collected in and around Mettur Thermal Power Station, Salem district, Tamil Nadu. The metal concentrations present in the coal fly ash soil samples were analyzed and also used for the isolation of bacteria. The isolates were screened for their multi-metal resistance against three heavy metals (Cu, Ag and Pb) and plant growth-promoting traits (siderophore, phosphate solubilization, IAA, cellulase, HCN, and ammonia production).

Demystifying Synergistic Multifunctional Electrocatalysis of N-Doped Graphene/WS Heterostructure with Single-Atom Catalysts for Water Splitting and Fuel Cells.

As the demand for sustainable energy continues to rise, electrocatalysis has become increasingly prominent in the advancement of clean energy technologies. By scrutinizing the material to function as a multifunctional catalyst, the effectiveness of energy conversion processes is significantly enhanced. This study focuses on harnessing graphene/WS van der Waals heterostructures for overall water splitting and fuel cell applications, using transition metals (TMs) from Sc-Zn as single-atom catalysts (SACs).

Delineating Notch1 and Notch2: Receptor-Specific Significance and Therapeutic Importance of Pinpoint Targeting Strategies for Hematological Malignancies.

Notch1 and Notch2, transmembrane receptors belonging to the Notch family, are pivotal mediators of intercellular communication and have profound implications including cell fate determination, embryonic development, and tissue homeostasis in various cellular processes. Despite their structural homology, Notch1 and Notch2 exhibit discrete phenotypic characteristics and functional nuances that necessitate their individualized targeting in specific medical scenarios. Aberrant Notch signaling, often driven by the dysregulated activity of one receptor over the other, is implicated under various pathological conditions.