Novel therapeutic approaches targeting cancer stem cells: Unveiling new frontiers in breast cancer treatment.

Breast cancer remains the leading cause of mortality among women with cancer. This article delves into the intricate relationship between breast cancer and cancer stem cells (CSCs), emphasizing advanced methods for their identification and isolation. The key isolation techniques, such as the mammosphere formation assay, surface marker identification, Side Population assay, and Aldehyde Dehydrogenase assay, are critically examined.

Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective.

Microneedles (MNs) appear as a transformative and minimally invasive platform for transdermal drug delivery, representing a highly promising strategy in wound healing therapeutics. This technology, entailing the fabrication of micron-scale needle arrays, enables the targeted and efficient delivery of bioactive agents into the epidermal and dermal layers without inducing significant pain or discomfort. The precise penetration of MNs facilitates localized and sustained drug release, which significantly enhances tissue regeneration and accelerates wound closure.

In silico analysis and gene expression patterns of lignin peroxidase isozymes in Phanerochaete chrysosporium.

Phanerochaete chrysosporium (Pc), is a prominent lignin-degrading fungus which serves as an important source for lignin-degrading enzymes (LDEs). The present study was focused on a detailed in silico analysis and gene expression patterns of lignin peroxidases (PcLiPs), which is a significant class of LDEs. In spite of extensive research on P.

Valorization of pineapple (ANANAS comosus) peel waste for levan production: Assessment of biological activities.

Levan canopies a pivotal role in all the emerging sectors owing to its non-toxic and biodegradable nature. However, their expensive production impeded their commercialization and made them uneconomical. Hence the current work is focused on harnessing the pineapple peel as a viable substrate for bacterial fermentation to promote levan production.

Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review.

Nuclear factor kappa B (NF-kB) is a kind of transcription factor which resides in cytoplasm of each cell and on activation, it translocates to the nucleus. It is activated by a many inducible agents including endotoxins, inflammatory stimuli, carcinogens, pathogens, nicotine, and tumour promoters, etc. NF-kB is activated by canonical and non-canonical signalling pathways which has different signalling compounds and its biological functions.

New insights on the regulators and inhibitors of RhoA-ROCK signalling in Parkinson's disease.

A multifaceted and widely prevalent neurodegenerative disease, Parkinson's disease (PD) is typified by the loss of dopaminergic neurons in the midbrain. The discovery of novel treatment(s) that can reverse or halt the course of the disease progression along with identifying the most reliable biomarker(s) in PD remains the crucial concern. RhoA in its active state has been demonstrated to interact with three distinct domains located in the central coiled-coil region of ROCK.

Chitosan Nanoparticle-Mediated Delivery of R.Br. Root Methanolic Extract: A Promising Strategy for Breast Cancer Therapy in DMBA-Induced Breast Cancer in Sprague Dawley Rats.

R.Br., a plant native to the Western Ghats, is recognized for its diverse medicinal properties.

Toxicological Impact of Chronic Chlorpyrifos Exposure: DNA Damage and Epigenetic Alterations Induces Neoplastic Transformation of Liver Cells.

Organophosphate pesticides (OPPs) are widely used chemical pesticides in all the developed countries. Among the OPPs, Chlorpyrifos (CPF) is predominantly used and has been linked to various adverse health effects from acute to chronic exposure. Exposure to pesticides both occupationally and environmentally causes frequent human health problems including neurological disorders, liver, kidney dysfunctions and cancer.

Retraction notice to "Copper oxide nanoparticles synthesized from an endophytic fungus Aspergillus terreus: Bioactivity and anti-cancer evaluations" [Environ. Res. 201 (2021) 111502].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/locate/withdrawalpolicy).

Defect-assisted surface modification of a g-CN@WC heterostructure for tetracycline degradation: DFT calculations, degradation pathways, and nematode-based ecological assessment.

Eliminating hazardous antibiotics from aquatic environments has become a major concern in recent years. Tetracycline (TC) compounds pose a challenge for the selective degradation of harmful chemical groups. In this study, we successfully designed carbon vacancies in a gCN@WC (GW) heterostructure for the effective removal of TC pollutants under visible light.

Novel biosynthesized zinc selenite photocatalysts for enhanced degradation of oxytetracycline and Rhodamine B dye with antibacterial activity.

A novel biosynthesis approach was used to develop zinc selenite (ZnSeO) catalysts from the plant extracts of Nephrolepis cordifolia (ZnSeO:NC) and Ziziphus jujube (ZnSeO:ZJ) using hydrothermal method. This study investigates the structural, morphological, and optical properties of pure and biosynthesized ZnSeO catalysts. X-ray diffraction (XRD) analysis confirms the presence of an orthorhombic phase in both catalyst types.

Morphological, Anatomical, and Histochemical Study of Cordia diffusa K.C. Jacob-A Steno Endemic Plant.

Cordia diffusa K.C. Jacob, known as Sirunaruvili, belonging to the family Boraginaceae, is a rare endemic species.

Factors associated with decision-making on fertility among rural women in the central district of Tamil Nadu.

Introduction: Fertility decision-making is an important factor affecting the Total Fertility Rate. Good communication between partners encourages shared decision-making and equal participation. Women's decision-making plays an important role in determining their reproductive health and fertility behaviour.

Marine microalgae - Mediated biodegradation of polystyrene microplastics: Insights from enzymatic and molecular docking studies.

Biodegradation of microplastics (MPs) through microalgal strains would be of eco-friendly approach for significant pollution abatement. Polystyrene (PS) is a major contaminant in the marine environment; however studies on marine microalgal degradation of PS MPs have been very limited. In the present study, six marine microalgal strains viz.

Overexpression of an NF-YB gene family member, EaNF-YB2, enhances drought tolerance in sugarcane (Saccharum Spp. Hybrid).

Background: Drought is one of main critical factors that limits sugarcane productivity and juice quality in tropical regions. The unprecedented changes in climate such as monsoon failure, increase in temperature and other factors warrant the need for development of stress tolerant cultivars to sustain sugar production. Plant Nuclear factor (NF-Y) is one of the major classes of transcription factors that have a major role in plant development and abiotic stress response.

Anatomical and Physicochemical Attributes of Endemic Medicinal Plant Species Vincetoxicum capparidifolium (Wight & Arn.) Kuntze, Apocynaceae.

Vincetoxicum capparidifolium (Wight & Arn.) Kuntze [=Tylophora capparidifolia (Wight & Arn.) Kuntze], belonging to the family Apocynaceae, is a medicinal plant species endemic to the southern Western Ghats, Tamil Nadu, India.

Phytochemical composition, in vitro cytotoxicity and in silico ADME/Tox analysis of the active compounds of Kunth. extracts with promising anticancer potential.

Unlabelled: This study investigated the anticancer phytocompounds in leaf extracts of Kunth. Quantitative analysis of the phytochemical composition showed high levels of primary metabolites: carbohydrates (45.11 ± 2.

Cellular and chromosomal interaction of bio-synthesized copper oxide nanoparticles - Induced nano-cytotoxicity and genotoxicity.

The widespread use of nanoparticles raises substantial environmental, health, and safety issues. The specific mechanisms by which they impact plants and animals, as well as the entire scope of their possible impact, are still unknown. The current work investigates the impact of varying CuO NPs concentrations on phytotoxicity, cytotoxicity, genotoxicity, and antioxidant activity.

2D Co-anti-MXenes (CoB/CoP) as promising anode materials for magnesium-ion batteries in diglyme and triglyme electrolytes: a first-principles study.

Magnesium-ion batteries have the potential to replace commercially available Li-ion batteries in the future due to their lower cost and sustainability. On the other hand, magnesium ions are dendrite-free and offer greater energy density and volumetric capacity due to their divalent nature. Conventional electrode materials face challenges in capturing magnesium ions.

Nano-bio-encapsulation of phyto-vaccines: a breakthrough in targeted cancer immunotherapy.

Nano bio-encapsulation of phyto-vaccines for cancer has marked a cutting-edge strategy that brings together nanotechnology with plant-derived vaccines to enhance cancer therapy. Phyto-vaccines, isolated from bioactive compounds found in plants called protein bodies, have been shown to potentially stimulate the immune system to recognise and destroy cancer cells. However, challenges such as poor stability, rapid degradation, and limited bioavailability in the body have hindered their clinical application.

Microbial Bacterioruberin: A Comprehensive Review.

Bacterioruberin (BR) is a fat-soluble, dipolar, reddish pigment predominantly found in halophilic archaea. BR is a rare C50 carotenoid from the xanthophyll family, and it has been extensively studied for its potent antioxidant properties, such as its ability to protect cells from oxidative stress. In addition, several studies have shown that BR-rich extracts and its derivatives exhibit significant antiviral, antidiabetic, antibacterial, and anti-inflammatory effects, making them ideal candidates for the development of novel therapeutic interventions against various diseases.

Integrin α1 upregulation by TF:FVIIa complex promotes cervical cancer migration through PAR2-dependent MEK1/2 activation.

Tissue factor (TF) and protease-activated receptor 2 (PAR2) have been associated with the progression of cancer, while integrins are essential for the adhesion and migration of cancer cells. This study aimed to explore the cross-talk between the TF:FVIIa complex, PAR2 signaling, and the expression of integrin α1 in cervical cancer cells. Utilizing data from The Cancer Genome Atlas (TCGA), the research examined the relationship between the TF and PAR2 genes and the integrin α1 gene (ITGA1) in reproductive cancers, revealing a positive correlation between integrin α1 expression and both TF and PAR2 genes.

Chemotherapeutic potential of radotinib against blood and solid tumors: A beacon of hope in drug repurposing.

Tyrosine kinase inhibitors (TKIs) represent a pivotal class of targeted therapies in oncology, with multiple generations developed to address diverse molecular targets. Imatinib is the first TKI developed to target the BCR-ABL1 chimeric protein, which is the key driver oncogene implicated in Philadelphia chromosome-positive chronic myeloid leukemia (CML). Several second-generation tyrosine kinase inhibitors (2GTKIs), such as nilotinib, dasatinib, bosutinib, and radotinib (RTB), followed the groundbreaking introduction of imatinib.