Benign Adult-Type Osteopetrosis with Recurrent Osteomyelitis of the Maxilla-A Rare Case Report.

Osteopetrosis, also known as marble bone disease, is a genetic condition characterised by generalised sclerosis of bones. The osteoclastic cells responsible for bone resorption are defective and nonfunctional. These patients tend to have low bone quality in spite of increased bone deposition and thus experience multiple fractures during their life span.

Candida Albicans Candidalysin ECE1 Gene - A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders.

Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans).

Network Pharmacology-driven therapeutic interventions for Interstitial Lung Diseases using Traditional medicines: A Narrative Review.

This review explores the progressive domain of network pharmacology and its potential to revolutionize therapeutic approaches for Interstitial Lung Diseases (ILDs), a collective term encompassing Interstitial Pneumonia, Pneumoconiosis, Connective Tissue Disease-related ILDs, and Sarcoidosis. The exploration focuses on the profound legacy of traditional medicines, particularly Ayurveda and Traditional Chinese Medicines (TCM), and their largely unexplored capacity in ILD treatment. These ancient healing systems, characterized by their holistic methodologies and multifaceted treatment modalities, offer a promising foundation for discovering innovative therapeutic strategies.

A case of assisted reproductive technology-induced maternal alloimmunization: an emerging sensitizing factor to consider?

Red blood cell (RBC) alloimmunization can occur because of exposure to various sensitizing factors and poses a constant threat in transfusion. Assisted reproductive technology (ART) involves manipulation of sperm, ova, or embryos with the goal of producing a pregnancy. We present an interesting case of ART-induced maternal alloimmunization (AIMA) due to anti-c in a woman carrying a twin pregnancy.

Exploration of the Reasons for Poor Adherence Among Metabolic Syndrome Patients Attending a Tertiary Care Hospital in Tamil Nadu, India: A Mixed Method Study.

Background A major challenge in the treatment of MetS is the prevalence of low rates of adherence to the treatment regimen for individual components by the affected persons. This study aimed to estimate the medication adherence level among those with metabolic syndrome, determine the factors significantly associated with low adherence to medication, and explore the reasons for poor adherence to medication Materials and methods This sequential explanatory type of mixed method study was conducted among the metabolic syndrome patients attending the lifestyle clinic of a tertiary care hospital in the Salem district of Tamil Nadu, India. For the quantitative component, 210 was the sample size and for the qualitative component, the sample size was six.

Anatomical Insights: Two Case Reports on Protostylid Variants and Literature Synthesis.

Protostylids are an anatomical variant of the paramolar tubercle, which refers to the presence of an additional cusp in the buccal surfaces of maxillary and mandibular bicuspids and molars. This structure, first reported by Dahlberg in 1950, is found in low frequencies and plays a significant role in dental anthropology. This anatomical variant, if present poses a threat to dental caries and periodontal diseases and hence requires early diagnosis and preventive dental care.

Respiratory symptoms and pulmonary function in paint industry workers exposed to volatile organic compounds: A systematic review and meta-analysis.

Several epidemiological studies have examined the respiratory consequences of occupational exposure to volatile organic compounds (VOCs). However, their effects on paint industry workers in organised and unorganised occupational sectors vary. The present systematic review and meta-analysis aim at evaluating the respiratory symptoms and pulmonary function of paint industry workers from various occupational sectors exposed to VOCs.

Special Techniques of Liver Transplantation: Living Donor Liver Transplantation With Right Posterior Sector Grafts and Extended Left Lobe Grafts; Auxiliary Partial Orthotopic Liver Transplantation, and Dual-Lobe Liver Transplantation.

Living donor liver transplantation (LDLT) constitutes the majority of liver transplants in Asia and advancements in LDLT techniques have expanded the range of allografts beyond the commonly used right lobe (RL). This review provides a comprehensive overview of lesser-known variants of allografts and LDLT techniques which include right posterior sector grafts (RPSG), dual-lobe liver transplantation (DLLT), auxiliary partial orthotopic liver transplantation (APOLT), and extended left lobe grafts with caudate concentrating on the technical aspects, current evidence, and their indications in contemporary practice of LDLT. The first section examines RPSGs, focussing on their potential as an alternative to RL grafts particularly when volumetric studies indicate a larger right posterior sector in donors.

Clock-Sleep Communication.

Rhythmicity is a characteristic feature of the inanimate universe. The organization of biological rhythms in time is an adaptation to the cyclical environmental changes brought on by the earth's rotation on its axis and around the sun. Circadian (L.

Non-Ionic Surfactant Vesicles (Niosomes): Structure, Functions, Classification and its Advances in Enhanced Drug Delivery.

Non-ionic surfactant vesicles, commonly known as niosomes, have gained significant attention in the field of drug delivery because of their unique properties and advantages. Niosomes are self-assembled vesicles composed of non-ionic surfactants and cholesterol that can entrap both hydrophilic and hydrophobic drugs within their aqueous core or bilayer. This versatile drug delivery system offers improved stability, prolonged release profiles, reduced toxicity, and enhanced efficacy for a wide range of therapeutic agents.

Functional outcome of anterior cruciate ligament reconstruction with hamstring tendon autograft in Indian population: A systematic review and meta-analysis.

Background: Anterior cruciate ligament (ACL) injury is a significant orthopedic issue globally with varying success rates among different populations. Better understanding of functional outcome can help design suitable protocols for ACL reconstruction and recovery. This review aims to evaluate the epidemiological trends and functional outcomes of ACLR procedures in India.

Prevalence of Nutritional Anaemia in Type 2 Diabetes Mellitus in the Absence of Renal Impairment.

Background: Anemia is more common in people with type 2 diabetes mellitus (T2DM) and is more likely when glycemic control is poor. Anemia in T2DM can reduce quality of life and increase cardiovascular risk, and therefore, its prevalence and contributory factors in diabetic patients with normal kidney function are important to understand.

Aim And Objectives: The aim of this study is to assess the prevalence of anemia in individuals with type 2 diabetes and normal kidney function, focusing on blood glucose, serum creatinine, HbA1c, hemoglobin, and hematocrit levels.

Parental Experiences on Learning About and Caring for Children with Cleft Lip and Palate: A Qualitative Study from South India.

Objectives: The study aimed to understand parents' reactions to cleft, the manner in which they learned about its presence, and the challenges they faced in caring for their child with a view to providing healthcare professionals insights toward enhancing care delivery.

Design: Qualitative in-depth interviews using the grounded theory approach were carried out with 11 mothers and fathers of children with cleft lip and palate (CLP) attending a cleft speciality hospital in Chennai city, in South India.

Results: Analysis resulted in the discovery of 5 core categories, learning about CLP-when and how, reactions and attributions to CLP, learning about and expectations from treatment, caring for a child with CLP and support systems.

Empowering Precision Oncology: Advancing Cancer Research by Augmenting Single-cell RNA and Bulk RNA Sequencing for Confronting the Heterogeneity in Ovarian Cancer.

Ovarian cancer presents significant challenges in clinical oncology due to its high prevalence, heterogeneity, and late-stage diagnosis. Our study explores the application of single-cell RNA sequencing (scRNA-Seq) and bulk RNA sequencing to enhance our understanding of ovarian cancer at the molecular level. We highlight the diagnostic strategies and emphasize the critical role of scRNA-Seq in unraveling the intricate cellular composition and phenotypic plasticity within ovarian tumors.

A Remarkable Presentation of Phyllodes Tumor With Pseudoangiomatous Stromal Hyperplasia.

Phyllodes tumor is a rare and particular type of breast tumor with features of stromal hyperplasia and malignant potential. The present case is an unusual presentation of a phyllodes tumor with pseudoangiomatous stromal hyperplasia (PASH) which forms an essential part of benign breast disease but is not frequently described in association with phyllodes tumor. A 36-year-old female patient was referred to the hospital with a large breast mass considered to be a benign growth.

The Relationship Between Anthropometric Indices of Obesity and Sleep Disturbances in Young Adults.

Background: Sleep is vital for maintaining overall health and influencing various physiological and psychological processes. Disruptions in sleep quality are linked to adverse health outcomes, including obesity and cardiovascular disease, particularly among young adults who are often exposed to stress and lifestyle changes. This study investigates the relationship between anthropometric indices of obesity measured through body mass index (BMI), waist-to-hip ratio (WHR), and waist circumference (WC) and sleep disturbances in young adults.

Designing potential lead compounds targeting aminoglycoside N (6')-acetyltransferase in Serratia marcescens: A drug discovery strategy.

Serratia marcescens is an opportunistic human pathogen that causes urinary tract infections, ocular lens infections, and respiratory tract infections. S. marcescens employs various defense mechanisms to evade antibiotics, one of which is mediated by aminoglycoside N-acetyltransferase (AAC).

Metastatic colorectal adenocarcinoma of mandible.

Oral metastasis from the colon is quite rare with limited reporting and scientific evidence. The most common metastasis from colorectal cancer is to the liver followed by lungs, bones, and other organs. However rare occurrences like metastasis to the oral cavity might worsen the prognosis and treatment outcome.

Trailblazer in Health Education: The Legacy of Thomas Denison Wood.

Thomas Denison Wood, often regarded as the "Father of Health Education," was a pioneering figure in the early 20th century whose work laid the foundation for modern health education. His contributions were instrumental in integrating health education into the public school curriculum in the United States. Wood advocated for a holistic approach to health, encompassing physical fitness, hygiene, nutrition, mental health, and preventive care.

Expanding Opportunities for Living Donation: Recommendations From the 2023 Santander Summit to Ensure Donor Protections, Informed Decision Making, and Equitable Access.

A strategic vision toward global convergence in transplantation must encourage and remove barriers to living organ donation and transplantation. Here, we discuss deliberations of a working group of the 2023 Santander Summit charged with formulating recommendations for the safe expansion of living donor kidney transplantation and living donor liver transplantation worldwide. Living donor kidney transplantation has grown to be the preferred treatment for advanced kidney failure.

Reinforcing Global Oversight of Organ Transplantation: Activity and Outcome Monitoring Through the Development of Registries.

Establishing transparency and oversight of organ transplantation by regulatory agencies is of paramount importance to assure ethical, legal, and clinically robust transplantation practices. Registries reporting activity and outcome data of the donor and recipient, including donor source (living or deceased), must be developed for each transplant and should be a mandatory requirement to achieve accreditation to perform transplant surgeries. Collected data for the living organ donor must include the nationality, the nature of their relationship with the recipient, and the complications encountered by living donors that result in prolonged morbidity or mortality.