Dual nitrogen and phosphorus reductions are needed for long-term mitigation of eutrophication and harmful cyanobacterial blooms in the hydrologically-variable San Francisco Bay Delta, CA.

Cyanobacterial harmful algal blooms (CyanoHABs) are a major concern for water quality, public health and viability of aquatic ecosystems. Increased inputs of nutrients, i.e.

Protective effects of long term antiplatelet and anticoagulant therapy in hospitalized patients with inflammatory bowel disease.

Background: Inflammatory bowel disease (IBD), with its rising prevalence rates is associated with an increased risk of cardiovascular and thromboembolic events. Antiplatelets and/or anticoagulants agents are often prescribed but the literature on the impact of long-term anticoagulation and/or antiplatelet use among patients hospitalized with IBD is scarce. The aim of this study is to assess the outcomes of patients hospitalized with IBD on antiplatelet and/or anticoagulant agents.

Pediatric Orthopaedic Surgeons Manage Pediatric Diaphyseal Clavicle Fractures Differently Than Nonpediatric Orthopaedic Specialists.

Background: Pediatric clavicle fractures are often managed by physicians with and without pediatric subspecialty training. The aim of this study is to identify if variability of practice exists between pediatric orthopaedic surgeons versus nonpediatric orthopaedic specialists during management of pediatric diaphyseal clavicle fractures.

Methods: Patients ≤18 years of age with an acute, closed diaphyseal clavicle fracture treated between January 2018 and July 2023 by a large hospital-employed multispecialty orthopaedic practice (in a regional and academic health network) were retrospectively reviewed.

Design of an atomic layer deposition system with in situ reflection high energy electron diffraction.

We report the design, fabrication, and testing of an atomic layer deposition (ALD) system that is capable of reflection high energy electron diffraction (RHEED) in a single chamber. The details and specifications of the system are described and include capabilities of RHEED at varied accelerating voltages, sample rotation (azimuthal) control, sample height control, sample heating up to set temperatures of 1050 °C, and either single- or dual-differential pumping designs. Thermal and flow simulations were used to justify selected system dimensions as well as carrier gas/precursor mass flow rates.

Satellite-Derived, Smartphone-Delivered Geospatial Cholera Risk Information for Vulnerable Populations.

Cholera, an acute waterborne diarrheal disease, remains a major global health challenge. Despite being curable and preventable, it can be fatal if left untreated, especially for children. Bangladesh, a cholera-endemic country with a high disease burden, experiences two peaks annually, during the dry pre-monsoon spring and the wet post-monsoon fall seasons.

Lymphadenectomy for Gastric Cancer.

Current treatment for gastric cancer includes a multidisciplinary approach of systemic therapy and surgery. While retrospective, prospective, and randomized trials have demonstrated conflicting results on the need for extended lymphadenectomy, current guidelines dictate a recommendation for the retrieval of at least 16 lymph nodes to accurately stage patients. The "D1" lymph nodes along the major gastric and epiploic vessels may provide adequate lymph node harvest, though "D2" lymphadenectomy along the celiac axis and its branches may be necessary.

Prognostic bone fracture healing simulations in an ovine tibia model validated with in vivo sensors.

Bone fracture healing is a complex physiological process influenced by biomechanical and biomolecular factors. Mechanical stability is crucial for successful healing, and disruptions can lead to delayed healing or nonunion. Bone commonly heals itself through secondary fracture healing, which is governed by the mechanical strain at the fracture site.

The Relationship Between Professional Quality of Life and Work Environment Among Nurses in Intensive Care Units.

Nurses in intensive care units (ICUs) face high levels of stress and emotional challenges, making it essential to understand the factors that influence their professional quality of life (ProQoL). This study aimed to investigate the relationship between work environment factors and ProQoL, particularly focusing on burnout, compassion satisfaction, and secondary traumatic stress, among ICU nurses. The Professional Quality of Life (ProQoL) Scale was used to measure these aspects, with an emphasis on the importance of a supportive work environment for enhancing staff well-being and organizational performance.

Subsequent pregnancies in peripartum cardiomyopathy: Patient-level differences and decision-making.

Study Objective: To evaluate patient-level differences and decision making surrounding subsequent pregnancies (SSP) after peripartum cardiomyopathy (PPCM).

Design: Mixed methods approach to evaluate quantitative demographic and clinical differences between patients with and without a SSP and to qualitatively describe the decision-making regarding a SSP with a survey component.

Setting/participants: 220 PPCM cases within the University of Pennsylvania Health System.

Knee dislocation with concomitant patellofemoral dislocation: A systematic review.

Background: There is no consensus treatment for knee dislocations with associated patellar dislocation. This systematic review provides an overview of current treatments and the authors preferred treatment algorithm. Knee dislocation with concomitant patellar dislocation is a rare occurrence and there is no standard of care for these injuries.

A complex case of disseminated histoplasmosis triggering hemophagocytic lymphohistiocytosis in a patient with lupus.

Disseminated histoplasmosis is a rare yet serious fungal infection that primarily affects individuals with compromised immune systems. While it is widely known for its endemicity in the Midwest region of the USA, recent studies have indicated a noteworthy increase in sporadic cases, suggesting a widening of the endemic region for the pathology. This report describes a case of disseminated histoplasmosis in a 39-year-old female with a history of lupus, hypertension, anxiety, asthma, idiopathic edema, and fibromyalgia from a nonendemic region, who presented with cyclic fevers of unknown origin, peripheral edema, and oral sores.

Discovery of deep-sea coral symbionts from a novel clade of marine bacteria with severely reduced genomes.

Microbes perform critical functions in corals, yet most knowledge is derived from the photic zone. Here, we discover two mollicutes that dominate the microbiome of the deep-sea octocoral, Callogorgia delta, and likely reside in the mesoglea. These symbionts are abundant across the host's range, absent in the water, and appear to be rare in sediments.

Ca-dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion.

Robust coordination of surface and volume changes is critical for cell integrity. Few studies have elucidated the plasma membrane (PM) remodeling events during cell surface and volume alteration, especially regarding PM sensing and its subsequent rearrangements. Here, using fission yeast protoplasts, we reveal a Ca-dependent mechanism for membrane addition that ensures PM integrity and allows its expansion during acute hypoosmotic cell swelling.

Defining myocardial fiber bundle architecture in atrial digital twins.

A key component in developing atrial digital twins (ADT) - virtual representations of patients' atria - is the accurate prescription of myocardial fibers which are essential for the tissue characterization. Due to the difficulty of reconstructing atrial fibers from medical imaging, a widely used strategy for fiber generation in ADT relies on mathematical models. Existing methodologies utilze semi-automatic approaches, are tailored to specific morphologies, and lack rigorous validation against imaging fiber data.

Amyotrophic lateral sclerosis established as a multistep process across phenotypes.

Background And Purpose: Given the accepted multistep process of disease causation in amyotrophic lateral sclerosis (ALS), the present study was undertaken to determine the number of steps required for disease onset across each of the ALS phenotypes.

Methods: Clinical and demographic data were prospectively accumulated using the Australian Motor Neurone Disease Registry (2005-2016), and age-specific incidence rates were calculated. Poisson regression was utilized to assess the relationship between log age-specific incidence and log age of onset, with McFadden's R used to assess the goodness of fit of the model.

Enhanced Thermodynamic Stability of Delithiated Nano-LiCoO by Lanthanum Doping.

The dynamic environment within lithium-ion batteries induces significant changes in local thermodynamic functions, hampering the accurate prediction of the stability of the cathodes during cycling. While delithiation primarily affects the surface properties of the cathode structure, there is a lack of fundamental understanding concerning the evolution of interfacial energies with varying stoichiometry. Here, we used microcalorimetry to quantify the thermodynamic changes between the stoichiometric and partially delithiated nano-LiCoO states for the first time.

Identification of a novel neutralization epitope in rhesus AAVs.

Adeno-associated viruses (AAVs) are popular gene therapy delivery vectors, but their application can be limited by anti-vector immunity. Both preexisting neutralizing antibodies (NAbs) and post-administration NAbs can limit transgene expression and reduce the clinical utility of AAVs. The development of novel AAVs will advance our understanding of AAV immunity and may also have practical applications.

Interpretable Spatio-Temporal Embedding for Brain Structural-Effective Network with Ordinary Differential Equation.

The MRI-derived brain network serves as a pivotal instrument in elucidating both the structural and functional aspects of the brain, encompassing the ramifications of diseases and developmental processes. However, prevailing methodologies, often focusing on synchronous BOLD signals from functional MRI (fMRI), may not capture directional influences among brain regions and rarely tackle temporal functional dynamics. In this study, we first construct the brain-effective network via the dynamic causal model.

The reference value of serum vitamin B12 among An-Najah National University.

Background: Serum vitamin B12 plays a crucial role in cellular growth, DNA synthesis, and maintaining a healthy nervous system. Its deficiency can lead to various health issues, including cardiovascular problems. The reference range for vitamin B12 varies between populations due to cultural, genetic, and dietary differences.

Physicochemical Properties of Seed Oil Blends and Their Potential for the Creation of Synthetic Oleosomes with Modulated Polarities.

There is an increasing demand within the pharmaceutical and cosmetic industries for biofriendly lipid-based active ingredient delivery systems. Micelles, liposomes, and lipid nanoparticles are currently the most used systems despite their limitations. Oleosomes, also known as lipid droplets, are promising alternatives to the existing strategies.