Correction: Saber et al. BD-AcAc2 Mitigates Chronic Colitis in Rats: A Promising Multi-Pronged Approach Modulating Inflammasome Activity, Autophagy, and Pyroptosis. 2023, , 953.

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Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies.

: Mirtazapine (MRZ) is a psychotropic drug prescribed to manage serious sorts of depression. By virtue of its extensive initial-pass metabolic process with poor water solubility, the ultimate bioavailability when taken orally is a mere 50%, necessitating repeated administration. The current inquiry intended to fabricate nose-to-brain chitosan-grafted cationic leciplexes of MRZ (CS-MRZ-LPX) to improve its pharmacokinetic weaknesses and boost the pharmacodynamics aspects.

Therapeutic Efficacy of 's Oil and Ethanol Extract in Regulation of the Neuroinflammation, Histopathological Alterations, Oxidative Stress, and Restoring Balance Treg Cells Expressing FoxP3+ in a Rat Model of Epilepsy.

: Despite the availability of antiepileptic drugs (AEDs) that can manage seizures, they often come with cognitive side effects. Furthermore, the role of oxidative stress and neuroinflammatory responses in epilepsy and the limitations of current AEDs necessitate exploring alternative therapeutic options. Medicinal plants, e.

Fabrication and In Vivo Evaluation of In Situ pH-Sensitive Hydrogel of Sonidegib-Invasomes via Intratumoral Delivery for Basal Cell Skin Cancer Management.

Background/objectives: Basal cell skin cancer (BCSC) develops when skin cells proliferate uncontrollably. Sonidegib (SDB) is a therapeutic option for the treatment of BCSC by inhibiting hedgehog signaling. The problems with SDB's low solubility, poor bioavailability, resistance, poor targeting, and first-pass action make it less effective when taken orally.

Animal Brucellosis in Egypt: Review on Evolution, Epidemiological Situation, Prevalent Strains, Genetic Diversity, and Assessment of Implemented National Control Measures.

Brucellosis is a neglected zoonotic disease that has a significant economic and public health impact, especially in endemic countries. This review delves deeply into brucellosis's current epidemiological situation and potential sources of livestock infection in Egypt during the last two decades. MLVA-16 and Whole Genome Sequencing based on core-genome SNP analyses confirm the presence of different and outbreak strains, both older widely disseminated strains and newly introduced ones.

Dermanyssus gallinae as a pathogen vector: Phylogenetic analysis and associated health risks in pigeons.

Dermanyssus gallinae (D. gallinae) is a nocturnal, blood-feeding ectoparasite that primarily infests poultry, causing significant economic losses. This study aimed to identify poultry red mites and detect associated pathogens using morphological and molecular techniques.

Granisetron ameliorates doxorubicin-evoked nephrotoxicity via modulation of Nrf2 and TLR4/p38 MAPK/NLRP3 signals in rats.

Doxorubicin (DOX) is an anthracycline chemotherapy employed in treating malignancies. Unfortunately, the clinical application of DOX is limited due to its nephrotoxicity. Granisetron (GRAN) is a 5-HT3 receptor blocker used widely to manage post-chemotherapy nausea and vomiting with anti-inflammatory, anti-oxidant, and anti-apoptotic bioactivities.

Optimized peptide inhibitor Aqs1C targets LasR to disrupt quorum sensing and biofilm formation in Pseudomonas aeruginosa: Insights from MD simulations and in vitro studies.

Pseudomonas aeruginosa (PA) is a critical pathogen, and its antibiotic resistance is largely driven by the quorum-sensing regulator LasR. Herein, we report the design, synthesis, and characterization of Aqs1C, a mutated peptide derivative of Aqs1, optimized to inhibit LasR and its quorum-sensing pathway. By introducing a targeted mutation, Aqs1C exhibited enhanced stability and binding affinity for LasR protein compared to its predecessor, Aqs1B.

Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023).

Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023. With a focus on recent research findings, the review explores the rich biodiversity of marine organisms, including sponges, corals, algae, and microorganisms, which have yielded numerous compounds exhibiting promising anticancer properties.

Long-term clinical outcomes of isolated orbital floor fracture reconstruction using nonresorbable implants.

Purpose: There are no universally established guidelines for material selection in orbital wall fracture reconstruction. With an increasing preference for permanent implants, this study aimed to compare the long-term clinical outcomes of three different non-resorbable materials in reconstructing isolated orbital floor fractures.

Design: A retrospective, interventional comparative study.

Correction: AlTawari et al. Nusinersen Treatment for Spinal Muscular Atrophy: Retrospective Multicenter Study of Pediatric and Adult Patients in Kuwait. 2024, , 631-642.

In the published publication [...

Anti-arthritic Effects of Undifferentiated and Chondrogenic Differentiated MSCs in MIA-induced Osteoarthritis in Wistar Rats: Involvement of Oxidative Stress and Immune Modulation.

Introduction: Osteoarthritis (OA) is a degenerative joint disease that can affect the many tissues of the joint. There are no officially recognized disease-modifying therapies for clinical use at this time probably due to a lack of complete comprehension of the pathogenesis of the disease. In recent years, emerging regenerative therapy and treatments with stem cells both undifferentiated and differentiated cells have gained much attention as they can efficiently promote tissue repair and regeneration.

Correlation between seminal α-glycerylphosphorylcholine and semen parameters in infertile patients pre- and post-sub-inguinal micro-varicocelectomy: a prospective study.

Background: Varicocele (Vx) which is the most treatable cause of male infertility, is also associated with low sperm count, decreased sperm motility and increased sperm abnormal morphology. We aimed in the current study to evaluate the correlation between seminal α-Glycerylphosphorylcholine (αGPC) and semen parameters in infertile patients pre- and post- sub-inguinal micro-varicocelectomy.

Methods: The current comparative prospective study was carried out on 20 male patients who presented to Kasr Al-Ainy Hospitals from March 2022 to March 2023 as well as 20 healthy controls.

Boosting the mechanical performance and fire resistivity of white ordinary portland cement pastes via biogenic mesoporous silica nanoparticles.

This study investigates how biogenic mesoporous silica nanoparticles (MS-NPs) extracted from rice straw residues, a sustainable and economical bio-source, affect White Ordinary Portland Cement (WOPC) paste performance. A comprehensive investigation using varied fractions of 0.25, 0.

A thin film optoelectronic photodetector of spherical and linear resonators via one-pot synthesis of Bi(III) oxide/polypyrrole nanocomposite.

We report the fabrication and characterization of a Bi(III) oxide/polypyrrole (BiO/Ppy) nanocomposite thin film optoelectronic photodetector synthesized by a simple one-pot method. The nanocomposite consists of spherical BiO nanoparticles embedded in a Ppy matrix, forming a porous structure with a high surface area. The XRD analysis reveals that the BiO nanoparticles have a poly-crystalline nature with a crystal size of 40 nm and an optical bandgap of 2.

Evaluating Machine Learning and Deep Learning models for predicting Wind Turbine power output from environmental factors.

This study presents a comprehensive comparative analysis of Machine Learning (ML) and Deep Learning (DL) models for predicting Wind Turbine (WT) power output based on environmental variables such as temperature, humidity, wind speed, and wind direction. Along with Artificial Neural Network (ANN), Long Short-Term Memory (LSTM), Recurrent Neural Network (RNN), and Convolutional Neural Network (CNN), the following ML models were looked at: Linear Regression (LR), Support Vector Regressor (SVR), Random Forest (RF), Extra Trees (ET), Adaptive Boosting (AdaBoost), Categorical Boosting (CatBoost), Extreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine (LightGBM). Using a dataset of 40,000 observations, the models were assessed based on R-squared, Mean Absolute Error (MAE), and Root Mean Square Error (RMSE).

The impact of virtual reality on maternal anxiety, satisfaction, and fetal outcomes among pregnant women undergoing non-stress tests: A systematic review and meta-analysis of randomized controlled trials.

We aimed to investigate the impact of virtual reality (VR) on maternal anxiety, satisfaction, and fetal physiological parameters during non-stress test (NST) in pregnant women. We conducted an extensive search across numerous databases to identify eligible studies from inception to April 2024. Researchers included randomized trials that compared VR intervention during NSTs in the third trimester with control groups.

A biocompatible β-cyclodextrin inclusion complex containing natural extracts: a promising antibiofilm agent.

Biofilms formed by several bacterial strains still pose a significant challenge to healthcare due to their resistance to conventional treatment approaches, including antibiotics. This study explores the potential of loading natural extracts with antimicrobial activities into β-cyclodextrin (βCD) nanoparticles, which are FDA-approved and have superior biocompatibility owing to their cyclic sugar structures, for biofilm eradication. An inclusion complex of βCD carrying essential oils (BOS) was prepared and characterized with regard to its physicochemical properties, antimicrobial efficacy, and antibiofilm activities.

Modeling of lifetime scenarios with non-monotonic failure rates.

The Weibull distribution is an important continuous distribution that is cardinal in reliability analysis and lifetime modeling. On the other hand, it has several limitations for practical applications, such as modeling lifetime scenarios with non-monotonic failure rates. However, accurate modeling of non-monotonic failure rates is essential for achieving more accurate predictions, better risk management, and informed decision-making in various domains where reliability and longevity are critical factors.

One pot synthesis of poly m-toluidine incorporated silver and silver oxide nanocomposite as a promising electrode for supercapacitor devices.

The design and fabrication of novel electrodes with strong electrochemical responses are crucial in advanced supercapacitor technology. In this study, a poly(m-toluidine)/silver-silver oxide (PMT/Ag-AgO) nanocomposite was prepared using the photopolymerization method. Various characterization techniques were employed to analyze the prepared nanomaterials.

In-vivo implementation of the HPTLC methodology to rat plasma for the concurrent determination of a novel combination therapy for the management of COVID-19 (favipiravir and nitazoxanide).

The 2019 coronavirus outbreak has prompted scientists to investigate pharmaceuticals to prevent the spread of the disease. Favipiravir (FAV) has received Food and Drug Administration FDA approval for the treatment of various viral infections with notable efficacy in clinical trials for COVID-19. Nitazoxanide (NTZ) is a broad-spectrum antiparasitic and antiviral agent used for the treatment of parasitic illnesses.

Genetic diversity and antigenic variability of foot-and-mouth disease virus strains in Egypt.

Foot-and-mouth disease (FMD) continues to pose a significant threat in Egypt, necessitating thorough analyses of FMD virus (FMDV) outbreaks. This study analyzed 144 suspected FMD cases across 52 animal collections during the years 2017-2018 and 2022. Recurrent FMD outbreaks in vaccinated dairy cattle were investigated.

Analysis of the defect mode features in an asymmetric and symmetric acoustic system using expansion chambers.

In this paper, the transfer matrix method is used to study the dispersion of acoustic waves in a finite periodic expansion chambers system with a defect. Two kinds of structures are studied. The first one is formed by expansion chambers, which are symmetrical concerning a defect, and the second one is asymmetrical with a defect.

Pyrimidine scaffold dual-target kinase inhibitors for cancer diseases: A review on design strategies, synthetic approaches, and structure-activity relationship (2018‒2023).

Cancer, the second leading cause of death globally, causes a significant threat to life. Despite advancements in the treatment of cancer, persistent challenges include severe side effects and the emergence of acquired drug resistance. Additionally, many traditional chemotherapy drugs show restricted efficacy and high toxicity, primarily attributed to their lack of selectivity.

Trajectory of Cardiogenic Dementia: A New Perspective.

The functions of the heart and brain are closely linked and essential to support human life by the heart-brain axis, which is a complex interconnection between the heart and brain. Also, cardiac function and cerebral blood flow regulate the brain's metabolism and function. Therefore, deterioration of cardiac function may affect cognitive function and may increase the risk of dementia.