Microdroplet Resuspension Off Surfaces.

Understanding the resuspension of droplets from surfaces into air is important for elucidating a range of processes such as disease transmission of airborne pathogens and determining environmental contamination and the effectiveness of cleaning procedures. The resuspension condition is defined as the escape velocity of a droplet from a surface. This study investigated the dynamics of microliter-sized droplet resuspension off surfaces utilizing a novel free-fall device.

TP53 missense allele predisposing to high risk of breast cancer but not pediatric cancers.

Pathogenic TP53 germline variants cause young-onset breast cancer and other cancers of the Li-Fraumeni syndrome (LFS) spectrum, but the clinical consequences of partial-loss-of function TP53 variants are incompletely understood. In the consecutive cohort of Palestinian breast cancer patients of the Middle East Breast Cancer Study (MEBCS), breast cancer risk among TP53 p. R181C heterozygotes was 50% by age 50 y and 81% by age 80 y.

Exploring Burnout and Leadership Mitigation Plans in Academic Nursing Environments.

Background: Staff burnout in higher education may affect nursing department functionality. There is limited literature regarding staff burnout and its manifestations in nursing colleges and schools.

Purpose: This study evaluated academic nurse leaders' perceptions of burnout and mitigation strategies in colleges and schools of nursing.

1-Year Real-World Outcomes of TAVR With the Fifth-Generation Balloon-Expandable Valve in the United States.

Background: Longer term outcomes of transcatheter aortic valve replacement (TAVR) with the SAPIEN 3 Ultra RESILIA (S3UR) valve over its predecessors have not been reported in a national registry.

Objectives: The aim of this study was to compare the 1-year clinical and echocardiographic outcomes of the S3UR with those of the SAPIEN 3 (S3) and SAPIEN 3 Ultra (S3U) in the Society of Thoracic Surgeons/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry.

Methods: From September 2022 to March 2023, patients who underwent native TAVR with the S3UR or the S3 or S3U valve were propensity matched and compared.

Expanding the Reaction Network of Ethylene Epoxidation on Partially Oxidized Silver Catalysts.

An extended microkinetic model (MKM) for the selective oxidation of ethylene to ethylene oxide (EO) is presented, based on an oxidic representation of the silver (Ag) surface, namely, the p(4 × 4) oxidic reconstruction of the Ag(111) phase to mimic the significant oxygen coverage under reaction conditions, as is evidenced by recent operando spectroscopic studies. The MKM features three pathways each for producing either ethylene oxide (EO) or carbon dioxide (CO), including the common intermediate or oxometallacycle (OMC) pathway, an atomic oxygen pathway, as well as pathways centered around the role of a diatomic oxygen species occupying an oxygen vacancy (O/O*). The MKM uses a composite set of experimental and density functional theory (DFT) kinetic parameters, which is further optimized and trained on experimental reaction data.

Percutaneous Biopsy and Drainage of the Pancreas.

Percutaneous biopsy and drainage of pancreatic lesions, though less frequent due to advancements in endoscopic techniques, remain vital skills for interventional radiologists. This review details the indications, options, approaches, and technical considerations for pancreatic biopsy and (peri)pancreatic fluid drainage by examining a comprehensive range of literature. The importance of a multidisciplinary approach is emphasized to ensure optimal patient care and outcomes, highlighting current best practices and recent advancements.

"We Were Just so Sad and Devastated": NICU Nurses' Stories of Caring for Families With Substance-Exposed Pregnancies.

This secondary analysis re-examined stories of caregiving told by NICU nurses in the southeast US through a trauma theory lens expanding on research surrounding substance-exposed pregnancies. Narrative analysis identified distress-related experiences of nurses related to child custody decisions and outcomes, suggesting traumatic stress within this caregiving dynamic. Four distinct story types and three themes were identified across 23 stories, highlighting similarities and differences and illustrating how distress and trauma were experienced and may be manifested in care practices.

Adipose-Derived Stem Cells Prevent Anastomotic Leak: A Porcine Ischemic Esophagectomy Model.

Introduction: Esophagectomy is a lifesaving procedure plagued by an anastomotic leak rate of 11%-35%. Ischemia is widely accepted to be the most significant risk factor for anastomotic leak. We hypothesized that the injection of adipose-derived stem cells (ASCs) into an ischemic esophagogastric anastomosis would prevent leakage.

Coacervation for biomedical applications: innovations involving nucleic acids.

Gene therapies, drug delivery systems, vaccines, and many other therapeutics, although seeing breakthroughs over the past few decades, still suffer from poor stability, biocompatibility, and targeting. Coacervation, a liquid-liquid phase separation phenomenon, is a pivotal technique increasingly employed to enhance the effectiveness of therapeutics. Through coacervation strategies, many current challenges in therapeutic formulations can be addressed due to the tunable nature of this technique.

The Relationship Between Quality of Life and Social Support Among Pregnant Women: A Cross-Sectional Study.

Introduction: Pregnant women require social support and healthcare treatments that are specifically designed to address their quality of life (QoL) during this time, as this will help them get through this crucial stage with more resilience and comfort.

Objective: This study aimed to assess the relationship between the QoL of pregnant women and social support.

Methods: A cross-sectional study was conducted involving 423 pregnant women.

Enhancing Tracheostomy Care: Knowledge Among Nurses in Intensive Care Units.

Patients requiring continuous mechanical ventilation benefit from easier airway management through tracheostomy, a standard treatment in critical care. However, gaps in nurses' comprehension of tracheostomy car can lead to complications such as infections and airway blockages. Therefore, understanding nurses' competency in tracheostomy care is essential for enhancing patient outcomes in intensive care units (ICUs).

Polythiophene side chain chemistry and its impact on advanced composite anodes for lithium-ion batteries.

In the development of high-performance lithium-ion batteries (LIBs), the design of polymer binders, particularly through manipulation of side-chain chemistry, plays a pivotal role in optimizing electrode stability, ion transport, and adaptability to the volume changes during cycling. In particular, poly[3-(potassium-4-butanoate)thiophene-2,5-diyl] (P3KBT) increases magnetite and silicon capacity and cycling stability. This work explores the impact of polythiophene alkyl sidechain length on anode characteristics, aiming to enhance performance in LIBs.

Controlling Ion Uptake in Carboxylated Mixed Conductors.

Organic mixed ionic-electronic conductors (OMIECs) have garnered significant attention due to their capacity to transport both ions and electrons, making them ideal for applications in energy storage, neuromorphics, and bioelectronics. However, charge compensation mechanisms during the polymer redox process remain poorly understood, and are often oversimplified as single-ion injection with little attention to counterion effects. To advance understanding and design strategies toward next-generation OMIEC systems, a series of p-channel carboxylated mixed conductors is investigated.

Predicting Long-Term Mortality Using American College of Cardiology (ACC)/American Heart Association (AHA) Pooled Cardiovascular Risk Cohort Equations: Implications for Lipid-Lowering Therapy.

Introduction: Primary prevention statin therapy is initiated based on the 10-year ASCVD risk estimated by the pooled cohort equations (PCEs), with treatment effectiveness monitored through low-density lipoprotein cholesterol levels. It remains uncertain whether ASCVD risk accurately predicts the mortality impact of lipid-lowering therapy. This study aims to assess the predictive performance of the PCE for mortality with and without lipid-lowering therapy and the mortality impact of lipid-lowering therapy with similar ASCVD risk.

Nuclear eDNA metabarcoding primers for anthozoan coral biodiversity assessment.

The distributions of anthozoan corals are undercharacterized due to their wide bathymetric ranges, occurrences in remote locales, and difficulties of identification from morphology alone. Environmental DNA (eDNA) sequencing promises to be a noninvasive strategy to complement conventional approaches for mapping and monitoring the distribution and biodiversity of coral communities. Primers for eDNA metabarcoding have been designed to amplify nuclear and mitochondrial DNA barcodes in shallow scleractinians and mitochondrial in deep-sea octocorals.

Magma Chamber Response to Ice Unloading: Applications to Volcanism in the West Antarctic Rift System.

Volcanic activity has been shown to affect Earth's climate in a myriad of ways. One such example is that eruptions proximate to surface ice will promote ice melting. In turn, the crustal unloading associated with melting an ice sheet affects the internal dynamics of the underlying magma plumbing system.

Project G-SPACE: protocol for exploring the influence of green space on sleep and mental health among children.

Background: The prevention of pediatric mental health disorders is a growing health priority in the United States. While exposure to green space, such as outdoor vegetation, has been linked with improved mental health outcomes in children, little is known about the impact of green space on children's sleep. Sleep has many benefits, but the factors affecting both sleep and mental health as they relate to green space exposure are not well understood in children.

Development of venous thromboembolic event risk calculator for metabolic and bariatric surgery patients to reduce mortality.

Background: Venous Thromboembolic events (VTE) after Metabolic and Bariatric Surgery (MBS) result in significant morbidity and are the leading cause of mortality.

Objective: The objective of this study was to identify patients who are at a high risk for developing VTE and who may benefit from extended chemoprophylaxis following MBS.

Setting: Multi-institutional study.