517 results match your criteria: "Bethesda-Hospital[Affiliation]"

Introduction: Concentration of trauma care in trauma network has resulted in different trauma populations across designated levels of trauma care.

Objective: Describing psychological health status, by means of the impact event scale (IES) and the hospital anxiety and depression scale (HADS), of major trauma patients one and two years post-trauma across different levels of trauma care in trauma networks.

Methods: A multicentre retrospective cohort study was conducted.

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Background: As one of the most common non-communicable diseases in Africa, Stroke ought to be dealt with properly with intensifying efforts to control its burden and to face obstacles in its management.

Methods And Results: In this follow-up study we reanalyzed stroke services and related obstacles in 17 African countries that were previously studied in 2021/22 in aspects related to manpower, acute stroke services, rehabilitation programs, number of stroke units/centers, telestroke services, awareness campaigns, and national and international stroke registries through a survey that was sent to stroke specialists and national stroke societies. Overall, there is an improvement in many fields yet many obstacles in the implementation of telestroke services, acute management, secondary prevention, post-discharge services, and follow-ups whether governmental, medical, or societal are prevalent.

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Safety and Efficacy of Infusional Perioperative Tacrolimus Therapy in Crohn's Disease Patients Undergoing Intestinal Resection.

Inflamm Intest Dis

November 2024

Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital Marburg, Philipps University Marburg, Marburg, Germany.

Introduction: Perioperative optimization of Crohn's disease (CD) patients is mandatory in order to ensure favorable outcomes and limit perioperative morbidity such as anastomosis-related complications. The use of perioperative tacrolimus may offer beneficial inflammatory control and improve postoperative outcome. However, it also may exhibit unwanted effects of immunosuppression on infectious complications and wound healing.

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Objective: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune neuropathy characterized by progressive or relapsing-remitting weakness and sensory deficits. This study aims to evaluate the utility of corneal confocal microscopy (CCM) in diagnosing and monitoring CIDP.

Methods: We analysed 100 CIDP patients and 31 healthy controls using CCM to measure corneal nerve fiber density (CNFD), length (CNFL), and branch density (CNBD).

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A bird-eye view of diaphragmatic endometriosis: current practices and future perspectives.

Front Med (Lausanne)

November 2024

Department of Obstetrics, Gynecology, Gynecologic Oncology and Senology, Bethesda Hospital Duisburg, Duisburg, Germany.

Diaphragmatic endometriosis is one of the most common localization of extra-pelvic endometriosis and may cause debilitating symptoms such as cyclic shoulder pain, right upper abdominal pain, and right-sided chest pain. Diaphragmatic endometriosis may also be asymptomatic. The exact mechanisms by which diaphragmatic endometriosis originates are unknown.

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To assess the cost-effectiveness of low-dose aspirin compared to placebo for the prevention of recurrent preterm birth from a healthcare perspective. This was a cost-effectiveness analysis alongside a multicenter, randomized, double-blinded, placebo-controlled trial. We included women with a singleton pregnancy and a previous spontaneous preterm birth <37 weeks of gestation of a singleton.

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Article Synopsis
  • Cystoscopy has long been the main method for detecting urothelial carcinoma (UCa), but its invasiveness and costs highlight the need for non-invasive detection methods, leading to the investigation of urinary biomarkers.
  • In a study involving 1,119 urine samples, researchers analyzed protein levels of biomarkers CXCL16 and TGFBI, along with DNA methylation at specific CpG sites, to assess their ability to identify UCa compared to other urological and gynecological cancers.
  • Results showed that while CXCL16 and TGFBI had moderate sensitivity (31% and 56%) and high specificity (94% and 85%), combining these proteins and methylation markers improved UCa detection sensitivity to 54%
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As part of efforts to reach the elimination target by 2030, the WHO and CDC recommend that all HCWs adhere to the three-dose Hepatitis B vaccination schedule to protect themselves against the infection. This study assessed Hepatitis B vaccination coverage and associated factors among personnel working in health facilities in Kumasi, Ashanti Region, Ghana. A cross-sectional study involving 530 HCWs was conducted in four hospitals in Kumasi from September to November 2023.

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Sex-based differences in physical and psychological recovery, and return to sport, following anterior cruciate ligament reconstruction.

Knee

January 2025

School of Human Sciences (Exercise and Sport Science), University of Western Australia, Perth, Western Australia; Orthopaedic Research Foundation of Western Australia, Perth, Western Australia; Perth Orthopaedic & Sports Medicine Research Institute, Perth, Western Australia; HFRC, Perth, Western Australia. Electronic address:

Article Synopsis
  • - This study examined differences in recovery between males and females after anterior cruciate ligament reconstruction (ACLR) focusing on physical and psychological aspects as well as return to sport (RTS) rates.
  • - Results showed that males had better recovery scores on measures like the ACL-RSI and the IKDC, with a higher percentage returning to pivoting sports compared to females at 24 months post-operation.
  • - Overall, females exhibited lower physical performance, subjective function, and psychological readiness for RTS, highlighting a need for tailored recovery strategies based on sex.
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  • Surgical removal of deep endometriosis lesions can relieve symptoms but often causes problematic adhesions; this study evaluates a new hyaluronic acid gel designed to reduce those adhesions after surgery.
  • Conducted on 60 patients, the study analyzed inflammation, pain, and complications within 72 hours after laparoscopic surgery, indicating a slight increase in inflammatory markers post-surgery yet no serious adverse events.
  • Findings suggest that the antiadhesion gel (HyaRegen) is safe for managing inflammatory responses after surgery, with manageable pain levels reported by over 60% of participants.
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Article Synopsis
  • A new coronavirus disease called SARS-CoV-2 emerged in 2019, leading to an ongoing pandemic with variable symptoms and complications affecting blood cell production and clotting.
  • Four COVID-19 vaccines were released in 2020, but some were linked to hematological issues like vaccine-induced immune thrombotic thrombocytopenia (VITT) and immune thrombocytopenic purpura (ITP).
  • This case report discusses two patients who developed ITP after receiving the AstraZeneca vaccine, showing a positive response to treatment with thrombopoietin-receptor agonists, highlighting the need for clearer treatment guidelines for vaccination-related blood disorders.
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Educational outcomes of simulation-based training in regional anaesthesia: a scoping review.

Br J Anaesth

October 2024

Department of Anesthesiology and Pain Medicine, Ottawa Hospital Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Background: Structured training in regional anaesthesia includes pretraining on simulation-based educational platforms to establish a safe and controlled learning environment before learners are provided clinical exposure in an apprenticeship model. This scoping review was designed to appraise the educational outcomes of current simulation-based educational modalities in regional anaesthesia.

Methods: This review conformed to PRISMA-ScR guidelines.

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Assessing bowel perfusion in emergency intestinal surgery can prove challenging even for experienced surgeons. The necessity of a technological tool assisting clinicians is undisputed. Near-infrared indocyanine green (NIR-ICG) angiography has been increasingly used in elective colorectal surgery to evaluate intestinal perfusion with promising results.

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Artificial intelligence in pathologic diagnosis, prognosis and prediction of prostate cancer.

Am J Clin Exp Urol

August 2024

Department of Computational Pathology, NovinoAI 1443 NE 4th Ave, Fort Lauderdale, FL 33304, USA.

Histopathology, which is the gold-standard for prostate cancer diagnosis, faces significant challenges. With prostate cancer ranking among the most common cancers in the United States and worldwide, pathologists experience an increased number for prostate biopsies. At the same time, precise pathological assessment and classification are necessary for risk stratification and treatment decisions in prostate cancer care, adding to the challenge to pathologists.

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Article Synopsis
  • - This study investigates the incidence of delayed intracranial hemorrhage (ICH) in older patients (65+) who suffered head trauma and were on anticoagulant medications, noting that delayed ICH rates post-injury range widely in existing literature.
  • - Conducted across two emergency departments with 3,425 enrolled patients, the findings showed a very low incidence of delayed ICH at 0.4%, and no significant difference in rates between patients on anticoagulants and those not on them.
  • - The results suggest that delayed ICH is uncommon in this population, which could influence clinical decision-making and management strategies for geriatric patients with blunt head trauma.
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Introduction: Preoperative botolinum toxin A (BTA) administration to the lateral abdominal wall has been widely used since its introduction for treating complex abdominal wall defects and loss of domain (LOD) hernias. Intraoperative fascial traction (IFT) is an established technique for complex abdominal wall hernias exceeding a width of 10 cm and has also shown auspicious results. We present our single center data including 143 consecutive cases combining both techniques from 2019 to 2023.

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The value of perforator flap reconstruction in painful soft tissue calcifications.

Clin Exp Med

August 2024

Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Reconstructive Basel, Switzerland.

Soft tissue calcifications frequently cause debilitating pain and functional impairments, considerably affecting patients' quality of life. As they are rare entities, evidence remains sparse, especially regarding treatment effectiveness and recurrence rates. While both pharmacological and surgical treatments may alleviate symptoms, complete resection is currently believed to prevent long-term recurrence of deposits.

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Article Synopsis
  • Pilonidal sinus disease, commonly treated in the Netherlands with excision and secondary healing, has high recurrence rates and poor healing, leading to the exploration of the Bascom cleft lift as an alternative with better outcomes.
  • A study compared healing success, time to heal, complications, and recurrence rates between the two techniques in 272 patients, revealing that Bascom cleft lift had significantly better healing rates (84.4% vs. 32.6%) and faster healing times (55 days vs. 101 days).
  • Although Bascom cleft lift showed a higher rate of complications (28.9% vs. 13.2%), it resulted in lower recurrence rates (6
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Objectives: Falls are common in adults aged 65 years and older and are the leading cause of traumatic brain injuries in this age group. Alcohol use may increase the risk of falls as well as the severity of resultant injuries. The aim of this study was to examine the association between self-reported alcohol use and the prevalence of intracranial hemorrhage (ICH) in this patient group.

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Astaxanthin and improvement of dementia: A systematic review of current clinical trials.

Cereb Circ Cogn Behav

June 2024

Faculty of Medicine, Duta Wacana Christian University/ Department of Neurology, Bethesda Hospital, Yogyakarta, Indonesia.

Article Synopsis
  • Worldwide, the rise in neurodegenerative diseases, particularly dementia, is linked to an aging population, prompting research into prevention methods like addressing oxidative stress and free radicals.
  • Astaxanthin, a marine carotenoid, has shown promise as a protective agent against cognitive decline in numerous animal model studies and is being evaluated in clinical trials involving older adults.
  • While statistical support is lacking, many trials reported both subjective and objective improvements in cognitive function with Astaxanthin supplementation, suggesting it could be beneficial for elderly individuals suffering from dementia.
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Article Synopsis
  • Medication non-adherence in COPD patients is a pressing issue, prompting interest in simpler treatment options like single-inhaler triple therapy (SITT) over multi-inhaler triple therapy (MITT) and the use of smart inhalers.
  • A literature review examining adherence levels between SITT and MITT found that most observational trials favored SITT for better adherence and clinical outcomes, while smart inhalers generally showed a positive but varied impact.
  • The TRICOLON trial is a planned study to further investigate the effectiveness of SITT and smart inhalers on improving adherence among COPD patients, involving 300 participants across ten hospitals.
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The Florida Geriatric Head Trauma CT Clinical Decision Rule.

J Am Geriatr Soc

September 2024

Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.

Background: Several clinical decision rules have been devised to guide head computed tomography (CT) use in patients with minor head injuries, but none have been validated in patients 65 years or older. We aimed to derive and validate a head injury clinical decision rule for older adults.

Methods: We conducted a secondary analysis of an existing dataset of consecutive emergency department (ED) patients >65 years old with blunt head trauma.

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Article Synopsis
  • This study focuses on chronic subdural hematoma (CSDH) treatment, specifically how a portion of patients can resolve their condition without surgery, despite standard treatment typically involving an operation.
  • Data were gathered from patients treated conservatively at three hospitals in the Netherlands, with a primary goal of identifying factors that allow patients to avoid further treatment within three months of diagnosis.
  • Results show that 73% of patients did not need additional treatment, often having smaller hematoma volumes, indicating that further research is necessary to determine which patients truly need surgery versus those who can be treated conservatively.
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