1,196 results match your criteria: "Benign Childhood Epilepsy"
Clin Neurol Neurosurg
December 2024
Pediatric Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena 41121, Italy. Electronic address:
Typical absence seizures represent a distinctive form of epileptic activity typically observed in pediatric populations, predominantly manifesting between the ages of 4 and 10, constituting Childhood Absence Epilepsy (CAE). However, a subset of patients presents with Early-onset Absence Epilepsy (EOAE), characterized by seizure onset before the fourth year of life, often displaying favorable outcomes with antiseizure medication. Conversely, atypical absence seizures exhibit prolonged duration and frequently entail tonic, atonic, or myoclonic motor elements, suggesting a more severe clinical course, commonly associated with epileptic encephalopathies of childhood onset.
View Article and Find Full Text PDFIndian J Pediatr
January 2025
Epilepsy Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada.
J Clin Neurosci
November 2024
Department of Radiology, Shenzhen Children's Hospital, Shenzhen 518038, China. Electronic address:
Objective: This study aims to explore differences in the static and dynamic amplitude of low-frequency fluctuations (sALFF and dALFF) in resting-state functional MRI (rs-fMRI) data between patients with Benign childhood epilepsy with centrotemporal spikes (SeLECTS) and healthy controls (HCs).
Materials And Methods: We recruited 45 patient with SeLECTS and 55 HCs, employing rs-fMRI to assess brain activity. The analysis utilized a two-sample t-test for primary comparisons, supplemented by stratification and matching based on clinical and demographic characteristics to ensure comparability between groups.
Front Med (Lausanne)
July 2024
One Health Research Group, Universidad de las Américas, Quito, Ecuador.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Department of Radiology, Shenzhen Children's Hospital, Shenzhen 518038, China. Electronic address:
Front Neurol
July 2024
Department of Otolaryngology and Head and Neck Surgery, Division of Otology and Neurotology, University of Virginia, Charlottesville, VA, United States.
Eur Radiol
January 2025
Department of Radiology, The Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Objectives: To explore the interrelationships between structural and functional changes as well as the potential neurotransmitter profile alterations in drug-naïve benign childhood epilepsy with central-temporal spikes (BECTS) patients.
Methods: Structural magnetic resonance imaging (sMRI) and resting-state functional MRI data from 20 drug-naïve BECTS patients and 33 healthy controls (HCs) were acquired. Parallel independent component analysis (P-ICA) was used to identify covarying components among gray matter volume (GMV) maps and fractional amplitude of low-frequency fluctuations (fALFF) maps.
Radiol Case Rep
September 2024
Neuroradiology department- Ibn Sina University hospital, Rabat, Morocco.
Neuroimage Clin
September 2024
Department of Radiology, the Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi 563000, China. Electronic address:
Seizure
July 2024
Department of Neuroscience, Imaging and Clinical Science, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy; Neurology Clinic, Epilepsy Center, "SS Annunziata" Hospital of Chieti, Chieti, Italy; Behavioral Neurology and Molecular Neurology Units, Center for Advanced Studies and Technology - CAST-, University G. d'Annunzio of Chieti-Pescara, Italy.
Background: The proline-rich transmembrane protein 2 (PRRT2) is a synaptic protein involved in neurotransmitter vesicle release. PRRT2 protein is highly expressed in the cerebellum, cerebral cortex, basal ganglia, and hippocampus. Variants in PRRT2 have been identified as a cause of several neurological disorders, including epilepsy, movement disorders, and headache.
View Article and Find Full Text PDFEur J Med Genet
June 2024
Department of Neurology, The Affiliated Children's Hospital Of Xiangya School of Medicine, Central South University(Hunan children's hospital), Changsha, Hunan, China. Electronic address:
Germline MICAL1 defects have been rarely reported in patients with epilepsy and the genotype-phenotype association remains unclear. In this study, the patient was a 4.6 years old girl who presented with onset of recurrent focal seizures with onset at age 3.
View Article and Find Full Text PDFPak J Med Sci
January 2024
Na Kong, Department of Pediatrics, Xingtai People's Hospital, Xingtai 054000, Hebei, P.R. China.
Objective: To explore risk factors of electrical status epilepticus during sleep in children with benign childhood epilepsy with centro-temporal spikes (BECT).
Methods: This is a clinical comparative study. The subjects of study were 67 children with BECT from the Outpatient Department of Pediatric Neurology in Xingtai People's Hospital from January 2019 to January 2022.
Pediatr Res
July 2024
Department of Radiology, The Seventh People's Hospital of Chongqing, The Central Hospital Affiliated to Chongqing University of Technology, Chongqing, China.
Background: Benign epilepsy with centrotemporal spikes (BECTS) is a common childhood epilepsy syndrome, accompanied by behavioral problems and cognitive impairments. Previous studies of BECTS-related brain structures applied univariate analysis and showed inconsistent results. And neurotransmitter patterns associated with brain structural alterations were still unclear.
View Article and Find Full Text PDFJ Biomol Struct Dyn
February 2024
School of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan.
With over 2.2 million cases, the incidence rate of epilepsy in Pakistan is far higher than the rest of the world due primarily to the frequent, traditionally imposed cousin marriages. In the present study, comprehensive whole exome sequencing (WES) analyses of a three-generation family with four affected members presenting 'unexplained' childhood absence epilepsy (CAE), seizures and dementia, was performed in a quest to identify heritable, epilepsy-causal gene variants to better aid in carrier screening and genetic counselling.
View Article and Find Full Text PDFEpilepsy Behav
March 2024
University Children's Hospital, Ruhr University Bochum, Department of Neuropediatrics Bochum, Germany.
Purpose: Our aim was to assess intelligence, visual perception and working memory in children with new-onset Rolandic epilepsy (RE) and children with Rolandic discharges without seizures (RD).
Methods: The participants in the study were 12 children with RE and 26 children with RD aged 4 to 10 years (all without medication and shortly after diagnosis) and 31 healthy controls. Their cognitive performance was assessed using the German versions of the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III), the Wechsler Intelligence Scale for Children (WISC-IV), the Developmental Test of Visual Perception-2 (DTVP-2), the Developmental Test of Visual Perception-Adolescent and Adult (DTVP-A) (each according to age) and the Word Order, Hand Movements and Spatial Memory subtests of the German version of the Kaufman Assessment Battery for Children (K-ABC).
Int J Mol Sci
January 2024
Child Neurology and Psychiatry Unit, Department of Pediatrics, Presidio Ospedaliero Santa Maria Nuova, AUSL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
The genetic causes of epilepsies and developmental and epileptic encephalopathies (DEE) with onset in early childhood are increasingly recognized. Their outcomes vary from benign to severe disability. In this paper, we wished to retrospectively review the clinical, genetic, EEG, neuroimaging, and outcome data of patients experiencing the onset of epilepsy in the first three years of life, diagnosed and followed up in four Italian epilepsy centres (Epilepsy Centre of San Paolo University Hospital in Milan, Child Neurology and Psychiatry Unit of AUSL-IRCCS di Reggio Emilia, Pediatric Neurology Unit of Vittore Buzzi Children's Hospital, Milan, and Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia).
View Article and Find Full Text PDFCephalalgia
January 2024
Developmental Neurology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy.
Background: Primary stabbing headache (PSH) is an idiopathic headache disorder characterized by head pain occurring as a transient and localized single stab or a series of stabs. The present study aimed to examine the characteristics of childhood PSH and whether they fit the International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria. We also investigated the association with migraine and episodic syndromes.
View Article and Find Full Text PDFFront Neurol
December 2023
Neurology Department, Hunan Children's Hospital, Changsha, China.
Objective: This study aimed to examine the clinical and gene-mutation characteristics of pediatric patients with sodium channel gene mutation-related childhood epilepsy and to provide a basis for precision treatment and genetic counseling.
Methods: The clinical data from 94 patients with sodium channel gene mutation-related childhood epilepsy who were treated at Hunan Children's Hospital from August 2012 to December 2022 were retrospectively evaluated, and the clinical characteristics, gene variants, treatment, and follow-up status were analyzed and summarized.
Results: Our 94 pediatric patients with sodium channel gene variant-related childhood epilepsy comprised 37 girls and 57 boys.
In Vivo
December 2023
Division of Child Neurology, Department of Pediatrics, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Background/aim: Kelch-like protein 11 (KLHL11)-antibody may be found in paraneoplastic neurological disorders presenting with epileptic seizures. The aim of this study was to investigate the prevalence and clinical significance of KLHL11-antibody in epilepsy.
Patients And Methods: Sera of 42 pediatric and 59 adult patients with seizures of undetermined cause were screened using a cell-based assay.
Biomedicines
December 2023
Neuroscience and Rare Diseases, Discovery and Translational Area, Roche Pharma Research and Early Development (pRED), F. Hoffmann-La Roche, 4070 Basel, Switzerland.
Tuberous sclerosis complex (TSC) is a rare multisystem genetic disorder characterized by benign tumor growth in multiple organs, including the brain, kidneys, heart, eyes, lungs, and skin. Pathogenesis stems from mutations in either the TSC1 or TSC2 gene, which encode the proteins hamartin and tuberin, respectively. These proteins form a complex that inhibits the mTOR pathway, a critical regulator of cell growth and proliferation.
View Article and Find Full Text PDFEpilepsy Res
January 2024
Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Victoria, Australia; Department of Neurology, The Royal Children's Hospital, Melbourne, Victoria, Australia.
Purpose: To study seizure manifestations and outcomes in children with cortical versus white matter injury, differences potentially explaining variability of epilepsy in children with cerebral palsy.
Methods: In this population-based retrospective cohort study, MRIs of children with cerebral palsy due to ischemia or haemorrhage were classified according to presence or absence of cortical injury. MRI findings were then correlated with history of neonatal seizures, seizures during childhood, epilepsy syndromes, and seizure outcomes.
Heliyon
December 2023
Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.
Clin Neurol Neurosurg
November 2023
Regional Epilepsy Center, Operative Unit of Childhood and Adolescent Neuropsychiatry - ASST Spedali Civili di Brescia, Brescia, Italy.