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46 results match your criteria: "Berne University Hospital and University of Berne[Affiliation]"
Front Immunol
February 2024
Department of Immunology, University Hospital Zurich (USZ), Zurich, Switzerland.
Background: Living donor (LD) kidney transplantation in the setting of ABO blood group incompatibility (ABOi) has been previously reported to be associated with increased risk for antibody-mediated rejection (ABMR). It is however unclear if the presence of pre-transplant donor specific antibodies (DSA) works as an additive risk factor in the setting of ABOi and if DSA positive ABOi transplants have a significantly worse long-term outcome as compared with ABO compatible (ABOc) DSA positive transplants.
Methods: We investigated the effect of pre-transplant DSA in the ABOi and ABOc setting on the risk of antibody-mediated rejection (ABMR) and graft loss in a cohort of 952 LD kidney transplants.
Front Immunol
March 2023
Department of Immunology, University Hospital Zurich (USZ), Zurich, Switzerland.
Introduction: The type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. Many centers are, therefore, reluctant to perform donor specific antibody (DSA) positive transplantations in the setting of donation after circulatory death (DCD). There are, however, no large studies comparing the impact of pre-transplant DSA stratified on donation type in a cohort with a complete virtual cross-match and long-term follow-up of transplant outcome.
View Article and Find Full Text PDFFront Immunol
October 2022
Department of Immunology, University Hospital Zurich (USZ), Zurich, Switzerland.
Background: Pre-transplant donor specific antibodies (DSA), directed at non-self human leukocyte antigen (HLA) protein variants present in the donor organ, have been associated with worse outcomes in kidney transplantation. The impact of the mean fluorescence intensity (MFI) and the target HLA antigen of the detected DSA has, however, not been conclusively studied in a large cohort with a complete virtual cross-match (vXM).
Methods: We investigated the effect of pre-transplant DSA on the risk of antibody-mediated rejection (ABMR), graft loss, and the rate of eGFR decline in 411 DSA positive transplants and 1804 DSA negative controls.
Biomed Pharmacother
October 2022
Cardiology, Cardiovascular Department, Lausanne University Hospital and University of Lausanne, Switzerland. Electronic address:
Aims: Hospitalization for heart failure treatment (HHF) is an incisive event in the course of HF. Today, the large majority of HHF patients is ≥ 65 years and discharge HF drugs are most often not applied at dose levels acknowledged to provide prognostic benefit. This study therefore aims to investigate the treatment effect size of discharge HF drugs in old HHF patients.
View Article and Find Full Text PDFTranspl Int
December 2021
Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
The aim of this study was to analyze first year renal outcomes in a nationwide prospective multicenter cohort comprising 2215 renal transplants, with a special emphasis on the presence of pre-transplant donor-specific HLA antibodies (DSA). All transplants had a complete virtual crossmatch and DSA were detected in 19% (411/2215). The investigated composite endpoint was a poor first-year outcome defined as (i) allograft failure or (ii) death or (iii) poor allograft function (eGFR ≤25 ml/min/1.
View Article and Find Full Text PDFMol Biol Evol
January 2018
Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland.
Pathogen strains may differ in virulence because they attain different loads in their hosts, or because they induce different disease-causing mechanisms independent of their load. In evolutionary ecology, the latter is referred to as "per-parasite pathogenicity". Using viral load and CD4+ T-cell measures from 2014 HIV-1 subtype B-infected individuals enrolled in the Swiss HIV Cohort Study, we investigated if virulence-measured as the rate of decline of CD4+ T cells-and per-parasite pathogenicity are heritable from donor to recipient.
View Article and Find Full Text PDFHIV Med
October 2017
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Objectives: Here we examined the hypothesis that some stable HIV-infected partnerships can be found in cohort studies, as the patients frequently attend the clinic visits together.
Methods: Using mathematical approximations and shuffling to derive the probabilities of sharing a given number of visits by chance, we identified and validated couples that may represent either transmission pairs or serosorting couples in a stable relationship.
Results: We analysed 434 432 visits for 16 139 Swiss HIV Cohort Study patients from 1990 to 2014.
Minerva Ginecol
April 2017
Department of Obstetrics and Gynecology, Bern University Hospital and University of Berne, Berne, Switzerland.
J Orthop Translat
January 2017
AO Research Institute Davos, Davos, Switzerland.
Background: One of the most serious adverse events potentially occurring during vertebroplasty is cement leakage. Associated risks for the patient could be reduced if cement filling is preoperatively planned. This requires a better understanding of cement flow behaviour.
View Article and Find Full Text PDFIntensive Care Med
June 2016
Department of Intensive Care Medicine, Berne University Hospital and University of Berne, Berne, Switzerland.
We propose an integrated and adaptable approach to improve patient care and clinical outcomes through analgesia and light sedation, initiated early during an episode of critical illness and as a priority of care. This strategy, which may be regarded as an evolution of the Pain, Agitation and Delirium guidelines, is conveyed in the mnemonic eCASH-early Comfort using Analgesia, minimal Sedatives and maximal Humane care. eCASH aims to establish optimal patient comfort with minimal sedation as the default presumption for intensive care unit (ICU) patients in the absence of recognised medical requirements for deeper sedation.
View Article and Find Full Text PDFClin Infect Dis
May 2016
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich.
Background: Drug resistance is a major barrier to successful antiretroviral treatment (ART). Therefore, it is important to monitor time trends at a population level.
Methods: We included 11 084 ART-experienced patients from the Swiss HIV Cohort Study (SHCS) between 1999 and 2013.
J Colloid Interface Sci
May 2016
Empa, Laboratory for High Performance Ceramics, Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, Duebendorf, Switzerland. Electronic address:
A strategy for a simple dispersion of commercial multi-walled carbon nanotubes (MWCNTs) using two organosilicones, polycarbosilane SMP10 and polysilazane Ceraset PSZ20, in organic solvents such as cyclohexane, tetrahydrofuran (THF), m-xylene and chloroform is presented. In just a few minutes the combined action of sonication and the presence of Pt(0) catalyst is sufficient to obtain a homogeneous suspension, thanks to the rapid hydrosilylation reaction between SiH groups of the polymer and the CNT sidewall. The as-produced suspensions have a particle size distribution <1μm and remain unchanged after several months.
View Article and Find Full Text PDFJ Natl Cancer Inst
May 2016
Department of Mathematics (MDR, RD) and Duke Global Health Institute (ELT), Duke University, Durham, NC; Division of Advanced Oncologic and GI Surgery (MDR, MW, ESH) and Division of Surgical Sciences (JRM), Department of Surgery, Duke University Medical Center, Durham, NC; Department of Visceral Surgery and Medicine, Inselspital, Berne University Hospital and University of Berne, Berne, Switzerland (MW); Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC (ELT).
Background: Ductal carcinoma in situ (DCIS) is a noninvasive breast lesion with uncertain risk for invasive progression. Usual care (UC) for DCIS consists of treatment upon diagnosis, thus potentially overtreating patients with low propensity for progression. One strategy to reduce overtreatment is active surveillance (AS), whereby DCIS is treated only upon detection of invasive disease.
View Article and Find Full Text PDFJ Natl Cancer Inst
December 2015
Division of Advanced Oncologic and GI Surgery, Department of Surgery, (MW, RG, DS, ESH), Center for Population Health and Aging (IA), Department of Obstetrics and Gynecology (ERM), and Department of Mathematics (MDR), Duke University Medical Center, Durham NC; Department of Visceral Surgery and Medicine, Inselspital, Berne University Hospital and University of Berne, Berne, Switzerland (MW).
Background: Impact of contemporary treatment of pre-invasive breast cancer (ductal carcinoma in situ [DCIS]) on long-term outcomes remains poorly defined. We aimed to evaluate national treatment trends for DCIS and to determine their impact on disease-specific (DSS) and overall survival (OS).
Methods: The Surveillance, Epidemiology, and End Results (SEER) registry was queried for patients diagnosed with DCIS from 1991 to 2010.
J Antimicrob Chemother
December 2015
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland Institute of Medical Virology, University of Zurich, Zurich, Switzerland
Background: The most recommended NRTI combinations as first-line antiretroviral treatment for HIV-1 infection in resource-rich settings are tenofovir/emtricitabine, abacavir/lamivudine, tenofovir/lamivudine and zidovudine/lamivudine. Efficacy studies of these combinations also considering pill numbers, dosing frequencies and ethnicities are rare.
Methods: We included patients starting first-line combination ART (cART) with or switching from first-line cART without treatment failure to tenofovir/emtricitabine, abacavir/lamivudine, tenofovir/lamivudine and zidovudine/lamivudine plus efavirenz or nevirapine.
Interact Cardiovasc Thorac Surg
September 2015
Clinic for Cardiovascular Surgery, Inselspital, Berne University Hospital and University of Berne, Berne, Switzerland.
Objectives: Oxygenation of blood and other physiological solutions are routinely required in fundamental research for both in vitro and in vivo experimentation. However, very few oxygenators with suitable priming volumes (<2-3 ml) are available for surgery in small animals. We have designed a new, miniaturized membrane oxygenator and investigated the oxygen-transfer performance using both buffer and blood perfusates.
View Article and Find Full Text PDFSpinal Cord
September 2015
Department of Osteoporosis, Inselspital, Berne University Hospital and University of Berne, Berne, Switzerland.
Study Design: Retrospective data analysis.
Objectives: To document fracture characteristics, management and related complications in individuals with traumatic spinal cord injury (SCI).
Setting: Rehabilitation centre for SCI individuals.
J Biomed Mater Res A
November 2015
Microsystems Laboratory, Ecole Polytechnique Fédérale De Lausanne (EPFL), Lausanne, CH-1015, Switzerland.
Ceramics are known to be chemically stable, and the possibility to electrically dope polymer-derived ceramics makes it a material of interest for implantable electrode applications. We investigated cytotoxic characteristics of four polymer-derived ceramic candidates with either electrically conductive or insulating properties. Cytotoxicity was assessed by culturing C2C12 myoblast cells under two conditions: by exposing them to material extracts and by putting them directly in contact with material samples.
View Article and Find Full Text PDFEur J Cardiothorac Surg
January 2016
Department of Cardiovascular Surgery, Inselspital, Berne University Hospital and University of Berne, Berne, Switzerland.
Objectives: The number of heart transplantations is limited by donor organ availability. Donation after circulatory determination of death (DCDD) could significantly improve graft availability; however, organs undergo warm ischaemia followed by reperfusion, leading to tissue damage. Laboratory studies suggest that mechanical postconditioning [(MPC); brief, intermittent periods of ischaemia at the onset of reperfusion] can limit reperfusion injury; however, clinical translation has been disappointing.
View Article and Find Full Text PDFJ Infect Dis
July 2015
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich.
Background: Transmitted human immunodeficiency virus type 1 (HIV) drug resistance (TDR) mutations are transmitted from nonresponding patients (defined as patients with no initial response to treatment and those with an initial response for whom treatment later failed) or from patients who are naive to treatment. Although the prevalence of drug resistance in patients who are not responding to treatment has declined in developed countries, the prevalence of TDR mutations has not. Mechanisms causing this paradox are poorly explored.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
November 2014
Empa, Swiss Federal Institutes for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland. Electronic address:
Recent findings in the field of biomaterials and tissue engineering provide evidence that surface immobilised growth factors display enhanced stability and induce prolonged function. Cell response can be regulated by material properties and at the site of interest. To this end, we developed scaffolds with covalently bound vascular endothelial growth factor (VEGF) and evaluated their mitogenic effect on endothelial cells in vitro.
View Article and Find Full Text PDFWorld J Gastroenterol
October 2014
Vanessa M Banz, Matthias Baechtold, Daniel Inderbitzin, Daniel Candinas, Department of Visceral Surgery and Medicine, Inselspital, Berne University Hospital and University of Berne, CH-3010 Berne, Switzerland.
For patients with extensive bilobar colorectal liver metastases (CRLM), initial surgery may not be feasible and a multimodal approach including microwave ablation (MWA) provides the only chance for prolonged survival. Intraoperative navigation systems may improve the accuracy of ablation and surgical resection of so-called "vanishing lesions", ultimately improving patient outcome. Clinical application of intraoperative navigated liver surgery is illustrated in a patient undergoing combined resection/MWA for multiple, synchronous, bilobar CRLM.
View Article and Find Full Text PDFOsteoporos Int
July 2014
Department of Osteoporosis, Inselspital, Berne University Hospital and University of Berne, CH-3010, Berne, Switzerland.
Unlabelled: Treatment effects over 2 years of teriparatide vs. ibandronate in postmenopausal women with osteoporosis were compared using lumbar spine bone mineral density (BMD) and trabecular bone score (TBS). Teriparatide induced larger increases in BMD and TBS compared to ibandronate, suggesting a more pronounced effect on bone microarchitecture of the bone anabolic drug.
View Article and Find Full Text PDFNat Rev Cardiol
June 2014
Department of Cardiovascular Surgery, Inselspital, Berne University Hospital and University of Berne, Murtenstrasse 35, CH-0310, Switzerland.
The constant shortage of available organs is a major obstacle and limiting factor in heart transplantation; the discrepancy between the number of donors and potential recipients leads to waiting-list mortality of 10-12% per year in Europe and the USA. If adopted for heart transplantation, donation after circulatory determination of death (DCDD) would be expected to improve the availability of organs substantially for both adults and children. With DCDD, however, hearts to be transplanted undergo a period of warm ischaemia before procurement, which is of particular concern because tissue damage occurs rapidly and might be sufficient to preclude transplantation.
View Article and Find Full Text PDFBackground: Areal bone mineral density is predictive for fracture risk. Microstructural bone parameters evaluated at the appendicular skeleton by high-resolution peripheral quantitative computed tomography (HR-pQCT) display differences between healthy patients and fracture patients. With the simple geometry of the cortex at the distal tibial diaphysis, a cortical index of the tibia combining material and mechanical properties correlated highly with bone strength ex vivo.
View Article and Find Full Text PDF