Multi-input Drug-Controlled Switches of Mammalian Gene Expression Based on Engineered Nuclear Hormone Receptors.

Protein-based switches that respond to different inputs to regulate cellular outputs, such as gene expression, are central to synthetic biology. For increased controllability, multi-input switches that integrate several cooperating and competing signals for the regulation of a shared output are of particular interest. The nuclear hormone receptor (NHR) superfamily offers promising starting points for engineering multi-input-controlled responses to clinically approved drugs.

The One-to-One Constraint in Analogical Mapping and Inference.

Theories of analogical reasoning have assumed that a 1-to-1 constraint discourages reasoners from mapping a single element in 1 analog to multiple elements in another. Empirical evidence suggests that reasoners sometimes appear to violate the one-to-one constraint when asked to generate mappings, yet virtually never violate it when asked to generate analogical inferences. However, few studies have examined analogical inferences based on nonisomorphic analogs, and their conclusions are suspect due to methodological problems.