4 results match your criteria: "Berlin Institute of Health at Charité -Universitätsmedizin[Affiliation]"
Age-Related Differences in Structure and Function of Nasal Epithelial Cultures From Healthy Children and Elderly People.
Front Immunol
May 2022
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Chariteí - Universitaätsmedizin Berlin, Berlin, Germany.
The nasal epithelium represents the first line of defense against inhaled pathogens, allergens, and irritants and plays a key role in the pathogenesis of a spectrum of acute and chronic airways diseases. Despite age-dependent clinical phenotypes triggered by these noxious stimuli, little is known about how aging affects the structure and function of the airway epithelium that is crucial for lung homeostasis and host defense. The aim of this study was therefore to determine age-related differences in structural and functional properties of primary nasal epithelial cultures from healthy children and non-smoking elderly people.
View Article and Find Full Text PDFCharacterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.
Hypertension
August 2019
From the Charité-Universitätsmedizin Berlin, corporate member of Freie Universitaät Berlin, Humboldt-Universitaät zu Berlin, and Berlin Institute of Health, Institute of Pharmacology, Center for Cardiovascular Research, Berlin, Germany (N.B., A.F.-L., S.B., J.G., Arne Thiele, U.K.).
Article Synopsis
- - The study investigates how subendocardial damage due to hypertension impacts the structure and function of the heart, highlighting early signs of cardiac problems even in asymptomatic individuals.
- - Mice induced with subendocardial scarring showed diastolic dysfunction, changes in myocardial deformation, and increased expression of specific biomarkers, while systolic function remained normal.
- - Advanced imaging techniques indicated that alterations in myocardial microstructure, particularly in subepicardial myofibers, can serve as early indicators for subendocardial fibrosis, with high sensitivity and specificity for predicting cardiac damage.
Dietary patterns and respiratory health in adults from nine European countries-Evidence from the GA LEN study.
Clin Exp Allergy
November 2018
Population Health and Occupational Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Article Synopsis
- A study analyzed dietary patterns across nine European countries to see how they relate to asthma and allergic symptoms, using a food frequency questionnaire and respiratory symptom assessments from over 3,200 participants aged 15-77.
- Two main dietary patterns were identified: one high in animal proteins and carbohydrates, and the other rich in fruits and vegetables.
- The results indicated that the diet high in animal proteins and carbohydrates was linked to worse asthma outcomes, including higher asthma scores, greater prevalence of current asthma, wheezing, atopic status, and reduced lung function.
Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?
Am J Transplant
December 2016
Medical Research Council Centre for Transplantation, King's College London, London, United Kingdom.
We and others have previously described signatures of tolerance in kidney transplantation showing the differential expression of B cell-related genes and the relative expansions of B cell subsets. However, in all of these studies, the index group-namely, the tolerant recipients-were not receiving immunosuppression (IS) treatment, unlike the rest of the comparator groups. We aimed to assess the confounding effect of these regimens and develop a novel IS-independent signature of tolerance.
View Article and Find Full Text PDF